Abstract:
OBJECTIVE:Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemingly disparate rates of diabetes remission reported in studies of Roux-en-Y gastric bypass (RYGB) surgery. It examines variation in the methodologies used to derive the estimates and proposes outcomes that should be reported by all studies. RESEARCH DESIGN AND METHODS:A literature review yielded 10 large (n > 100), recent (index surgery since 2000) studies of diabetes remission after RYGB. These studies differed in definitions of remission (partial vs. complete), lengths of follow-up (1 year vs. ≥3 years), reported outcomes (cumulative vs. prevalent remission), and risks of attrition bias. RESULTS:Reported rates of partial remission were 10-30 percentage points higher than rates of complete remission. Study duration explained 69% of the variability in cumulative remission rates, plateauing at 3 years. Adjustment for attrition increased the explained variability to 87%. Attrition-adjusted, 3-year cumulative, complete remission rates ranged from 63 to 65%; however, this does not account for relapse. Attrition-adjusted, 3-year prevalent complete remission rates that accounted for relapse were 23%. CONCLUSIONS:Variations in reported rates of diabetes remission after RYGB are primarily related to definitions and study duration. Future studies should report both cumulative and prevalent remission to aid decision making and more easily compare studies.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
Isaman DJ,Rothberg AE,Herman WHdoi
10.2337/dc16-0954subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2247-2253issue
12eissn
0149-5992issn
1935-5548pii
dc16-0954journal_volume
39pub_type
杂志文章相关文献
DIABETES CARE文献大全abstract:OBJECTIVE:Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied. RESEARCH DESIGN AND METHODS:This article reports a planned secondary analysis of SF in 90 patie...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-1714
更新日期:2011-02-01 00:00:00
abstract::We have developed computer programs in compiled BASIC for the IBM-PC and compatible microcomputers for use by physicians, paramedical personnel, and/or patients to assist with self-monitoring of blood glucose (SMBG) and self-adjustment of insulin dosage. The programs can potentially assist with patient education and m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.9.1.61
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence. RESEARCH DESIGN AND METHODS:Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections pe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1631
更新日期:2019-06-01 00:00:00
abstract::It would be advantageous to be able to measure glycosylated hemoglobin (GHb) from a sample of blood dried on paper and sent to the physician by the patient. Indeed, such a technique has been introduced by Isolab (Akron, OH). We tested the validity of the method to determine whether applying the blood to paper and imme...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.10.3.352
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Longitudinal changes in GAD antibody (Ab) and ICA512/IA-2 (ICA512) Ab were examined in relation to age at the onset of diabetes and autoimmunity against the thyroid gland. RESEARCH DESIGN AND METHODS:GADAb, ICA512Ab, and antithyroid autoantibody were examined at onset in 40 juvenile-onset IDDM patients (17 m...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.1.49
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to chan...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc14-0297
更新日期:2014-10-01 00:00:00
abstract::Compared with control subjects, non-insulin-dependent diabetes mellitus (NIDDM) subjects had both quantitative and qualitative abnormalities in blood insulin and glucose concentrations. The purpose of this study was to determine whether and to what extent normally observed multiphasic patterns of insulin and glucose r...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.10.709
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea. RESEARCH DESIGN AND METHODS:Subjects (aged 47 +/- 11 years, BMI 31 +/- 5 kg/m(2),...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc06-0564
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this paper is to estimate the impact of diabetes on survival among patients with first acute myocardial infarction, using data from the World Health Organization (WHO) Monitoring Trends and Determinants of Cardiovascular Disease (MONICA) Project in Newcastle, New South Wales, Australia. RESEAR...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.20.5.704
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:The primary outcome is to evaluate the relationship between diabetes distress and decisional conflict regarding diabetes care in patients with diabetes and two or more comorbidities. Secondary outcomes include the relationships between diabetes distress and quality of life and patient perception of chronic il...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc18-1256
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To explore the relationship between the genetic polymorphisms of PPARgamma (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARgamma would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0717
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc06-0560
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with ginseng (100 or 200 mg) or placebo. Efficacy was evaluated with psychoph...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2337/diacare.18.10.1373
