Abstract：
INTRODUCTION:Amyopathic dermatomyositis associated with anti-MDA5 autoantibodies is a rare and very recently described clinical entity. CASE REPORT:A 58-year-old woman was admitted with subacute onset of dyspnea (NYHA class IV) associated with cough, oligoarthritis of the wrists, myalgia and intermittent fever. Examination demonstrated skin lesions with heliotrope rash, Gottron's papules, "mechanics hands", and basal inspiratory crackles on lung auscultation. Pulmonary function tests showed a restrictive ventilatory defect, with decreased carbon monoxide diffusion capacity and marked hypoxemia (PaO2 61 mmHg). The chest high-resolution computed tomography appearances were consistent with organizing pneumonia. Bronchoalveolar lavage differential cell count demonstrated 22 % neutrophils. Serum creatine kinase and electromyography were normal ; the serum ferritin level was elevated. Antinuclear antibodies were present and anti-MDA5 autoantibodies were identified. Significant improvement was obtained with systemic corticosteroids, later converted to mycophenolate mofetil as a steroid-sparing agent. CONCLUSION:Amyopathic dermatomyositis associated with anti-MDA5 autoantibodies shares some characteristics with those associated with anti-synthetase antibodies. Muscular involvement may be mild or absent. Early diagnosis and treatment may improve outcome.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Gerfaud-Valentin M,Ahmad K,Piegay F,Fabien N,Raphanel B,Cordier JF,Cottin Vdoi
10.1016/j.rmr.2014.02.010subject
Has Abstractpub_date
2014-11-01 00:00:00pages
849-53issue
9eissn
0761-8425issn
1776-2588pii
S0761-8425(14)00075-8journal_volume
31pub_type
杂志文章abstract：:We report the case of a 73 year old man presenting with severe hypoxaemia due to an anatomical right to left shunt from a persistent left superior vena cava (VCSG) anastomosing with the left auricle. This was fortuitously discovered while placing a left sub clavicular catheter; the diagnosis of the VCSG draining into ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：INTRODUCTION:The initiation of oxygen therapy for acute or chronic respiratory failure is a common medical intervention, both for hospital in-patients and in out-of-hospital emergency settings. Oxygen therapy is also frequently initiated by paramedics or nurses, without any initial medical prescription, in acutely ill ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-01 00:00:00
abstract：:The article has as purpose to propose a systematic approach for the reading of meta-analysis. Using a particular example, a literature search is proposed to identify the two types of meta-analyses: those based on individual data of the patients and those performed in systematic reviews of the literature. The proposed ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：INTRODUCTION:Cancer and venous thromboembolism are frequently associated. STATE OF THE ART:Venous thromboembolism is associated with a worse prognosis in patients with cancer. Thrombosis in cancer patients is related to the expression of tissue factor and other procoagulants by tumour cells. Surgery, chemotherapy and ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2011.02.007
更新日期：2011-04-01 00:00:00
abstract：:Despite the progress in therapeutic strategies, overall survival of stage III non small cell lung cancers (NSCLC) is poor. Currently, the standard treatment for unresectable locally advanced NSCLC is concurrent chemoradiotherapy. However, oesophagitis is a major toxicity and this schedule should be reserved for patien...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：:The aim of this work was to study the kinetic of intramacrophage penetration of cotrimoxazole in guinea pigs which had received 100 mg/kg of sulfamethoxazole and 20 mg/kg of trimethoprim after a single intraperitoneal injection. 30 minutes, 1, 3, 6 and 24 hours after this injection an intra-cardiac blood sample was ta...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The gene of cystic fibrosis is localised on the long arm of chromosome 7. DNA probes placed close to the gene enable a study of restriction polymorphism to follow the transmission of the gene in index families. It is now possible to counsel those families, who already have an affected child, with an early antenatal di...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described. CASE REPORT:We report the case of a 56 year...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:The diagnosis of pulmonary hydatid cysts in children is generally easy and does not require endoscopic exploration, because the radiological aspects of an intact or a complicated cyst are most often suggestive. There are, nevertheless, some cases of pulmonary hydatids where the cyst is partially evacuated and then inf...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Inhaled corticosteroid is the first choice antiinflammatory therapy for chronic asthma. International guidelines are based upon data obtained in the non-smokers with asthma. The objective of this review is to highlight the interaction between cigarette smoking and metabolism of steroids and to consider the consequence...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(08)71516-x
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:The efficacy of pulmonary rehabilitation in the short term for patients with Chronic Obstructive Pulmonary Disease (COPD) is now clearly established. However, several studies have shown that these benefits last only for between 6 months to one year. On the basis of the current literature, the authors belie...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2007-02-01 00:00:00
abstract：INTRODUCTION:Epidemiological cohorts based on population samples, established in the 1990s, have helped to clarify the prevalence of obstructive sleep apnoea syndrome (OSAS) and to identify key risk factors and co-morbidities. STATE OF KNOWLEDGE:OSAS is a common disease whose prevalence increases with age. Its main ri...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2014.01.013
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:The evolution of the microbial epidemiology of pleuropulmonary infections complicating community-acquired pneumonia has resulted in a change in empirical or targeted antibiotic therapy in children in the post Prevenar 13 era. The three main pathogens involved in pleural empyema in children are Streptococcu...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2020.04.010
