Abstract：
INTRODUCTION:The insulin-like growth factor I receptor (IGF-IR) pathway plays a major role in cancer growth, tumor cell survival and resistance to therapy. BACKGROUND:Preclinical evidence that targeting the IGF-IR is effective in cancer treatment has been accumulating for almost 2 decades. Early clinical trials revealed an acceptable safety profile together with pharmacodynamic evidence that the receptor can be targeted successfully. It is premature to draw conclusions regarding the therapeutic potential of this class of compounds but well-documented single-agent activity was noted during phase I evaluations, and recent evidence from a phase-II study suggests that co-administration of an anti-IGF-1R antibody with chemotherapy for non-small-cell lung cancer (NSCLC) improves objective response rate and progression-free survival. VIEWPOINTS:These early results are a strong indication for continued research on the targeting of IGF-R, particularly in the treatment of NSCLC. CONCLUSIONS:Today, IGF-1R targeting appears a promising approach, more than two dozen compounds have been developed and clinical trials are underway.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Moro-Sibilot D,Coudurier M,Lantuejoul Sdoi
10.1016/j.rmr.2010.07.005subject
Has Abstractpub_date
2010-10-01 00:00:00pages
959-63issue
8eissn
0761-8425issn
1776-2588pii
S0761-8425(10)00365-7journal_volume
27pub_type
杂志文章,评审abstract：:The authors explain the different types of legislation, according to dissimilar systems, which enable the Social Security or private services to take charge of the care required for occupationally acquired asthma. They emphasize that compensation is currently specified in the different countries by official internatio...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The occurrence of pulmonary fibrosis in numerous individuals from the same family suggests a genetic cause for the disease. During the last 10 years, mutations involving proteins from the telomerase complex and from the surfactant system have been identified in association with pulmonary fibrosis. Mutations of TERT, t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2014.07.017
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION:This review presents the state of knowledge regarding the acute and chronic toxicity of diesel engine exhaust in humans. STATE OF ART:The health effects of diesel engine exhaust, which is a complex mixture of gas and particulate matter (ultrafine and fine particles), are mainly irritation of the respirato...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2014.07.012
更新日期：2015-02-01 00:00:00
abstract：:The authors report a case of a plasma cell granuloma in a young woman of 19 with a past history of congenital rubella, presenting with repeated small haemoptyses related to a pedunculated endo-bronchial tumour. The diagnosis was only made per-operatively, permitting an effective excision. ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Mature teratomas of the mediastinum are rare. However, they represent the most common mediastinal germ cell tumours. The aim of this study is to describe their clinical and pathological characteristics. PATIENTS AND METHODS:Fourteen cases of mediastinal mature teratoma, diagnosed between January 1992 and ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(08)71610-3
更新日期：2008-05-01 00:00:00
abstract：:Currently conventional oxygen therapy is the first choice symptomatic treatment in the management of acute respiratory failure (ARF). However, conventional oxygen therapy has important limitations which have lead to the development of heated and humidified high-flow nasal oxygen therapy (HFNO). HFNO is an innovative t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2013.04.016
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:Since 2002, Belgian law has authorized the practice of euthanasia under certain clear conditions. All cases have to be reported to the Assessment and Control Commission (ACC). To date, more than 9000 cases have been reported. AIM:To make a statement about the Belgian experience requires consideration of s...
journal_title：Revue des maladies respiratoires
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.rmr.2015.10.006
更新日期：2016-10-01 00:00:00
abstract：:Inhaled medications are widely used in patients suffering from bronchial diseases. Beside their pharmacological properties, nebulised solutions have physico-chemical characteristics that can alter bronchial reactivity. Non-isotonic solutions can induce a bronchial hyperresponsiveness and/or a severe bronchonconstricti...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:Itraconazole is an azole derivative used for the treatment of aspergillosis. Cardiac failure is a rare complication of treatment. Most cases occur in patients with cardiovascular risk factors, or taking multiple medications, and a causal relationship is not well-established. CASE REPORT:We report the case...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.08.014
更新日期：2011-03-01 00:00:00
abstract：:Patients with clinical stage IIIAN2 non-small cell lung cancer (NSCLC) are a heterogeneous subgroup in term of prognosis and therapeutic management. The optimal management of this patient group is a major focus for thoracic oncology research and the concept of multimodality treatment has recently been introduced. This...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2011.05.017
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:The aim of this systematic literature review was to grade the levels of evidence of the most widely used manual airway clearance techniques. METHODS:A literature search was conducted over the period 1995-2014 from the Medline, PEDro, ScienceDirect, Cochrane Library, REEDOC and kinedoc databases, with the fo...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2015.12.004
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION:In western countries, community-acquired pneumonias due to Klebsiella pneumoniae (Kp) are rare and associated with a poor prognosis and a high mortality. The severity is in part linked to the virulence of Kp. Immuno-depression, sepsis and visceral abscesses are frequently found, constituting other classica...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(09)72429-5
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION:Light chain deposition disease is a rare anatomo-clinical disorder, which rarely leads to cystic lung destruction. CASE REPORT:We report the case of a 62years old female patient with a history of a monoclonal gammopathy of unknown significance who developed progressive dyspnea. Thoracic CT-scan demonstrat...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2020.01.001