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:This systematic review and meta-analysis of randomized controlled trials (RCTs) assesses the effect of pharmacist care on cardiovascular disease (CVD) risk factors among outpatients with diabetes. RESEARCH DESIGN AND METHODS:MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials were...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc12-0369
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.8.1179
更新日期:1993-08-01 00:00:00
abstract:OBJECTIVE:To examine patients' views of the acceptability of and satisfaction with telephone care center support provided to improve blood glucose control in type 2 diabetes. RESEARCH DESIGN AND METHODS:The Pro-Active Call-Center Treatment Support (PACCTS) Trial randomized patients from 47 general practices in a depri...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diacare.28.2.283
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To compare the glycemic profiles of patients with type 1 diabetes treated with either an implantable insulin pump or pancreas or islet transplantation by the means of the continuous glucose monitoring system (CGMS; Minimed, Sylmar, CA). RESEARCH DESIGN AND METHODS:The CGMS enabled recording of subcutaneous g...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.25.12.2256
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To determine the short-term muscular endurance and working capacity of leg muscles in long-term IDDM patients in relation to neuropathic complications, muscle strength, and metabolic control. RESEARCH DESIGN AND METHODS:The muscular endurance of extensors and flexors at the ankle and knee was assessed in 44 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.21.4.604
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2105
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.16.11.1427
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship of impaired glucose tolerance (IGT) at baseline to coronary heart disease (CHD) incidence, and cardiovascular disease (CVD) and total mortality at follow-up, and to analyze whether the relationship is independent of the subsequent development of diabetes during follow-up. RESEARC...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.26.10.2910
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To assess the dose-ranging efficacy and safety of LX4211, a dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in type 2 diabetes. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients inadequately controlled on metformin were randomly assigned to 75 mg once daily, 200 mg once daily, 200 mg tw...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc14-0890
更新日期:2015-03-01 00:00:00
abstract::This study examined the effect of age on the posthepatic delivery of oral glucose (PHDG) during steady-state conditions. We used an intravenous-oral modification of the euglycemic insulin-clamp technique to assess PHDG in six men aged 24-39 yr (young) and eight men aged 65-83 yr (old). Each subject underwent two studi...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.12.6.394
更新日期:1989-06-01 00:00:00
abstract::The purpose of the study was to assess the value of 24-h urinary estriols in the management of diabetic pregnancies. Twenty-seven pregnant diabetic patients (White's class B through R) received insulin dosages twice daily as a combination of NPH and regular insulin. Laboratory and home monitored blood glucose was main...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.5.3.316
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey. RESEARCH DESIGN AND METHODS:History and laboratory data, including islet-related autoantibodies, were examined in 222 patients with fulminant and nonful...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/diacare.26.8.2345
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To determine whether folate metabolism in pregnant diabetic women is significantly different from that in pregnant nondiabetic women, thus predisposing them to having offspring with major congenital anomalies. RESEARCH DESIGN AND METHODS:A total of 31 pregnant diabetic women and 54 pregnant nondiabetic contr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.22.7.1017
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetes may differ according to ethnicit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc11-1547
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulce...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc06-2209
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To examine medical and mental health care expenditures for large numbers of individuals with diabetes enrolled in employment-sponsored insurance plans. RESEARCH DESIGN AND METHODS:Health insurance billing data for approximately 1.3 million individuals enrolled in health insurance plans sponsored by 862 large...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/diacare.25.11.1964
更新日期:2002-11-01 00:00:00
abstract::Intensive insulin therapy is best defined as a comprehensive system of diabetes management with the patient and management team as partners. The system is directed at improvement of glycemia and patient well-being. Glycemic targets should be individually defined. Frequent self-monitoring of blood glucose, probably at ...
journal_title:Diabetes care
pub_type: 杂志文章,评审
doi:10.2337/diacare.13.12.1265
更新日期:1990-12-01 00:00:00