Abstract：
INTRODUCTION:Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described. CASE REPORT:We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus. The dermatosis responded well to corticosteroids. The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy. DISCUSSION:This case report updates this rare association and underlines the importance of undertaking appropriate thoracic investigations in the presence of this dermatosis. A paraneoplastic secretion of interleukin-8, GM-CSF and/or G-CSF by the bronchial tumour cells facilitating the recruitment of neutrophils, particularly in the skin, may account for the pathophysiology of this condition.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Van Denhove A,Freymond N,Isaac S,Marrou K,Balme B,Gormand F,Guibert B,Pacheco Y,Devouassoux Gsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
77-80issue
1eissn
0761-8425issn
1776-2588pii
MDOI-RMR-01-2007-24-1-0761-8425-101019-200520011journal_volume
24pub_type
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