Abstract：
INTRODUCTION:The epidemiology of chronic beryllium disease (CBD) in France is poorly understood. The aim of this study was to determine the number of prevalent cases of CBD in France between 2010 and 2014. METHODS:We conducted a national survey using a specific questionnaire distributed by the professional pathology services. RESULTS:In total, 33 CBD cases were reported in France, with a diagnosis established between 1982 and 2014. 85% (28/33) of CBD cases resulted from professional exposure and mostly concerned foundry workers (39%). A definite diagnosis defined by the association of an abnormal beryllium lymphocyte proliferation test and of a granulomatous inflammatory response in the lung, was obtained in 29/33 cases (88%). The other cases were probable CBD, defined by a granulomatous lung disease with a beryllium exposure, but without evidence of beryllium sensitisation. The diagnosis of granulomatous disease was confirmed a mean of 4 years after the end of exposure. The median delay between diagnosis of a granulomatous disease and diagnosis of CBD was 2 years (range 0-38 years). A genetic predisposition was found in 14 of 17 tested patients (82%). CONCLUSION:In this study, we report 33 cases of CBD followed in France between 2010 and 2014. The poor understanding of CBD and the exposure leading to it, the late development after the end of exposure, the complexity of the diagnosis and the similarities with sarcoidosis may explain the small number of cases reported.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Ghanem M,Naccache JM,Bonneterre V,L'huillier JP,Guillaud Segard B,Lazor R,Tazi A,Gondouin A,Israël-Biet D,Marquignon MF,Cottin V,Valeyre D,Marchand-Adam Sdoi
10.1016/j.rmr.2020.03.003subject
Has Abstractpub_date
2020-05-01 00:00:00pages
364-368issue
5eissn
0761-8425issn
1776-2588pii
S0761-8425(20)30100-5journal_volume
37pub_type
杂志文章abstract：INTRODUCTION:Sleep disturbances may make smoking cessation more difficult and relapses more frequent. STATE OF THE ART:Nicotine increases vigilance and decreases sleeping time. Cigarette smoking is associated both with difficulty initiating and maintaining sleep. The disruption is associated with arousals on EEG recor...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：:Thrombocytopenia induced by rifampicin in the absence of prior sensitization is exceptional, especially when it occurs in a patient without risk factors. We report the case of a patient aged 25 years with no past history of medical, surgical or knowledge of having taken rifampicin previously, who was hospitalized for ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.03.009
更新日期：2013-11-01 00:00:00
abstract：:Recent progress in the physiology of the upper airways has led to significant advances in evaluating the dynamics of upper airway occlusion during sleep. Measuring the collapsibility of the upper airways and localizing the site of obstruction should theoretically lead to efficacious non-mechanical treatment and enable...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：INTRODUCTION:The histology and staging of bronchial carcinoma determines the treatment options for the condition. Endobronchial ultrasound allows the needle aspiration of mediastinal lymph nodes or pulmonary neoplasia where there is tracheo-bronchial contact under visual control. This procedure is aid for diagnosis and...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(08)74350-x
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:Pulmonary artery sarcoma is a rare disease with non-specific symptoms. The clinical and radiological presentation can mimic pulmonary embolism with chronic thromboembolic pulmonary hypertension. Management is essentially surgical but the prognosis remains poor. CASE REPORT:A patient presented with symptom...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2015.07.001
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Smoke inhalation and respiratory complications are still the major causes of mortality in severely burned patients. STATE OF THE ART:The diagnosis is suspected clinically on the basis of history and physical examination and can be confirmed bronchoscopically. Respiratory failure in burned patients occurs ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(05)85572-x
更新日期：2005-06-01 00:00:00
abstract：:Results of isolated surgical resection for stage III lung cancer are not satisfactory, since overall 5-year survival rates rarely exceed 15%. Deaths during follow-up are mainly due to metastatic progression. The multimodality approach adds chemotherapy to surgery, with the intent to improve the control of micrometasta...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：INTRODUCTION:Positron emission tomography (PET) with 18F-FDG has become an important tool for the characterization of solitary pulmonary nodules (SPN). BACKGROUND:The results of the main meta-analyses show that the sensitivity and specificity of 18F-FDG PET for determining malignancy of SPN are close to 95% and 80% re...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(09)73531-4
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:We report a case of extensive pulmonary nocardiosis in a patient infected with HIV. CASE REPORT:It presented as bilateral cavitated masses and bulky necrotic mediastinal lymphadenopathy causing broncho-oesophageal fistulae. There was associated infection with Mycobacterium Avium. There was satisfactory pr...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(04)71247-4
更新日期：2004-02-01 00:00:00
abstract：:Bromocriptine, a derivative of ergot of rye, is used in high doses for the treatment of Parkinson's disease and may be responsible for pleuro-pulmonary complications. We report a case of a 72 year old patient treated for 2 years for Parkinson's disease with a daily dose of 30 mgms. of bromocriptine and in whom a pleur...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Bronchial provocation tests are useful for the detection of subclinical bronchial hyper-reactivity. Their standardisation is vital, in particular the method of administration of the bronchoconstrictor agent. Our study compares two systems of histamine delivery: an aerosol propellant with freons and a jet nebuliser lin...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The occurrence of pulmonary fibrosis in numerous individuals from the same family suggests a genetic cause for the disease. During the last 10 years, mutations involving proteins from the telomerase complex and from the surfactant system have been identified in association with pulmonary fibrosis. Mutations of TERT, t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2014.07.017
