Effect of antihypertensive treatment on circulating endothelial progenitor cells in patients with mild essential hypertension.

Abstract:

:It has been reported that the number of circulating endothelial progenitor cells (EPCs) reflects the endogenous vascular repair ability, with the EPCs pool declining in the presence of cardiovascular risk factors. However, their relationship with hypertension and the effects of anti-hypertensive treatment remain unclear. We randomized 29 patients with mild essential hypertension to receive barnidipine up to 20 mg or hydrochlorothiazide (HCT) up to 25 mg. Circulating EPCs were isolated from peripheral blood at baseline and after 3 and 6 months of treatment. Mononuclear cells were cultured with endothelial basal medium supplemented with EGM SingleQuots. EPCs were identified by positive double staining for both FITC-labeled Ulex europaeus agglutinin I and Dil-labeled acethylated low-density lipoprotein. After 3 and 6 months of treatment, systolic and diastolic blood pressure (BP) were significantly reduced. No difference was observed between drugs. An increase in the number of EPCs was observed after 3 and 6 months of anti-hypertensive treatment (p < 0.05). Barnidipine significantly increased EPCs after 3 and 6 months of treatment, whereas no effect was observed with HCT. No statistically significant correlation was observed between EPCs and clinical BP values. Our data suggest that antihypertensive treatment may increase the number of EPCs. However, we observed a different effect of barnidipine and HCT on EPCs, suggesting that, beyond its BP lowering effect, barnidipine may elicit additional beneficial properties, related to a healthier vasculature.

journal_name

Blood Press

journal_title

Blood pressure

authors

de Ciuceis C,Pilu A,Rizzoni D,Porteri E,Muiesan ML,Salvetti M,Paini A,Belotti E,Zani F,Boari GE,Rosei CA,Rosei EA

doi

10.3109/08037051.2010.535973

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

77-83

issue

2

eissn

0803-7051

issn

1651-1999

journal_volume

20

pub_type

杂志文章,随机对照试验
  • Blood pressure and metabolic factors in relation to chronic pain.

    abstract::Physical pain is a major trigger for changes in many homeostatic systems of the body physiology. Our aim was to study the relationship between blood pressure, metabolism and pain perception in subjects with chronic pain symptoms. This was undertaken in a population-based study in primary health care, including subject...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059709062085

    authors: Nilsson PM,Kandell-Collén A,Andersson HI

    更新日期:1997-09-01 00:00:00

  • Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and substance P.

    abstract::In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059209077667

    authors: Edvinsson L,Erlinge D,Ekman R,Thulin T

    更新日期:1992-12-01 00:00:00

  • Progress report on the Nordic diltiazem study (NORDIL): an outcome study in hypertensive patients.

    abstract::NORDIL--the Nordic Diltiazem Study (NORDIL)--is a prospective, randomized, open blinded-endpoint (PROBE), multicenter, parallel-group morbidity/mortality outcome study in hypertensive patients designed to compare an intervention strategy based on the calcium antagonist diltiazem with a strategy based on conventional a...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1080/080370599439517

    authors: Hedner T

    更新日期:1999-01-01 00:00:00

  • Beta-adrenergic blocking drugs in the treatment of hypertension.

    abstract::The reduction in blood pressure seen with the use of beta-blocking drugs was an unexpected finding. Initially there was resistance to their use as the reduction of cardiac output and increase in peripheral resistance from beta-blockade was considered an undesirable pharmacological action for a drug in the treatment of...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.1080/080370501753400665

    authors: Prichard BN,Cruickshank JM,Graham BR

    更新日期:2001-01-01 00:00:00

  • Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients.

    abstract::The purpose of the study is to assess the relative impact of lifestyle factors including physical inactivity, cigarette smoking, and alcohol intake on insulin resistance in hypertensive patients. In total, 872 hypertensive patients, of Chinese and Japanese origin, from the Stanford Asia and Pacific Program for Hyperte...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050410004828

    authors: Hwu CM,Hsiao CF,Kuo SW,Wu KD,Ting CT,Quertermous T,Rodriguez B,Chen I,Grove J,Chen PY,Hoo LT

    更新日期:2004-01-01 00:00:00

  • Determinants of hypertension control in a large French population of treated hypertensive subjects.

