Rat liver DT-diaphorase: regulation of functional mRNA levels by 3-methylcholanthrene, trans-stilbene oxide, and phenobarbital.

abstract：:Kirsten murine sarcoma virus-transformed Balb/c 3T3 cells (KiMSV) are highly tumorigenic and metastatic in the appropriate murine host, are loosely adherent to the tissue culture substratum, and can be readily detached from the substratum by ethylene glycol bis(beta-aminoethyl ether) N,N'-tetraacetic acid treatment le...

journal_title：Archives of biochemistry and biophysics

authors： Miketo LJ,Culp LA

更新日期：1983-03-01 00:00:00

abstract：:Oxygenation of a tryptophan residue analog by ascorbate in the presence of catalytic amounts of iron(II) and ethylenediaminetetraacetic acid (EDTA) has been studied. Under physiological conditions, reaction of the tryptophan derivative (N-t-butoxycarbonyl-L-tryptophan) with Fe(II)-EDTA and ascorbate resulted mainly in...

journal_title：Archives of biochemistry and biophysics

authors： Uchida K,Enomoto N,Itakura K,Kawakishi S

更新日期：1990-05-15 00:00:00

abstract：:In spite of the abundance of antifungal therapies, 75% of women in the world suffer from the second most common cause of vaginal infection named vulvovaginal candidiasis. This complication is characterized with overgrowth of Candida albicans. The low efficacy and side effects of current antifungal therapies have convi...

journal_title：Archives of biochemistry and biophysics

authors： Ebrahimi-Shaghaghi F,Noormohammadi Z,Atyabi SM,Razzaghi-Abyaneh M

更新日期：2021-01-22 00:00:00

abstract：:Primary carnitine deficiency is an autosomal recessive disorder caused by defective carnitine transport which impairs fatty acid oxidation and manifests as nonketotic hypoglycemia or skeletal or heart myopathy. Here we report the functional characterization of this transporter in human fibroblasts. Carnitine enters no...

journal_title：Archives of biochemistry and biophysics

authors： Scaglia F,Wang Y,Longo N

更新日期：1999-04-01 00:00:00

abstract：:Phagocytes generate superoxide (O2-.) and hydrogen peroxide (H2O2) and their interaction in an iron-catalyzed reaction to form hydroxyl radicals (OH.) (Haber-Weiss reaction) has been proposed. Deferoxamine chelates iron in a catalytically inactive form, and thus inhibition by deferoxamine has been employed as evidence...

journal_title：Archives of biochemistry and biophysics

authors： Klebanoff SJ,Waltersdorph AM

更新日期：1988-08-01 00:00:00

abstract：:The cDNA clone lambda ML-1 encoding one of the extracellular lignin peroxidases from the white rot fungus, Phanerochaete chrysosporium, was heterologously expressed in an active form using a recombinant baculovirus system. The glycosylated extracellular form of the recombinant protein contained the ferriprotoporphyrin...

journal_title：Archives of biochemistry and biophysics

authors： Johnson TM,Li JK

更新日期：1991-12-01 00:00:00

abstract：:Superoxide generation, assessed as the rate of acetylated cytochrome c reduction inhibited by superoxide dismutase, by purified NADPH cytochrome P-450 reductase or intact rat liver microsomes was found to account for only a small fraction of their respective NADPH oxidase activities. DTPA-Fe3+ and EDTA-FE3+ greatly st...

journal_title：Archives of biochemistry and biophysics

authors： Morehouse LA,Thomas CE,Aust SD

更新日期：1984-07-01 00:00:00

abstract：:The objective of this study was to determine if oxidative stress/damage is a possible causal factor in the senescence-related loss of brain functions in the mouse. If such a relationship indeed existed, it was expected that oxidative protein damage would increase with age within regions of the brain associated with se...

journal_title：Archives of biochemistry and biophysics

authors： Dubey A,Forster MJ,Lal H,Sohal RS

更新日期：1996-09-01 00:00:00

abstract：:Xanthine dehydrogenase was purified from soybean nodules and the kinetic properties were studied at pH 7.5. Km values of 5.0 +/- 0.6 and 12.5 +/- 2.5 microM were obtained for xanthine and NAD+, respectively. The pattern of substrate dependence suggested a Ping-Pong mechanism. Reaction with hypoxanthine gave Km's of 52...

journal_title：Archives of biochemistry and biophysics

authors： Boland MJ,Blevins DG,Randall DD

更新日期：1983-04-15 00:00:00

abstract：:Lipoxygenases react with hydroperoxy fatty acids and catalyze dioxygenase or dehydrase (leukotriene A4 (LTA4) synthase) types of reactions. In the present investigation we studied the mechanism of reaction of the purified porcine leukocyte 12S-lipoxygenase with 15S-hydroperoxyeicosatetraenoic acid (15S-HPETE). Oxygen-...