更新日期：2015-04-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between asthma, the respiratory history and possible disturbances of pulmonary function in teenage asthmatics. This aetiological study was carried out in 103 asthmatics and 1094 controls who were teenagers attending schools in Bordeaux. In addition to the data ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：INTRODUCTION:Exhaled carbon monoxide (ECO) concentration provides an easy, fast and non invasive means of assessing smoking status. However, some difficulties have to be considered when interpreting ECO levels. BACKGROUND:CO is a non-specific biomarker of tobacco exposure. Its half-life is short (2-6 hours). CO reflec...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2009.09.004
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Quality of life is rarely assessed in the pulmonary function laboratory. Quality of life, or at least some of its domains, should be directly measured. STATE OF ART:Quality-of-life questionnaires developed according to established protocols can be very useful in clinical practice. In clinical studies, the...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:The aim of this work was to study the kinetic of intramacrophage penetration of cotrimoxazole in guinea pigs which had received 100 mg/kg of sulfamethoxazole and 20 mg/kg of trimethoprim after a single intraperitoneal injection. 30 minutes, 1, 3, 6 and 24 hours after this injection an intra-cardiac blood sample was ta...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Amyopathic dermatomyositis associated with anti-MDA5 autoantibodies is a rare and very recently described clinical entity. CASE REPORT:A 58-year-old woman was admitted with subacute onset of dyspnea (NYHA class IV) associated with cough, oligoarthritis of the wrists, myalgia and intermittent fever. Examin...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2014.02.010
更新日期：2014-11-01 00:00:00
abstract：:The link between tuberculosis and HIV infection has long been established but the link between tuberculosis and smoking is not well understood. However, many patients with tuberculosis are smokers and an increasing proportion of them live in developing countries where there is a high incidence of the disease. Smoking ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2012.04.007
更新日期：2012-10-01 00:00:00
abstract：:The consensus conference convened by the French Language Society for Infectious Disease at Lille in 1991 stressed the fact that two germs were most often the cause of exacerbation in chronic bronchitis (Streptococcus pneumoniae and Haemophilus influenzae) and that antibiotic therapy was the "safe solution" and that th...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Autofluorescence endoscopy has been used for more than 10 years in the diagnosis of early lung cancers and precancerous lesions of the bronchial tree. The technique has been extensively evaluated during the past decade and two recent large randomised studies have shown a 2 to 5 times increase in the detection of high ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Optimal duration of first line chemotherapy for non surgical non small cell lung cancer (NSCLC) is still debated. It concerns the length of initial chemotherapy and the use of maintenance treatments. METHODS:Literature review was performed on maintenance and duration of chemotherapy. RESULTS:The use of mai...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:In western countries, community-acquired pneumonias due to Klebsiella pneumoniae (Kp) are rare and associated with a poor prognosis and a high mortality. The severity is in part linked to the virulence of Kp. Immuno-depression, sepsis and visceral abscesses are frequently found, constituting other classica...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(09)72429-5
更新日期：2009-09-01 00:00:00
abstract：:Salmeterol is an original molecule characterized by its long duration of action (greater than 12 hrs in humans). Salmeterol is a highly selective beta-2 agonist that is from 2 to 15 times more potent than salbutamol on beta-2 receptors of bronchial smooth muscle and 10,000 times more potent than isoprenaline on beta-1...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Recent multi-centre studies have shown that high doses of Almitrine (100-200 mg per day), lead to a significant improvement in the hypoxaemia of patients presenting with chronic airflow obstruction, but that a high blood level (greater than 500 ng/ml) is often seen after 1 year, sometimes associated with signs of peri...
journal_title：Revue des maladies respiratoires
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:Fertility and reproduction are now frequent questions for cystic fibrosis adult patients. Females are sometimes subfertile because of abnormal cervical mucus viscosity or anovulatory cycles. After genetic counseling and evaluation of respiratory prognosis, assisted reproduction can be proposed. Fertility is frequently...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：INTRODUCTION:This study analyzes the relationship between the occurrence of spontaneous pneumothorax and atmospheric pressure. PATIENTS AND METHODS:We conducted a retrospective study on 74 patients hospitalized for spontaneous pneumothorax in the department of respiratory diseases from the Ibn Roshd university hospita...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2018.04.008
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Thymic epithelial tumors (TET), including thymomas and thymic carcinomas, are rare and characterized by very different evolutionary patterns depending on histology and invasion stage. The therapeutic management is not well defined but is a subject of increasing interest. The descriptive and analytic objectiv...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.09.015
更新日期：2014-09-01 00:00:00
abstract：:Respiratory disease is the major cause of morbidity and mortality in cystic fibrosis. Cystic fibrosis was long treated in the pediatric setting, but improved survival has led to the implication of adult pneumology in therapeutic management. Since the gene causing cystic fibrosis has been clone, our knowledge of the pa...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：:The definition of asthma brings with it the idea of inflammation, as bronchial obstruction, which characterises it, is associated with bronchospasm, hypersecretion and oedema. In the asthmatic, awareness of the bronchial inflammation at the time of diagnosis is essential, as it contributes to prognosis and therapeutic...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:No treatment was established for disseminated M. avium intracellulare (MAC) infection, a common disease of end stage of AIDS. An open study was conducted to assess in 173 AIDS patients, the activity of clarithromycin. Initial bacteriologic eradication from blood was observed in 136/147 evaluable patients (93%). Acquir...
journal_title：Revue des maladies respiratoires
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1994-01-01 00:00:00
