Abstract：
:Inhaled medications are widely used in patients suffering from bronchial diseases. Beside their pharmacological properties, nebulised solutions have physico-chemical characteristics that can alter bronchial reactivity. Non-isotonic solutions can induce a bronchial hyperresponsiveness and/or a severe bronchonconstriction. Nevertheless, multiple drugs are used for nebulisation despite their unknown osmolarity. The aim of this study was to measure the tonicity of drug solutions commonly used for nebulisation in patients suffering from bronchial disease. Drug solutions were prepared either according to manufacturer recommendations or by diluting the stock in 5 ml of NaCl (0.9%) or H2CO3 (0.14%). Although bronchodilatator solutions (i.e. salbutamol, terbulatine, ipratropium bromide) were nearly isotonic, some drugs prepared for nebulisation had either a very high (e.g. mesna, netilmicine) or a very low (e.g. gomenol, sodium cromoglycate) tonicity. These values may be responsible for bronchoconstriction. Some hypertonic solutions, prepared with drugs such as acetylcytein or netilmycin, are not commercialised for nebulisation but are commonly used for aerosol therapy. In addition, solutions initially isotonic could become significantly hypertonic towards the end of nebulisation. Taken together, these results suggest that non-isotonic solutions should be used with caution specially in patients with bronchial hyperresponsiveness, even when aerosol therapy is prescribed for upper airways.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Portel L,Tunon de Lara JM,Vernejoux JM,Weiss I,Taytard Asubject
Has Abstractpub_date
1998-04-01 00:00:00pages
191-5issue
2eissn
0761-8425issn
1776-2588journal_volume
15pub_type
杂志文章abstract：:Changing incidence and nature of mycobacterial infections subsequent to the historical regression of tuberculosis and the acquired human immunodeficiency syndrome (AIDS) epidemic, as well as the development of new technical tools for molecular biology, have profoundly modified the methods used for the bacteriological ...
journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
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更新日期：2000-06-01 00:00:00
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journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
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更新日期：1987-01-01 00:00:00
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journal_title：Revue des maladies respiratoires
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更新日期：1997-01-01 00:00:00
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journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
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journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
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journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Revue des maladies respiratoires
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doi：10.1016/j.rmr.2014.07.017
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journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
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doi：
更新日期：1996-01-01 00:00:00
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journal_title：Revue des maladies respiratoires
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doi：10.1016/j.rmr.2020.04.004
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journal_title：Revue des maladies respiratoires
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journal_title：Revue des maladies respiratoires
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更新日期：2014-05-01 00:00:00
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journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The authors report an "analytic epidemiological" study, showing the risk of relapse in tuberculous patients in the Bas-Rhin in 1967 to 1977. This was possible thanks to statutory notification of tuberculous cases, with an index updated by annual returns. The study relates to French subjects notified as new cases of al...
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doi：
更新日期：1984-01-01 00:00:00