journal_title：Archives of biochemistry and biophysics

authors： Brash AR,Yokoyama C,Oates JA,Yamamoto S

更新日期：1989-09-01 00:00:00

abstract：:The effect of phenothiazines (trifluoperazine, chlorpromazine, methochlorpromazine, and imipramine) on Ca2+ fluxes in light and heavy sarcoplasmic reticulum (SR) isolated from rabbit fast-twitch skeletal muscle was investigated. These drugs inhibited Ca2+ loading and (Ca2+,Mg2+)-ATPase activity, but had no effect on u...

journal_title：Archives of biochemistry and biophysics

authors： Volpe P,Costello B,Chu A,Fleischer S

更新日期：1984-08-15 00:00:00

abstract：:Among the biologically and pharmacologically relevant nitrogen oxides, nitroxyl (HNO) remains one of the most poorly studied and least understood. Several previous reports indicate that thiols may be a primary target for the biological actions of HNO. However, the intimate details of the chemical interaction of HNO wi...

journal_title：Archives of biochemistry and biophysics

authors： Cook NM,Shinyashiki M,Jackson MI,Leal FA,Fukuto JM

更新日期：2003-02-01 00:00:00

abstract：:A current hypothesis explaining the aging process implicates the accumulation of oxidized protein in animal tissues. This is primarily based on a series of reports showing an age-dependent increase in protein carbonyl content and an age-dependent decrease in the activities of enzymes, especially of alkaline proteases,...

journal_title：Archives of biochemistry and biophysics

authors： Cao G,Cutler RG

更新日期：1995-06-20 00:00:00

abstract：:Based on previous findings of increased nitric oxide synthase (NOS) expression in human gliomas (4), we hypothesized that peroxynitrite, a highly reactive metabolite of nitric oxide (NO) and superoxide (O(*-)(2)), might be increased in these tumors in vivo. Here we demonstrate that nitrotyrosine (a footprint of peroxy...

journal_title：Archives of biochemistry and biophysics

authors： Cobbs CS,Samanta M,Harkins LE,Gillespie GY,Merrick BA,MacMillan-Crow LA

更新日期：2001-10-15 00:00:00

abstract：:Complete structures are described for three urinary oligodextrins from one patient with type II and one patient with type III glycogen storage disease. GLC-MS, direct probe MS, and 1H NMR demonstrate two heptasaccharides and one hexasaccharide containing only alpha 1-4 and alpha 1-6 linkages. The observation that all ...

journal_title：Archives of biochemistry and biophysics

authors： Kumlien J,Grönberg G,Nilsson B,Månsson O,Zopf D,Lundblad A

更新日期：1989-03-01 00:00:00

abstract：:The modulation of the plasma membrane calcium pump (PMCA) gene expression is not well understood. We now present evidence that PMCA mRNA is induced by various hormones or agonists via multiple second messenger pathways that include protein kinase C-, cAMP-, and Ca(2+)-dependent mechanisms. Among several types of cultu...

journal_title：Archives of biochemistry and biophysics

authors： Kuo TH,Liu BF,Diglio C,Tsang W

更新日期：1993-09-01 00:00:00

abstract：:The cross-reactivity of the monoclonal anti-human placental DNA methyltransferase antibody M2B10 with DNA methyltransferases isolated from other species was investigated. This antibody immunoprecipitates DNA methyltransferases from mammalian cells, i.e., human placenta, mouse P815 cells, and rat liver cells. No cross-...

journal_title：Archives of biochemistry and biophysics

authors： Pfeifer GP,Kohlmaier L,Tomassetti A,Schleicher R,Follmann H,Pfohl-Leszkowicz A,Dirheimer G,Drahovsky D

更新日期：1989-01-01 00:00:00

abstract：:Tripeptidyl-peptidase II (TPP II) is a cytosolic peptidase that has been implicated in fat formation and cancer, apparently independent of the enzymatic activity. In search for alternative functional regions, conserved motifs were identified and eleven signatures were constructed. Seven of the signatures covered previ...

journal_title：Archives of biochemistry and biophysics

authors： Eriksson S,Gutiérrez OA,Bjerling P,Tomkinson B

更新日期：2009-04-01 00:00:00

abstract：:An alkaline proteinase, identical to mast cell chymase, has been described by a number of laboratories as being associated with myofibrils extracted from adult rat skeletal muscle tissue. A more recent study has indicated that chymase may be an intrinsic protein in the rat myocyte. The present study of rat myogenic ce...

journal_title：Archives of biochemistry and biophysics

authors： Hartz PA,Bird JW

更新日期：1988-06-01 00:00:00

abstract：:M. Kuwajima, C. B. Newgard, D. W. Foster, and J. D. McGarry (1986, J. Biol. Chem. 261, 8849-8853) have concluded that the reason postprandial hepatic glycogenesis occurs primarily from gluconeogenic precursors rather than glucose is because glucokinase activity is insufficient to support the observed rates of glycogen...

