Abstract:
OBJECTIVES:We aimed to investigate left ventricular (LV) morphology and function in normotensive offspring of subjects with essential hypertension (familial trait - FT), and to determine the association between LV mass and determinants of LV diastolic function and endothelium-dependent (NO-mediated) dilation of the brachial artery (BA). MATERIALS AND METHODS:The study encompassed 76 volunteers of whom 44 were normotonics with FT aged 28-39 (mean 33) years and 32 age-matched controls without FT. LV mass and LV diastolic function was measured using conventional echocardiography and tissue Doppler imaging (TDI). LV diastolic filling properties were assessed and reported as the peak E/A wave ratio, and peak septal annular velocities (E(m) and E(m)/A(m) ratio) on TDI. Using high-resolution ultrasound, BA diameters at rest and during reactive hyperaemia (flow-mediated dilation--FMD) were measured. RESULTS:In subjects with FT, the LV mass index was higher than in controls (92.14+/-24.02 vs 70.08+/-20.58); p<0.001). Offspring of hypertensive families had worse LV diastolic function than control subjects (lower E/A ratio, lower E(m) and E(m)/A(m) ratio; p<0.001). In subjects with FT, FMD was decreased compared with the controls (6.11+/-3.28% vs 10.20+/-2.07%; p<0.001). LV mass index and E(m)/A(m) ratio were associated with FMD (p<0.001). CONCLUSIONS:In normotensive individuals with FT, LV morphological and functional changes were found. We demonstrated that an increase in LV mass and alterations in LV diastolic function are related to endothelial dysfunction.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Zizek B,Poredos Pdoi
10.1080/08037050701189941subject
Has Abstractpub_date
2007-01-01 00:00:00pages
36-44issue
1eissn
0803-7051issn
1651-1999pii
777345422journal_volume
16pub_type
杂志文章相关文献
BLOOD PRESSURE文献大全abstract::Medullipin I (Med I) is a vasodepressor prohormone which is continuously elaborated into the renal venous effluent (RVE) of isolated rat kidneys perfused under high pressure. We have improved the yield of Med I by substituting saline for the albumin perfusate previously reported; and considerably improved refinement b...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102295
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. METHODS:We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050500339275
更新日期:2005-01-01 00:00:00
abstract::The Hypertension and Diabetes Screening and Awareness (HYDRA) study is a cross-sectional point-prevalence study performed in September 2001; 45,125 primary care attendees were recruited from a representative nationwide sample of 1912 primary care practices in Germany. Around 42% of all patients presenting in these pra...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310030982
更新日期:2004-01-01 00:00:00
abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.495859
更新日期:2010-12-01 00:00:00
abstract:UNLABELLED:Resistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance to antihypertensive treatment and cardiovascular complications. Biophysical forces within the arterial wall provide functional regulation of arterial stiffness. Caroti...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2011.617045
更新日期:2012-02-01 00:00:00
abstract::The familial aggregation of hypertension is well documented. However, many studies on the familial predisposition have suffered from insufficient knowledge of parental blood pressure (BP). In the present study, the family history is defined according to parental data from two BP surveys conducted almost 30 years apart...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209077668
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:To determine the clinical profile and blood pressure (BP) control rates of anticoagulated patients with hypertension and atrial fibrillation (AF). METHODS:The PAULA study was a multicenter cross-sectional/retrospective observational study conducted throughout Spain. The study included patients with nonvalvul...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037051.2017.1313094
更新日期:2017-10-01 00:00:00
abstract::Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population.Materials an...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1658518
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:High normal blood pressure (HNBP), i.e. blood pressure (BP) > or = 130/85 mmHg and <140/90 mmHg, is an important predictor of progression to established hypertension. DESIGN:The purpose of this retrospective study was the evaluation of the predictive value of ambulatory blood pressure monitoring (ABPM) for ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050410021414
更新日期:2004-01-01 00:00:00
abstract::Purpose: To study the differences in attitudes towards hypertension and drug treatment between patients persistent and non-persistent to antihypertensive drug treatment. Materials and methods: Cross-sectional study on patients with hypertension treated at 25 primary healthcare centres in Stockholm, Sweden. Questionnai...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037051.2019.1627858
更新日期:2019-10-01 00:00:00
abstract::To investigate the factors responsible for the morning rise in blood pressure (BP) in obstructive sleep apnea syndrome (OSAS) we examined a group of 253 consecutive snorers or OSAS patients. On the basis of their AHI the patients were classified in four groups. BP was measured on the evening before sleep onset and on ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077598
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2020.1856642
更新日期:2021-01-06 00:00:00
abstract::Patients with severe hypertension with retinoscopic bilateral papilloedema only are not classically regarded as having malignant hypertension (MHT). We have encountered 23 such patients between 1965-1993, whilst over a similar period we have seen 315 patients who fulfilled the conventional criteria for MHT with bilate...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077618
更新日期:1995-11-01 00:00:00
abstract::Physical pain is a major trigger for changes in many homeostatic systems of the body physiology. Our aim was to study the relationship between blood pressure, metabolism and pain perception in subjects with chronic pain symptoms. This was undertaken in a population-based study in primary health care, including subject...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709062085
