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Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: a multicenter, randomized, double-blind study.

Abstract：

INTRODUCTION:The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol. METHODS:Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essential hypertension (systolic blood pressure, SBP ≥ 140 mmHg to ≤ 179 mmHg and diastolic blood pressure, DBP ≥ 90 mmHg to ≤ 109 mmHg after a 2-week run-in placebo period). Patients received nebivolol 5 mg or atenolol 50 mg once daily. At week 3, atenolol could be titrated up to 100 mg qd for non-responders. Additionally, patients not achieving normal blood pressure after 6 weeks could be treated with 25 mg hydrochlorothiazide. Follow-up visits were at 3, 6 and 10 weeks. RESULTS:The final study population of 138 patients (58% men; median age 52.6 years, range 40-67 years) was randomized into two groups of 69 patients each. Baseline characteristics of the two groups were similar. At the screening visit, 69% presented with mild hypertension. Nebivolol modified the mean augmentation index to a lesser extent than atenolol after 10 weeks (mean difference 3.1%, 95% CI 0.55-5.69; p = 0.027). A higher proportion of patients in the atenolol group required a diuretic. Reductions in central aortic pressure and peripheral arterial pressure were similar for both treatment groups. CONCLUSIONS:The study confirms that nebivolol produces a less pronounced impact on augmentation index than atenolol.

journal_name

Blood Press

journal_title

Blood pressure

authors

Redón J,Pascual-Izuel JM,Rodilla E,Vicente A,Oliván J,Bonet J,Torguet JP,Calaforra O,Almirall J

doi

10.3109/08037051.2013.840421

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

181-8

issue

3

eissn

0803-7051

issn

1651-1999

journal_volume

23

pub_type

杂志文章,多中心研究,随机对照试验

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