Abstract：
STATE OF THE ART:The IRAD2 trial is evaluating a 3-month home intervention which includes education, oral supplements, exercise and androgenic steroids in undernourished patients with chronic respiratory failure. The main objective is to increase the six-minute walking distance by more than 50 m with an improvement in health-related quality-of-life. Secondary end-points include a reduction in exacerbation rates by 25%, a reduction in health-related costs and an increase in survival during the year following intervention. MATERIAL AND METHODS:This interventional, multi-centre, prospective, two-armed parallel, controlled trial is being conducted in 200 patients. In both groups, "Control" and "Rehabilitation", 7 home visits are scheduled during the 3-month intervention for education purpose. In the "Rehabilitation" group, patients will receive 160 mg/d of oral testosterone undecanoate in men, 80 mg/d in women, oral dietary supplements (563 kcal/d) and exercises on an ergometric bicycle 3 to 5 times a week. EXPECTED RESULTS:In the event of significant responses to intervention, this trial would validate a comprehensive and global home-care for undernourished patients with chronic respiratory failure combining therapeutic education, oral supplements, androgenic substitution and physical activity.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Pison C,Cano N,Chérion C,Roth H,Pichard C,Investigateurs D'IRAD2.doi
10.1016/s0761-8425(04)71362-5subject
Has Abstractpub_date
2004-06-01 00:00:00pages
573-82issue
3 Pt 1eissn
0761-8425issn
1776-2588pii
MDOI-RMR-06-2004-21-3-0761-8425-101019-ART19journal_volume
21pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：INTRODUCTION:Itraconazole is an azole derivative used for the treatment of aspergillosis. Cardiac failure is a rare complication of treatment. Most cases occur in patients with cardiovascular risk factors, or taking multiple medications, and a causal relationship is not well-established. CASE REPORT:We report the case...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.08.014
更新日期：2011-03-01 00:00:00
abstract：:We report a case of eosinophilic pneumonia secondary to taking Tetracycline whose severity required the use of mechanical ventilation and steroid therapy. On the basis of this case, we review the characteristics of drug-induced pneumonia as well as the differential diagnosis which are evoked. ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The authors report a case of disseminated pulmonary histoplasmosis in an HIV positive patient who had travelled in countries where the disease was endemic. The principle clinical characteristics of the disease are reviewed including the radiology and the methods of treatment particularly in the forms occurring in this...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Exercise-induced desaturation is a well-described phenomenon in COPD patients during exercise assessments such as the six minute walk test (6MWT). Some of the pathophysiological mechanisms involved in this O2 desaturation could be modified by individualized exercise training as part of a pulmonary rehabilita...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(07)91126-2
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction (VIDD) in animal models and also in humans. BACKGROUND:The main pathophysiological pathways implicated in VIDD seems to be related to muscle inactivity but may also be the consequence of high tidal volumes. Systemic ins...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2014.08.013
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:Patients suffering from chronic obstructive pulmonary disease (COPD) are often admitted to hospital with an exacerbation of their disease that manifests itself with an increase in cough and/or sputum, increased dyspnoea and sometimes chest pain. These episodes are most often attributed to an acute exacerba...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,多中心研究
doi：10.1016/s0761-8425(04)71420-5
更新日期：2004-09-01 00:00:00
abstract：:We report on a 45-year old woman with daytime sleepiness, polycythemia, hypoxemia and hypercapnia, admitted to hospital on three occasions in a 10 month period for acute respiratory failure. Polysomnography demonstrated apneas of central type, testing of the respiratory drive suggested central alveolar hypoventilation...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:The nerve growth factor (NGF) is known as a factor involved in neuronal growth and survival. From recent studies it may also be considered as a mediator of inflammation, in particular in the airways. STATE OF ART:Several animal studies have shown that NGF may increase the sensory innervation, and particip...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(04)71290-5
更新日期：2004-04-01 00:00:00
abstract：:The authors report the results of a multi-centre trial on 500 cases of lymph-epithelial thymoma (TLE) treated by 14 surgical teams. Most typically a tumour of the adult in the fifth decade, occurring most commonly in women (60%), one in every two cases of TLE occurs in auto-immune disease: usually myasthenia. Most oft...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:Cardiopulmonary exercise testing (CPET) is used to evaluate the severity of interstitial lung diseases, particularly when lung function is normal. The aim of this study was to analyse exercise capacity of patients with alveolar proteinosis. METHODS:We studied 7 patients undergoing alveolar proteinosis (ag...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1019/200530119
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:Patients suffering from sarcoidosis sometimes report dyspnoea of effort. The restrictive or obstructive ventilatory problems contribute to this disability, but the systemic manifestations of sarcoidosis should be considered as other possible causes of the dyspnoea. CASE REPORT:We report a case of systemic...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Supportive care is the total medical, nursing and psychosocial help which the patients need besides the specific treatment. Supportive care leads to reduce morbidity and toxicity of the disease and cancer therapy, and require an optimal medical organisation. Reduction of toxicity with lung cancer chemotherapy often re...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:To update full time educated youth data on smoking prevalence related to gender and to assess perception and behaviour related to smoking, we have led a self-administrated question-study from January to June 2002 in Abidjan with students from 8 to 22 years old. METHODS:Our population was divided in 3 groups...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(04)71410-2
