Abstract:
:Urinary C-peptide (UCP) is a noninvasive measure of integrated insulin production, and the usefulness of 24-h collections has been previously reported. Only small numbers of subjects have been studied using shorter urine collections. To see how well 4-h urine collections for C-peptide (UCP) correlate with serum immunoreactive insulin (SI) and plasma C-peptide (PCP), we studied 41 healthy subjects (19 men, 22 women) using as a stimulus a 600-kcal mixed meal and the same mixed meal after oral prednisone. UCP values correlated best with the area under the curves for SI (r = 0.457, P less than 0.001) and PCP (r = 0.557, P less than 0.001). UCP was also significantly correlated with peak SI (r = 0.382, P less than 0.001), peak PCP (r = 0.496, P less than 0.001), fasting SI (r = 0.297, P = 0.007), and fasting PCP (r = 0.341, P = 0.007) values. Urinary C-peptide was significantly correlated with SI and PCP concentrations in a broad range of physiologic values for SI and PCP supporting the usefulness of UCP as a simple, noninvasive measure of beta-cell function. Four-hour collections for UCP may be useful in further studies of beta-cell function.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Hoogwerf BJ,Barbosa JJ,Bantle JP,Laine D,Goetz FCdoi
10.2337/diacare.6.5.488subject
Has Abstractpub_date
1983-09-01 00:00:00pages
488-92issue
5eissn
0149-5992issn
1935-5548journal_volume
6pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract::The objective of this study was to define the workforce needs for the specialty of Endocrinology, Diabetes, and Metabolism in the United States between 1999 and 2020. An interactive model of factors likely to influence the balance between the supply and demand of endocrinologists during the next 20 years was construct...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.5.1545
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare two analog insulin therapies (prandial premixed therapy [PPT] versus basal/bolus therapy [BBT]) in type 2 diabetic patients previously treated with insulin glargine (>or=30 units/day) plus oral agents, with the aim of demonstrating noninferiority of PPT to BBT. RESEAR...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc07-1122
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To examine whether the association between gestational diabetes mellitus (GDM) and BMI category varies by racial/ethnic group. RESEARCH DESIGN AND METHODS:In a cohort of 123,040 women without recognized pregravid diabetes who delivered babies between 1995 and 2006 at Kaiser Permanente of Northern California,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-2267
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc14-2585
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of two doses of once-weekly dulaglutide, a glucagon-like peptide 1 receptor agonist, to sitagliptin in uncontrolled, metformin-treated patients with type 2 diabetes. The primary objective was to compare (for noninferiority and then superiority) dulaglutide 1.5 mg versus sita...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-2761
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether a strategy of aggressive cardiovascular risk management reduced the mortality associated with diabetic foot ulceration. RESEARCH DESIGN AND METHODS:After an initial audit of outcomes demonstrating a high mortality rate in 404 diabetic foot ulcer patients wit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1242
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. We investigated whether dietary fat, which modula...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc08-1741
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Sulfonylureas block the activation of vascular potassium-dependent ATP channels and impair the vasodilating response to ischcmia in nondiabetic individuals, but it is not know whether this occurs in type 2 diabetic patients under chronic treatment with these drugs. Glimepiride, a new sulfonylurea, apparently ...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.24.4.738
更新日期:2001-04-01 00:00:00
abstract::Mortality rates of two cohorts of patients with diabetes mellitus are estimated and compared. The Atlanta cohort is defined as all black patients receiving care at the diabetes clinic of Grady Memorial Hospital for the first time during calendar year 1971. The Memphis cohort is defined as all black patients referred f...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.6.4.341
更新日期:1983-07-01 00:00:00
abstract::The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Co...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc18-S009
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To establish the statistical significance of observed variations over the last decade in the incidence of insulin-dependent diabetes mellitus (IDDM) in the 0- to 19-yr-old age-group and to determine whether incidence has increased in Canterbury, New Zealand. RESEARCH DESIGN AND METHODS:The Canterbury, New Z...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.15.7.895
更新日期:1992-07-01 00:00:00
abstract::Diabetic retinopathy is the leading cause of visual impairment and preventable blindness, and represents a significant socioeconomic cost for health care systems worldwide. Therefore, new approaches beyond current standards of diabetes care are needed. Based on the crucial pathogenic role of vascular endothelial growt...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/dc13-2002
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To assess performance of nonfasting tests to screen children for dysglycemia (prediabetes or diabetes). RESEARCH DESIGN AND METHODS:This was a cross-sectional study of 254 overweight or obese (BMI ≥85th percentile) children aged 10-17 years. Subjects came for two visits to a clinical research unit. For visit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-0827
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1321
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Obesity is a well-known risk factor for vitamin D deficiency. We evaluated the interrelationship between vitamin D status, body size, and glucose homeostasis, measured by HbA1c (A1C). RESEARCH DESIGN AND METHODS:Data are from the survey of the 45-year-old 1958 British birth cohort (2002-2004). Information on...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-0946
更新日期:2006-10-01 00:00:00
abstract::In a patient with hyperthyroidism and newly diagnosed insulin-dependent diabetes mellitus (IDDM), insulin action and clearance were studied before the initiation of antithyroid treatment and at 3-mo intervals for 1 yr thereafter. The sequential euglycemic clamp technique (5 mM) was used with insulin infusion rates of ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.5.319
更新日期:1989-05-01 00:00:00
abstract::Biosynthetic human insulin (BHI) was compared with highly purified human pancreatic and pork insulin with regard to its ability to bind to erythrocytes of normal and insulin-dependent diabetic subjects (type I diabetes). The binding affinity or capacity of erythrocyte from both normal and diabetic subjects were compar...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.4.2.215
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc11-0297
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Some children with type 1 diabetes may be at risk of cognitive impairments, but mechanisms of this effect have not been confirmed. The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months. RESEARCH DESIG...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.4.1100
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemin...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc16-0954
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.28.7.1751
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.18.6.761
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to elucidate whether serum adiponectin is associated with progression of diabetic nephropathy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:This was a prospective follow-up study as a part of the nationwide Finnish Diabetic Nephropathy Study; 1,330 type 1 diabetic pat...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc07-2306
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:The objective of the present analysis was to evaluate the association of alanine aminotransferase (ALT) with directly measured insulin sensitivity (S(i)) in a large, multiethnic cohort of U.S. adults and to determine whether ALT adds to existing metabolic risk definitions in identifying subjects with insulin ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc07-0086
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc15-1385
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that lower vital capacity is cross-sectionally associated with features of insulin resistance and is an independent predictor of incident type 2 diabetes. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of vital capacity as a predictor of incident type 2 diabetes us...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.28.6.1472
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Hypertriglyceridemia is associated with cardiovascular disease in diabetes. Fibrates effectively lower, but do not always normalize, serum triglyceride levels. Fish oil supplements may then be added to lower serum triglyceride levels. Doubt remains whether the net effect of fish oil intake on glycemic control...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析
doi:10.2337/diacare.21.4.494
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity. RESEARCH DESIGN AND METHODS:We performed an analysis of data from participants who attended the morning examination of the Third National Health and Nutrition Examination Survey (1988-...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.27.12.2813
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS:An observational evaluation of possible factors related to glycemic management and performance ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc19-2302
更新日期:2020-05-01 00:00:00
abstract::The risk of severe hypoglycemia associated with the particular therapeutic approach of two University hospitals was assessed in 96% of all patients with insulin-dependent diabetes mellitus (IDDM) who had been admitted during a period of almost 3 yr to the diabetic wards of two hospitals and who participated in a struc...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.8.3.268
更新日期:1985-05-01 00:00:00