Abstract：
INTRODUCTION:Venlafaxine and propranolol have rarely been identified as causes of pulmonary pathology. We describe a case of drug-induced pneumonitis occurring in a patient treated with these two medications. CASE REPORT:A 55 years old woman with liver cirrhosis treated with venlafaxine for 1 year and propranolol for 1 month was admitted to the intensive care unit because of acute respiratory failure. A Mycoplasma pneumoniae pneumonitis was diagnosed. After initial improvement under antibiotics, a new deterioration of respiratory status was observed 4 days after the reintroduction of venlafaxine and propranolol. Spontaneous recovery occurred after these treatments were withheld. Co administration of venlafaxine and propranolol, 2 drugs with affinity for the same cytochrome P450 isoenzyme (CYP2D6), may have contributed to drug accumulation and pulmonary toxicity. The liver cirrhosis of our patient may also have contributed to decreased cytochrome P450 enzymatic activity. CONCLUSIONS:Venlafaxine and propranolol share the same metabolic pathway and their co-administration may be complicated by drug induced pneumonitis.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Priou P,Gagnadoux F,Dehé C,Hureaux J,Person C,Urban T,Racineux JLdoi
10.1016/s0761-8425(08)71620-6subject
Has Abstractpub_date
2008-05-01 00:00:00pages
610-3issue
5eissn
0761-8425issn
1776-2588pii
S0761-8425(08)71620-6journal_volume
25pub_type
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