    abstract::Only a minority of all hypertensives is well controlled in the population. In order to assess the proportion of well controlled hypertensives and the factors associated with hypertension control in France, we designed an observational cross-sectional epidemiological study in a population of 4702 treated adult hyperten...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050500450114

    authors: Roux O,Chapellier M,Czernichow S,Nisse-Durgeat S,Safar ME,Blacher J

    更新日期:2006-01-01 00:00:00

  • Alcohol consumption and blood pressure in recently hospitalised patients.

    abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059709061808

    authors: Howes JB,Ryan J,Fairbrother G,O'Neill K,Howes LG

    更新日期:1997-03-01 00:00:00

  • Comparison of atrial electromechanical coupling interval and P-wave dispersion in non-dipper versus dipper hypertensive subjects.

    abstract:BACKGROUND:The lack of nocturnal BP fall less than 10% of the daytime, called non-dipper hypertension, is associated with increased cardiovascular morbidity and mortality. The aim of our study was to investigate atrial conduction time in patients with non-dipper hypertension using electromechanical coupling interval an...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.532302

    authors: Ermis N,Acikgoz N,Cuglan B,Cansel M,Yagmur J,Tasolar H,Barutcu I,Pekdemir H,Ozdemir R

    更新日期:2011-02-01 00:00:00

  • The effect of clothes on sphygmomanometric and oscillometric blood pressure measurement.

    abstract:AIM:We determined the effect of wearing clothes under the manometer's cuff on blood pressure in manual auscultatory sphygmomanometric and automatic oscillometric blood pressure measurement. METHODS:Two hundred and one subjects were examined with the auscultatory sphygmomanometric and the automatic oscillometric method...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/08037050410016465

    authors: Liebl M,Holzgreve H,Schulz M,Crispin A,Bogner J

    更新日期:2004-01-01 00:00:00

  • Longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease in hypertensive and normotensive adults.

    abstract::The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1763158

    authors: Krajčoviechová A,Wohlfahrt P,Bruthans J,Šulc P,Lánská V,Borghi C,Cífková R

    更新日期:2020-10-01 00:00:00

  • The BBB Study: the effect of intensified antihypertensive treatment on the level of blood pressure, side-effects, morbidity and mortality in "well-treated" hypertensive patients. Behandla Blodtryck Bättre.

    abstract::The BBB study (Swedish for Behandla Blodtryck Bättre or Treat Blood Pressure Better) was a multicenter trial designed to investigate three aspects of antihypertensive treatment: i) Is it possible to lower the diastolic blood pressure further in "well-treated" hypertensive patients through intensified therapy? ii) Can ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/08037059409102265

    authors: Hannson L

    更新日期:1994-07-01 00:00:00

  • Severe hypertension with lone bilateral papilloedema: a variant of malignant hypertension.

    abstract::Patients with severe hypertension with retinoscopic bilateral papilloedema only are not classically regarded as having malignant hypertension (MHT). We have encountered 23 such patients between 1965-1993, whilst over a similar period we have seen 315 patients who fulfilled the conventional criteria for MHT with bilate...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077618

    authors: Lip GY,Beevers M,Dodson PM,Beevers DG

    更新日期:1995-11-01 00:00:00

  • Endothelium-dependent Vasodilation in Hypertension: A Review.

    abstract::Using both in vitro and in vivo techniques, it has repeatedly been shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental hypertension (SHR, Dahl salt-sensitive rat, DOCA-salt rat and renovascular hypertension). EDV has also been found to be impaired in primary, as well as i...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370500439362

    authors: Lind L

    更新日期:2000-01-01 00:00:00

  • Anatomical basis for the fastigial pressor response.

    abstract::Electrical stimulation of rostromedial portion of cerebellar fastigial nucleus elicits integrated cardiovascular effects, which are neurally and humorally mediated. In this study, we sought to demonstrate the anatomical substrates of the fastigial pressor response (FPR) in the rat. The response was electrophysiologica...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050310010912

    authors: Giuditta M,Ruggiero DA,Del Bo A

    更新日期:2003-01-01 00:00:00

  • Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats.

    abstract::To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions. Groups of male Sprague--Dawley rats were fed for 8 weeks with a high-cholesterol diet (4% cholesterol), a ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050510008878

    authors: Minami M,Ishiyama A,Takagi M,Omata M,Atarashi K

    更新日期:2005-01-01 00:00:00

  • Lack of association of the renin-angiotensin system genes polymorphisms and left ventricular hypertrophy in hypertension.