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Amyopathic dermatomyositis associated with anti-MDA5 autoantibodies is a rare and very recently described clinical entity. CASE REPORT:A 58-year-old woman was admitted with subacute onset of dyspnea (NYHA class IV) associated with cough, oligoarthritis of the wrists, myalgia and intermittent fever. Examin...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2014.02.010
更新日期：2014-11-01 00:00:00
abstract：:Changing incidence and nature of mycobacterial infections subsequent to the historical regression of tuberculosis and the acquired human immunodeficiency syndrome (AIDS) epidemic, as well as the development of new technical tools for molecular biology, have profoundly modified the methods used for the bacteriological ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1997-12-01 00:00:00
abstract：:Recognition of the criteria of severity and the early admission to a referral center play a critical role in the prognosis of severe haemoptysis. The therapeutic management should be undertaken urgently by providing general supportive care, i.e., optimization of oxygenation and haemodynamic stabilization to prevent re...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2010.10.006
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described. CASE REPORT:We report the case of a 56 year...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:We report the case of a 73 year old man presenting with severe hypoxaemia due to an anatomical right to left shunt from a persistent left superior vena cava (VCSG) anastomosing with the left auricle. This was fortuitously discovered while placing a left sub clavicular catheter; the diagnosis of the VCSG draining into ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：INTRODUCTION:Lung neuroendocrine large-cell carcinoma (LNELCC) is a rare tumour with a poor prognosis. There are very few guidelines for LNELCC treatment but a better knowledge of its biology could improve the treatment and prognosis of this malignancy. OBSERVATIONS:We present the cases of 2 patients who presented ini...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2016.05.010
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Interstitial lung diseases (ILD) in systemic sclerosis (SSc) are mainly encountered in patients with diffuse disease although they may occur less frequently in patients with limited cutaneous disease. BACKGROUND:In SSc early detection of ILD should be achieved by high resolution computed tomography and pu...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(07)92767-9
更新日期：2007-10-01 00:00:00
abstract：:Non malignant asbestos diseases are dominated numerically by pleural plaques. This form of circumscribed fibrosis of the parietal pleural is generally asymptomatic and its potential for evolution is weak. More rarely diffuse pleural fibrosis results from disease of the visceral pleura with a secondary fusion of the tw...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The human intestinal microbiota is composed of approximately 100,000 billion microorganisms with the average total number of different commensal bacterial species estimated at over 500 per individual. The human intestinal microbiota can be considered as an organ within another, which co-evolved with its host to achiev...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2016.11.003
更新日期：2017-12-01 00:00:00
abstract：:Bronchioloalveolar carcinoma (BAC) is a pulmonary adenocarcinoma (ADC) developing in the terminal respiratory units. The restrictive definition adopted by the 1999 WHO pathological classification requires a complete resection of the tumour to exclude any evidence of histological invasion. Although IIIB-IV tumours were...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To define the role of interventional radiology and surgery respectively, in the treatment of massive haemoptysis. GENERAL CONSIDERATIONS: For the management of massive haemoptysis in non-terminal pathologies an intensive care facility and a multi-disciplinary team are necessary. It is of paramount importance ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(05)85635-9
更新日期：2005-11-01 00:00:00
abstract：:The overall objective of this review is to analyze the literature published on artificial ventilation in cancer patients. First, we reviewed series of cancer patients treated by mechanical ventilation or intensive care series with data on artificial ventilation in a context of malignant solid tumors, hematology malign...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：:Invasive pulmonary aspergillosis is an opportunistic pneumonia which is particularly common in immuno-depressed subjects. The most frequent risk factors are the intensity and duration of leucopaenia, cytotoxic drugs and steroid therapy. In the respiratory tract, the proliferation of Aspergillus fumigatus becomes possi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Amongst the undesirable effects of medical intervention which touch on the respiratory apparatus one can distinguish schematically those disorders which affect the "passive respiratory system" (lungs, pleura, bronchi and vessels) and those which concern the "active respiratory system (SRA)" (nerve centres, respiratory...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Since 2002, Belgian law has authorized the practice of euthanasia under certain clear conditions. All cases have to be reported to the Assessment and Control Commission (ACC). To date, more than 9000 cases have been reported. AIM:To make a statement about the Belgian experience requires consideration of s...
journal_title：Revue des maladies respiratoires
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.rmr.2015.10.006
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has recently been shown to be an accurate modality in the diagnosis and staging of mediastinal lymph node metastases. This procedure takes significantly longer than a conventional bronchoscopy and may therefore cause more discomfo...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:In order to achieve mediastinal lymph node staging in bronchial cancer, axial mediastinoscopy (combined with left anterior mediastinoscopy for cancers of the left upper lobe) is by far the most efficient and the most reliable technique. Since mediastinoscopy has been part of the investigations that can be made before ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