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Thymic epithelial tumors (TET), including thymomas and thymic carcinomas, are rare and characterized by very different evolutionary patterns depending on histology and invasion stage. The therapeutic management is not well defined but is a subject of increasing interest. The descriptive and analytic objectiv...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.09.015
更新日期：2014-09-01 00:00:00
abstract：INTRODUCTION:Breath-hold diving has been practised since the dawn of humanity but is open to many risks. The consequences mainly involve the respiratory system. The pathophysiological mechanisms are complex because of the multiple forces applied to the body during breath-hold diving. OBSERVATION:The case reported here...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(07)74263-8
更新日期：2007-11-01 00:00:00
abstract：:The authors report a case of disseminated pulmonary histoplasmosis in an HIV positive patient who had travelled in countries where the disease was endemic. The principle clinical characteristics of the disease are reviewed including the radiology and the methods of treatment particularly in the forms occurring in this...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:The insulin-like growth factor I receptor (IGF-IR) pathway plays a major role in cancer growth, tumor cell survival and resistance to therapy. BACKGROUND:Preclinical evidence that targeting the IGF-IR is effective in cancer treatment has been accumulating for almost 2 decades. Early clinical trials reveal...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2010.07.005
更新日期：2010-10-01 00:00:00
abstract：:The diagnosis and early extraction of a respiratory foreign body (FB) in a child requires a rapid bronchoscopy. Thus, the possibility of a foreign body requires an endoscopy even in the absence of clinical or radiological signs. While the sensitivity of "the foreign body syndrome" is important (79-85%) its specificity...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：:The development of fibreoptic bronchoscopy has enabled significant progress in the understanding of the pathogenesis of asthma. It has brought to the fore the importance of bronchial inflammation even in asymptomatic patients and/or in patients who have only mild disease. The practice of bronchial biopsy in vivo is an...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：:We report a case of a man aged 36, in whom a diagnosis of mucoviscidosis was diagnosed based on the association of diffuse bronchiectasis and obstructive azoospermia. We discussed some clinical and biological aspects leading to the diagnosis of mucoviscidosis in the adult. ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：UNLABELLED:Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease. INTRODUCTION:We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication i...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.09.013
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has recently been shown to be an accurate modality in the diagnosis and staging of mediastinal lymph node metastases. This procedure takes significantly longer than a conventional bronchoscopy and may therefore cause more discomfo...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2009.11.004
更新日期：2010-01-01 00:00:00
abstract：:The phospholipid content of bronchoalveolar lavage (LBA) has been little studied till now. This work involved 96 LBA on 7 cases of allergic alveolitis, 11 cases of diffuse interstitial fibrosis (FID) and 42 of sarcoidosis. The liquid collected was submitted to a cellular study (cellularity, total and differential) and...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:Venlafaxine and propranolol have rarely been identified as causes of pulmonary pathology. We describe a case of drug-induced pneumonitis occurring in a patient treated with these two medications. CASE REPORT:A 55 years old woman with liver cirrhosis treated with venlafaxine for 1 year and propranolol for ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(08)71620-6
更新日期：2008-05-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between asthma, the respiratory history and possible disturbances of pulmonary function in teenage asthmatics. This aetiological study was carried out in 103 asthmatics and 1094 controls who were teenagers attending schools in Bordeaux. In addition to the data ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The muco-ciliary apparatus has an essential role in the cleansing of the tracheo-bronchial tree of particulate matter. Disturbances linked to muco-ciliary function are well known in respiratory pathology and in cases of chronic bronchitis and asthma and lead to a reduced capacity for cleansing. In addition there are n...
journal_title：Revue des maladies respiratoires
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:Current guidelines for referring patients with idiopathic pulmonary fibrosis (IPF) for lung transplantation, based on resting parameters, are insufficient to predict 3-year mortality. The aim of this study was to determine the prognostic value of cardio-pulmonary exercise testing (CPET) in patients with IPF. A multice...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmr.2010.08.016
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Quality of life is rarely assessed in the pulmonary function laboratory. Quality of life, or at least some of its domains, should be directly measured. STATE OF ART:Quality-of-life questionnaires developed according to established protocols can be very useful in clinical practice. In clinical studies, the...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:Excessive widening of the alveolar-arterial gradient for oxygen, with respect to the subject's age and oxygen uptake, is the most sensitive signal of a disturbance in pulmonary gas exchange, whether it is due to ventilation, circulation or diffusion. During incremental exercise, simultaneous measurements of metabolic ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2012.05.018
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Cardiopulmonary exercise testing (CPET) is used to evaluate the severity of interstitial lung diseases, particularly when lung function is normal. The aim of this study was to analyse exercise capacity of patients with alveolar proteinosis. METHODS:We studied 7 patients undergoing alveolar proteinosis (ag...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1019/200530119
更新日期：2005-12-01 00:00:00