    abstract:OBJECTIVE:The aim of the present study was to determine if there is an association of different gene polymorphisms of renin-angiotensin system and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St Petersburg population. PATIENTS AND METHODS:We examined 156 patients (the mean age 49+...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370501753182343

    authors: Shlyakhto EV,Shwartz EI,Nefedova YB,Zukova AV,Vinnic TA,Conrady AO

    更新日期:2001-01-01 00:00:00

  • Office blood pressure measurements with oscillometric devices in adolescents: a comparison with home blood pressure.

    abstract:PURPOSE:Compare multiple in office BP measurements in adolescents using an oscillometric device with out-of-office blood pressure measurements (home blood pressure monitoring - HBPM). MATERIALS AND METHODS:Office measurements were performed with validated semi-automatic devices twice (3 minutes interval) in two differ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2017.1312279

    authors: Jardim TV,Gaziano TA,Nascente FM,Carneiro CS,Morais P,Roriz V,Mendonça KL,Póvoa TIR,Barroso WKS,Sousa ALL,Jardim PCV

    更新日期:2017-10-01 00:00:00

  • Prevalence of cardiovascular risk factors in Lithuanian middle-aged subjects participating in the primary prevention program, analysis of the period 2009-2012.

    abstract:BACKGROUND:The aim of this study was to assess the prevalence and changes of cardiovascular risk factors in the middle-aged Lithuanian subjects after conducting the primary prevention program. DESIGN AND METHODS:Four cross-sectional investigations of cardiovascular risk factors were conducted in 2009 (n = 9625), 2010 ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/08037051.2014.961744

    authors: Laucevičius A,Rinkūnienė E,Skujaitė A,Petrulionienė Ž,Puronaitė R,Dženkevičiūtė V,Kasiulevičius V,Jatužis D,Ryliškytė L,Šlapikas R

    更新日期:2015-02-01 00:00:00

  • Insulin resistance and sympathetic nervous system activity in hypertensive and normotensive premenopausal women.

    abstract::The aim of the present study was to compare insulin sensitivity and catecholamine responses to insulin in lean, hypertensive (HT) and normotensive (NT) premenopausal women. HT (BP 149 5/99 +/- 2 mmHg, n = 14) and NT (BP 128 +/- 4/81 +/- 2 mmHg, n = 12) were matched for age (46 +/- 1 vs. 47 +/- 1 years) and body mass i...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077609

    authors: Nordby G,Moan A,Kjeldsen SE,Eide IK,Os I

    更新日期:1995-09-01 00:00:00

  • Removing the mask on hypertension (REMAH) study: Design; quality of blood pressure phenotypes and characteristics of the first 490 participants.

    abstract::Purpose: Previous studies that evaluated the prevalence of hypertension in Nigeria were either clinic based, non-standardized or did not include out-of-clinic blood pressure (BP) measurement. Materials and Methods: We selected a rural and an urban community in one state in each of the 6 geopolitical zones of Nigeria. ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2019.1612706

    authors: Nwakile PC,Chori BS,Danladi B,Umar A,Okoye IC,Nwegbu M,Zawaya K,Essien I,Sada K,Ogedengbe J,Aje A,Isiguzo G,Odili AN

    更新日期:2019-08-01 00:00:00

  • Gender differences in the relationship between resting heart rate variability and 24-hour blood pressure variability.

    abstract::The study explored the relationship between time- and frequency-domain indices of cardiac autonomic control and 24 h blood pressure variability (BPV) in a sample of healthy men and women. Vagally mediated cardiac control was inversely related to 24 h BPV, and measures of cardiac autonomic control were better predictor...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2016.1090721

    authors: Thayer JF,Sollers JJ 3rd,Friedman BH,Koenig J

    更新日期:2016-01-01 00:00:00

  • Prevalence of home blood pressure measurement among selected hypertensive patients: results of a multicenter survey from six hospital outpatient hypertension clinics in Italy.

    abstract:AIM:The purpose of this study was to evaluate the prevalence of home blood pressure (BP) measurement, the type of devices and accuracy in a large sample of hypertensive patients referred to hospital outpatient hypertension clinics. METHODS:Eight hundred and fifty-five consecutive treated hypertensive patients who atte...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050500210765

    authors: Cuspidi C,Meani S,Lonati L,Fusi V,Magnaghi G,Garavelli G,Palumbo G,Pini C,Vaccarella A,Parati G,Leonetti G,Zanchetti A,Lombardy Regional Section of the Italian Hypertension Society.