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:This qualitative study aimed to explore the real life experience of the patients with chronic obstructive pulmonary disease (COPD) at the time they receive the diagnosis. METHODS:Data were collected using face to face interviews in general practice as well as focus groups in a pulmonary rehabilitation cen...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2018.10.007
更新日期：2019-03-01 00:00:00
abstract：:Mediastinoscopy is a technique which enables palpation, inspection and biopsy of superior mediastinal glands. When this examination is done routinely in patients suffering from lung cancer which is presumed to be operable, 25-30% are found to have a positive gland and the greater part of these individuals become inope...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:Neonatal screening for cystic fibrosis (CF) leads to early dedicated specialist care for all patients. BACKGROUND:Pulmonary function tests (PFT) are mandatory for routine monitoring of CF patients. The aim of this article is to review the current guidelines for PFTs in CF, particularly the type of test, t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(07)91145-6
更新日期：2007-06-01 00:00:00
abstract：:We report the case of a 17 year-old woman who had a pleuro-pericarditis after remission of an ulcerative colitis. The patient had a rapid and complete recovery with steroids. This extra-intestinal complication can develop during all the stages of the disease and its diagnosis can be very difficult. ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:The real cost of medical consumption was compared with the proportion of medication consumption of (the) GHM n(o) 681 (homogeneous group of patients, chemotherapy for cancer in day care) in the French case mix system (PMSI). For those patients in our thoracic oncology unit (Sainte-Marguerite Hospital, Marseille, Franc...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：INTRODUCTION:Knowledge of prognostic factors is important for therapeutic decision making but above all, at a population level, for the interpretation of data in the literature and as a guide to clinical research. To be useful in practice they must be both independent and reproducible. Despite an impressive number of p...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:This questionnaire-based epidemiological study was aimed at identifying possible sleep disturbance in a sample of active French males. METHODS:Eight hundred and fifty male subjects, aged 22 to 66 years, completed a structured sleep questionnaire supplemented by information about their life habits and medi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2010.07.003
更新日期：2010-09-01 00:00:00
abstract：:The authors report their observations on a patient presenting with Wegener's granulomatosis with initially isolated pulmonary involvement. Following treatment with a combination of steroid therapy and immunosuppressives muscular involvement developed with specific histological changes. The disease was only controlled ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:ICU set up is a complex framework in Québec. In this respect, quebecer and french systems are very different. Pulmonologists are one of the most committed sub-specialists in ICUs, either as consultant or as MD on duty. Amongst paramedics, respiratory therapists are essential members of the team. Invasive and noninvasi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:Latent tuberculosis infection is a pathophysiological and clinical entity. The diagnosis is based on immunological tests such as the tuberculin skin test or interferon-gamma release assays. Interpretation of the results depends on the clinical context. Their predictive value for the occurrence of tuberculous disease i...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2011.05.019
更新日期：2012-02-01 00:00:00
abstract：:Bronchial provocation tests are useful for the detection of subclinical bronchial hyper-reactivity. Their standardisation is vital, in particular the method of administration of the bronchoconstrictor agent. Our study compares two systems of histamine delivery: an aerosol propellant with freons and a jet nebuliser lin...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:The measures for people in specific situations such as prisoners are part of the Millennium Development Goals (MDGs). The objective of this study was to assess respiratory pathologies in a black African carceral center. METHODS:Retrospective study about the prevalence of respiratory pathologies in the arr...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2016.10.878
更新日期：2017-09-01 00:00:00
abstract：INTRODUCTION:Sleep disturbances may make smoking cessation more difficult and relapses more frequent. STATE OF THE ART:Nicotine increases vigilance and decreases sleeping time. Cigarette smoking is associated both with difficulty initiating and maintaining sleep. The disruption is associated with arousals on EEG recor...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2006-06-01 00:00:00
abstract：:Among the non malignant diseases related to asbestos exposure, pleural plaques are the most frequent. Pleural effusion and diffuse pleural thickening, as well as asbestosis, are uncommon nowadays in asbestos-exposed screened populations. Despite the absence of any useful treatment, accurate diagnoses of these diseases...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(07)78508-x
更新日期：2007-12-01 00:00:00
abstract：:The muco-ciliary apparatus has an essential role in the cleansing of the tracheo-bronchial tree of particulate matter. Disturbances linked to muco-ciliary function are well known in respiratory pathology and in cases of chronic bronchitis and asthma and lead to a reduced capacity for cleansing. In addition there are n...
journal_title：Revue des maladies respiratoires
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-01-01 00:00:00
abstract：:Despite the progress in therapeutic strategies, overall survival of stage III non small cell lung cancers (NSCLC) is poor. Currently, the standard treatment for unresectable locally advanced NSCLC is concurrent chemoradiotherapy. However, oesophagitis is a major toxicity and this schedule should be reserved for patien...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Lung hyperinflation (LH) has become a major concern in the management of chronic obstructive pulmonary disease (COPD). MAIN AIM:To evaluate the role of lung volumes in the positive diagnosis of COPD and in the assessment of airway obstruction reversibility. POPULATION AND METHODS:Three hundred and sixty-...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.05.009
更新日期：2014-01-01 00:00:00
