Abstract:
:NORDIL--the Nordic Diltiazem Study (NORDIL)--is a prospective, randomized, open blinded-endpoint (PROBE), multicenter, parallel-group morbidity/mortality outcome study in hypertensive patients designed to compare an intervention strategy based on the calcium antagonist diltiazem with a strategy based on conventional antihypertensive drug treatment (diuretics or beta-adrenergic blockers). Patient recruitment was started in Norway and Sweden in September 1992, and ended on December 15, 1996, when 10.896 male and female patients, aged 50-74 years, with essential hypertension had been randomized. In this paper we describe the baseline data of the patient cohort and blood pressures achieved in the two treatment groups during the early part of the study. The patient cohort consists of 5294 males and 5602 females with a mean age of 59.6 and 60.3 years, respectively. Concomitant disorders and risk factors in the cohort are: smoking 22%, ischemic heart disease 3.0%, previous myocardial infarction (MI) 2.0%, previous stroke 1.5%, diabetes mellitus 7.0%, and renal impairment 0.3%. There were no differences between the treatment groups in these respects. The blood pressure treatment goal is a target diastolic blood pressure of < or =90 mmHg or a 10% diastolic blood pressure reduction from the inclusion pressure. In the treatment group randomized to a diltiazem-based treatment strategy, blood pressure was 174/106 mmHg at baseline and 156/90 mmHg after 12 months of follow-up on active treatment. In the group randomized to a conventional treatment strategy, baseline blood pressure at randomization was 173/106 mmHg and 153/90 mmHg after 12 months on active therapy. The NORDIL study will terminate on October 31, 1999 and the final results should be available by mid-2000.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Hedner Tdoi
10.1080/080370599439517subject
Has Abstractpub_date
1999-01-01 00:00:00pages
296-9issue
5-6eissn
0803-7051issn
1651-1999journal_volume
8pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
BLOOD PRESSURE文献大全abstract::Serotonin stimulates phospholipase A(2)(PLA(2)) leading to the production of prostaglandin products, several of which are vasoconstrictors. We hypothesised that the elevated vascular responsiveness to serotonin in deoxycorticosterone acetate (DOCA)-hypertensive rats is due in part to augmented production of vasoconstr...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609062117
更新日期:1996-03-01 00:00:00
abstract::Self-measurement of blood pressure (BP) at home is more common than 10 years ago and encouraged by current guidelines to increase patient adherence to treatment and reach the goal of target BP. The aims of this study are to evaluate the accuracy of home sphygmomanometers and to investigate behavior/knowledge of the sp...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050701758018
更新日期:2008-01-01 00:00:00
abstract:AIM:To describe the limitation of physical activity, the cause of limitation of physical activity and symptoms of dyspnea and chest pain before and 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. METHODS:All patients from western Sweden who underwent CABG between 1988 and...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709062094
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND/AIMS:The aim was to evaluate the level of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and retinol binding protein (RBP) in children with primary hypertension and no features of hypertensive nephropathy. METHODS:The study group consisted of 19 children (15 males) aged 14.8 ± 2.1...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2012.666393
更新日期:2012-08-01 00:00:00
abstract::To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions. Groups of male Sprague--Dawley rats were fed for 8 weeks with a high-cholesterol diet (4% cholesterol), a ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050510008878
更新日期:2005-01-01 00:00:00
abstract::Effective antihypertensive care is not possible without regular and reliable blood pressure measurements. The use of blood pressure home measurement has increased a lot during the last years. Various methods have been used in communication between the patients and physicians. In a randomized study we compared traditio...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037051003718457
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Cerebral white matter lesions (WMLs) are regarded to be subclinical ischemic changes of the cerebral parenchyma. Many previous studies have shown that baseline blood pressure (BP) is one of the most important factors for WMLs, but the relation between exercise BP and WMLs has not been fully evaluated. So, we...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2018.1423544
更新日期:2018-06-01 00:00:00
abstract::The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2020.1763158
更新日期:2020-10-01 00:00:00
abstract::Plasma level of adrenaline has been reported to be elevated in borderline hypertension. However, its role in developing and maintaining hypertension is still not completely understood. This study aimed to estimate the role of plasma adrenaline in developing hypertension. Ten patients with borderline hypertension (BHT)...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077578
更新日期:1995-03-01 00:00:00
abstract::Home blood pressure monitoring (HBPM) is an easy and standardized tool to measure blood pressure (BP) at home, which is recommended by several national and international guidelines to obtain reliable BP values. It is a useful and dependable measure of BP, which can add information to the more common and standardized m...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037051.2015.1070599
更新日期:2015-01-01 00:00:00
abstract::It has previously been documented that patients with obstructive sleep apnoea (OSA) have an abnormal blood pressure (pressor) response to acute hypoxia when awake. The relationship between hypoxic chemosensitivity and 24 h blood pressure in OSA is not known. Twenty-four hour ambulatory BP (ABP) was measured at 15 min ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101521
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate left ventricular (LV) morphology and function in normotensive offspring of subjects with essential hypertension (familial trait - FT), and to determine the association between LV mass and determinants of LV diastolic function and endothelium-dependent (NO-mediated) dilation of the bra...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050701189941