journal_title：Archives of biochemistry and biophysics

authors： Davidson AL,Arion WJ

更新日期：1987-02-15 00:00:00

abstract：:A technique is presented for the preparation of three major proteoglycans from 14-day embryonic chicken retinas following their culture overnight with [35S]sulfate and either [3H]glucosamine or [3H]serine. Homogenization of the tissue in saline permitted extraction of heterogeneous soluble proteoglycans separately fro...

journal_title：Archives of biochemistry and biophysics

authors： Morris JE

更新日期：1984-11-15 00:00:00

abstract：:Using proton NMR, the solution conformation of the A ring of vitamin D3 and its analogs has been studied by application of the Karplus relation to the observed coupling constants. The A-ring conformations of vitamins D3, D2, and 25-hydroxyvitamin D3 were found to be solvent dependent, with a clear preference for an eq...

journal_title：Archives of biochemistry and biophysics

authors： Helmer B,Schnoes HK,DeLuca HF

更新日期：1985-09-01 00:00:00

abstract：:An inhibitor protein of the catalytic subunit of the cyclic 3',5'-AMP-dependent protein kinase from the nematode Ascaris suum was isolated and characterized. The molecular weight of the inhibitor was estimated as 28,000 by electrophoresis under denaturing conditions and as 30,000 by gel permeation chromatography on Su...

journal_title：Archives of biochemistry and biophysics

authors： Hoffmann R,Jung S,Hofer HW

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The main functions of the skin are to protect against environmental insults and prevent water loss, which are performed by the complex lipid- and protein matrix present in the outermost layers of the epithelium. The lipidome of these outer layers is mainly composed of ceramides, fatty acids, and cholesterol,...

journal_title：Archives of biochemistry and biophysics

authors： Muresan XM,Narzt MS,Woodby B,Ferrara F,Gruber F,Valacchi G

更新日期：2019-05-15 00:00:00

abstract：:Vanadate V(V) markedly stimulated the oxidation of NADPH by GSSG reductase and this oxidation was accompanied by the consumption of O2 and the accumulation of H2O2. Superoxide dismutases completely eliminated this effect of V(V), whereas catalase was without effect, as was exogenous H2O2 added to 0.1 mM. These effects...

journal_title：Archives of biochemistry and biophysics

authors： Liochev SI,Fridovich I

更新日期：1992-05-01 00:00:00

abstract：:Studies of modification of hemoglobin and of sickle hemoglobin by alternative aspirins have been extended to a series of new bis esters with a variety of substituted bridging diacids and to a group of mono esters with polar acyl groups. Rates of hydrolysis of these alternative aspirins have also been examined, and the...

journal_title：Archives of biochemistry and biophysics

authors： Delaney EJ,Massil SE,Shi GY,Klotz IM

更新日期：1984-02-01 00:00:00

abstract：:While molecular adaptation to high temperature has been extensively studied, the effect of hydrostatic pressure on protein structure and enzymatic activity is still poorly understood. We have studied the influence of pressure on both the quaternary structure and enzymatic activity of the dodecameric TET3 peptidase fro...

journal_title：Archives of biochemistry and biophysics

authors： Rosenbaum E,Gabel F,Durá MA,Finet S,Cléry-Barraud C,Masson P,Franzetti B

更新日期：2012-01-15 00:00:00

abstract：:Glyceraldehyde (GA) has been used to study insulin secretion for decades and it is widely assumed that beta-cell metabolism of GA after its phosphorylation by triokinase is similar to metabolism of glucose; that is metabolism through distal glycolysis and oxidation in mitochondria. New data supported by existing infor...

journal_title：Archives of biochemistry and biophysics

authors： MacDonald MJ,Chaplen FW,Triplett CK,Gong Q,Drought H

更新日期：2006-03-15 00:00:00

abstract：:Cellobiose dehydrogenase (CDH), an extracellular hemoflavoenzyme produced by the cellulose-degrading cultures of Phanerochaete chrysosporium, oxidizes cellobiose to cellobionolactone. CDH has been purified to homogeneity by a five-step purification procedure. The homogeneous CDH is monomeric and has a relative molecul...

journal_title：Archives of biochemistry and biophysics

authors： Bao W,Usha SN,Renganathan V

更新日期：1993-02-01 00:00:00

abstract：:NADH:cytochrome b5 oxidoreductase catalyzes the transfer of reducing equivalents from the physiological electron donor, NADH, to two molecules of cytochrome b5. Utilizing a heterologous expression system for the soluble, catalytic domain of the rat microsomal enzyme, we have produced two mutants, corresponding to E255...

journal_title：Archives of biochemistry and biophysics

authors： Davis CA,Barber MJ

更新日期：2004-05-15 00:00:00