    更新日期:2005-01-01 00:00:00

  • Factors associated with increase in blood pressure and incident hypertension in early midlife: the Hordaland Health Study.

    abstract::Purpose: We aimed to identify sex-specific factors associated with increase in blood pressure (BP) and incident hypertension in early midlife.Materials and methods: 2,008 women and 1,610 men aged 40-43 years were followed for six years in the Hordaland Health Study. Participants taking antihypertensive medication at b...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1762070

    authors: Kringeland E,Tell GS,Midtbø H,Haugsgjerd TR,Igland J,Gerdts E

    更新日期:2020-10-01 00:00:00

  • Vascular stiffness and endothelial dysfunction: Correlations at different levels of blood pressure.

    abstract:UNLABELLED:Resistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance to antihypertensive treatment and cardiovascular complications. Biophysical forces within the arterial wall provide functional regulation of arterial stiffness. Caroti...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2011.617045

    authors: Figueiredo VN,Yugar-Toledo JC,Martins LC,Martins LB,de Faria AP,de Haro Moraes C,Sierra C,Coca A,Moreno H

    更新日期:2012-02-01 00:00:00

  • L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension.

    abstract::Sympathetic nerve activity is augmented by calcium-channel blocker treatment as a result of decreased blood pressure. Dihydropyridine calcium-channel blockers are divided into three different types. The purpose of the present study was to investigate whether treatment effects on hemodynamics, cardiac autonomic nerve a...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/08037051.2012.694200

    authors: Ogura C,Ono K,Miyamoto S,Ikai A,Mitani S,Sugimoto N,Tanaka S,Fujita M

    更新日期:2012-12-01 00:00:00

  • Limitation of physical activity, dyspnea and chest pain prior to and during two years after coronary artery bypass grafting in relation to a history of hypertension.

    abstract:AIM:To describe the limitation of physical activity, the cause of limitation of physical activity and symptoms of dyspnea and chest pain before and 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. METHODS:All patients from western Sweden who underwent CABG between 1988 and...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059709062094

    authors: Herlitz J,Caidahl K,Albertsson P,Karlsson T,Hartford M,Haglid M,Lurje L,Karlson BW,Sjöland H

    更新日期:1997-11-01 00:00:00

  • Blood pressure level and relation to other cardiovascular risk factors in male hypertensive patients without clinical evidence of ischemic heart disease.

    abstract::Arterial hypertension is accompanied by increased morbidity and mortality and constitutes a substantial part of medical care. Antihypertensive intervention reduces the cardiovascular morbidity and mortality. The aims of the study were to evaluate the relationship between cardiovascular risk factors and the blood press...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050050151780

    authors: Larsen CT,Sørum C,Hansen JF,Jensen HA,Rasmussen V

    更新日期:2000-01-01 00:00:00

  • Comparison of the time courses and potencies of the vasodilator effects of nifedipine and felodipine in the human forearm.

    abstract::In a previous study we investigated the differential time courses of the vasodilator effect of various calcium antagonists (CA) in small isolated rat mesenteric arteries (van der Lee et al., Fundam Clin Pharmacol, 1998: 12: 607-12). We concluded that the differences observed could be due to differences in lipophilicit...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037050152669738

    authors: van der Lee R,Pfaffendorf M,Koopmans RP,van Lieshout JJ,van Montfrans GA,van Zwieten PA

    更新日期:2001-01-01 00:00:00

  • The relationship between uric acid and erectile dysfunction in hypertensive subjects.

    abstract:BACKGROUND:Endothelial dysfunction plays a major role in erectile dysfunction (ED). Uric acid (UA) is a marker of endothelial dysfunction. We hypothesized that increased UA levels may be associated with ED and aimed to investigate whether there is a relationship between, UA and ED in hypertensive patients. METHODS:A t...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2014.933032

    authors: Aribas A,Kayrak M,Ulucan S,Keser A,Demir K,Alibasic H,Akilli H,Solak Y,Avci A,Turan Y,Kaya Z,Katlandur H,Kanbay M

    更新日期:2014-12-01 00:00:00

  • Hypertensive nephropathy in children - do we diagnose early enough?

    abstract:BACKGROUND/AIMS:The aim was to evaluate the level of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and retinol binding protein (RBP) in children with primary hypertension and no features of hypertensive nephropathy. METHODS:The study group consisted of 19 children (15 males) aged 14.8 ± 2.1...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2012.666393

    authors: Blumczynski A,Sołtysiak J,Lipkowska K,Silska M,Poprawska A,Musielak A,Zaniew M,Zachwieja J

    更新日期:2012-08-01 00:00:00