更新日期:2007-01-01 00:00:00
abstract::Atherosclerosis is characterized by hypertrophy of the vascular media, intimal thickening and lipid-containing plaques. Atherosclerosis is a progressive systemic vascular disease which leads to impaired tissue perfusion due to vascular obstruction. In advanced stages it is often complicated by thrombosis. Recent resea...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037059409102274
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.532317
更新日期:2011-04-01 00:00:00
abstract::Plasma atrial natriuretic peptide (ANP), plasma and 24-h urine catecholamines, plasma renin activity (PRA), and serum aldosterone were studied in offspring of hypertensive and normotensive families [n = 82; age 37 +/- 7 years (mean +/- SD)]. Despite higher age, higher blood pressure, and higher urine excretion of cate...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102261
更新日期:1994-07-01 00:00:00
abstract::Arterial hypertension is accompanied by increased morbidity and mortality and constitutes a substantial part of medical care. Antihypertensive intervention reduces the cardiovascular morbidity and mortality. The aims of the study were to evaluate the relationship between cardiovascular risk factors and the blood press...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050050151780
更新日期:2000-01-01 00:00:00
abstract::We compared the effects of amlodipine and verapamil slow release on autonomic responses to a 5-min mental arithmetic test (MST) in patients with mild to moderate hypertension. Twenty subjects received 8 weeks of verapamil slow release 240 mg or amlodipine 10 mg in a double-blind crossover design, both after 4 weeks' p...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/08037050152112096
更新日期:2001-01-01 00:00:00
abstract:AIM:The purpose of this study was to evaluate the prevalence of home blood pressure (BP) measurement, the type of devices and accuracy in a large sample of hypertensive patients referred to hospital outpatient hypertension clinics. METHODS:Eight hundred and fifty-five consecutive treated hypertensive patients who atte...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050500210765
更新日期:2005-01-01 00:00:00
abstract::Gestational hypertension is a recognized risk factor for the development of complications during pregnancy. The present study retrospectively assessed the respective values of blood pressure components derived from conventional and 24-h recordings (ABPM) as predictors of premature delivery in women with gestational hy...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050902836753
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to determine if there is an association of different gene polymorphisms of renin-angiotensin system and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St Petersburg population. PATIENTS AND METHODS:We examined 156 patients (the mean age 49+...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370501753182343
更新日期:2001-01-01 00:00:00
abstract::The Hypertension and Diabetes Screening and Awareness (HYDRA) study is a cross-sectional point-prevalence study performed in September 2001; 45,125 primary care attendees were recruited from a representative nationwide sample of 1912 primary care practices in Germany. Around 42% of all patients presenting in these pra...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310030982
更新日期:2004-01-01 00:00:00
abstract::Low birth weight and high placental weight are associated with increased cardiovascular morbidity and mortality. Children born after hypertensive pregnancies have higher blood pressure than children born after normotensive pregnancies. Hypertension in pregnancy is considered a major risk factor for intrauterine growth...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609078060
更新日期:1996-09-01 00:00:00
abstract::Physical pain is a major trigger for changes in many homeostatic systems of the body physiology. Our aim was to study the relationship between blood pressure, metabolism and pain perception in subjects with chronic pain symptoms. This was undertaken in a population-based study in primary health care, including subject...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709062085
更新日期:1997-09-01 00:00:00
abstract::Whole-body insulin sensitivity has been shown to be impaired in subjects with increased left ventricular relative wall thickness (RWT) and in hypertensive subjects with left ventricular hypertrophy, but the relation between myocardial insulin sensitivity and RWT or left ventricular mass index (LVMI) in normotension is...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/080370501750183354
更新日期:2001-01-01 00:00:00
abstract::In a previous study we investigated the differential time courses of the vasodilator effect of various calcium antagonists (CA) in small isolated rat mesenteric arteries (van der Lee et al., Fundam Clin Pharmacol, 1998: 12: 607-12). We concluded that the differences observed could be due to differences in lipophilicit...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037050152669738
更新日期:2001-01-01 00:00:00
abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.495859
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037050802059092
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Endothelial dysfunction plays a major role in erectile dysfunction (ED). Uric acid (UA) is a marker of endothelial dysfunction. We hypothesized that increased UA levels may be associated with ED and aimed to investigate whether there is a relationship between, UA and ED in hypertensive patients. METHODS:A t...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2014.933032
更新日期:2014-12-01 00:00:00
abstract::Electrical stimulation of rostromedial portion of cerebellar fastigial nucleus elicits integrated cardiovascular effects, which are neurally and humorally mediated. In this study, we sought to demonstrate the anatomical substrates of the fastigial pressor response (FPR) in the rat. The response was electrophysiologica...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310010912
更新日期:2003-01-01 00:00:00
abstract::The balance between matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) plays a key role in the development of hypertension and obesity. We aimed to evaluate the levels of MMP-2 and 9 and TIMP-2 and -1 in obese and non-obese apparent treatment-resistant hypertensive subjects (aTRH) and its association w...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037051.2016.1249336
更新日期:2017-04-01 00:00:00