更新日期:1997-09-01 00:00:00
abstract::Using both in vitro and in vivo techniques, it has repeatedly been shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental hypertension (SHR, Dahl salt-sensitive rat, DOCA-salt rat and renovascular hypertension). EDV has also been found to be impaired in primary, as well as i...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500439362
更新日期:2000-01-01 00:00:00
abstract::Having found that circulating adrenaline (AD) is selectively elevated in stroke-prone spontaneously hypertensive rats (SHRSP) compared with Wistar-Kyoto rats (WKY), we extended the comparison to include other normotensive and hypertensive rat strains. Aortic catheters were implanted in young (5-7 weeks) and old (7-9 m...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101529
更新日期:1994-03-01 00:00:00
abstract::The study explored the relationship between time- and frequency-domain indices of cardiac autonomic control and 24 h blood pressure variability (BPV) in a sample of healthy men and women. Vagally mediated cardiac control was inversely related to 24 h BPV, and measures of cardiac autonomic control were better predictor...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1090721
更新日期:2016-01-01 00:00:00
abstract::The effectiveness of hypertension treatment remains low in many developed countries. The aim of our study was to evaluate the treatment effectiveness in hypertensives treated by general practitioners (GPs) in Poland. Twenty thousand three hundred and five hypertensive patients (mean age 60.1 +/- 12.0 years, 9918 women...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310015458
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to determine if there is an association of different gene polymorphisms of renin-angiotensin system and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St Petersburg population. PATIENTS AND METHODS:We examined 156 patients (the mean age 49+...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370501753182343
更新日期:2001-01-01 00:00:00
abstract::We wanted to investigate whether time to steady state was reached within 2 h of insulin infusion during isoglycemic hyperinsulinemic clamp, comparing the glucose uptake index (M/IG) with Bergman's insulin sensitivity index (Sip). We performed a 2-h oral glucose tolerance test and a 3-h isoglycemic hyperinsulinemic cla...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/080370599439580
更新日期:1999-01-01 00:00:00
abstract::Purpose: Elevated blood pressure induces electrocardiographic changes and is associated with an increase in cardiovascular disease later in life compared to normal blood pressure levels. The purpose of this study was to evaluate the association between normal to high normal blood pressure values (90-139/50-89 mmHg) an...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1673149
更新日期:2020-04-01 00:00:00
abstract::Effective antihypertensive care is not possible without regular and reliable blood pressure measurements. The use of blood pressure home measurement has increased a lot during the last years. Various methods have been used in communication between the patients and physicians. In a randomized study we compared traditio...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037051003718457
更新日期:2010-10-01 00:00:00
abstract::The second Swedish Trial in Old patients with Hypertension (STOP-Hypertension-2) was conducted to compare the effects of 'newer( antihypertensive therapies (angiotensin converting enzyme [ACE] inhibitors and calcium antagonists) and established therapies (beta-blockers and diuretics) on cardiovascular mortality and mo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/blo.9.2.17.20
更新日期:2000-01-01 00:00:00
abstract::In order to study the contribution of the nitric oxide (NO)-pathway to cholinergic vasodilatation in the resistance vessels of the human forearm, we infused acetylcholine (ACh; 0.1 1000 ng/kg/min) or methacholine (MCh; 0.1 A 100 ng/kg/min) in the presence of saline, the NO-scavenger and guanylate cyclase inhibitor met...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609078071
更新日期:1996-11-01 00:00:00
abstract::Blood pressure (BP) and excretory function including lithium clearance were investigated during water-loading and constant infusion of 131I-hippuran and 125I-iothalamate for measurement of renal haemodynamics in 8 untreated essential hypertensives (mean BP +/- SD: 169 +/- 14/107 +/- 6 mmHg) before and after vasodilata...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059309077525
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol. METHODS:Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essent...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/08037051.2013.840421
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The most common ophthalmologic manifestation of hypertension is hypertensive retinopathy. Our study was designed to evaluate the factors that determine retinal vessel caliber in hypertensive subjects. METHODS:During a 6-month period, retinal photographs were taken of participants during a routine yearly che...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2012.645336
更新日期:2012-06-01 00:00:00
abstract::The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2020.1763158
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:This study was to evaluate the relationship of atherosclerotic renal artery stenosis (ARAS) with extracranial carotid arteries atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) in ischemic stroke (IS) patients. METHODS:This study was a prospective cohort analysis of consecutive patients...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2013.765635
更新日期:2013-10-01 00:00:00
abstract::It has been reported that the number of circulating endothelial progenitor cells (EPCs) reflects the endogenous vascular repair ability, with the EPCs pool declining in the presence of cardiovascular risk factors. However, their relationship with hypertension and the effects of anti-hypertensive treatment remain uncle...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037051.2010.535973
更新日期:2011-04-01 00:00:00