Arachidonate metabolites and serotonin contraction of femoral arteries from DOCA-salt hypertensive rats.

Abstract:

:Serotonin stimulates phospholipase A(2)(PLA(2)) leading to the production of prostaglandin products, several of which are vasoconstrictors. We hypothesised that the elevated vascular responsiveness to serotonin in deoxycorticosterone acetate (DOCA)-hypertensive rats is due in part to augmented production of vasoconstrictor cyclooxygenase products (e.g. PGF(2)alpha). Denuded helical strips of femoral arteries from DOCA-salt hypertensive rats (SBP 183 +/- 7 mmHg) and normotensive control rats (SBP 115 +/- 2) were used in all experiments. EC(50) values for several agonists were significantly reduced in DOCA arteries compared with controls (in mu mol/L, control vs. DOCA): PGF(2)alpha (0.99 vs. 0.23), PGE(2) (0.72 vs. 0.22), arachidonate (1.52 vs. 0.73), serotonin (0.19 vs. 0.07), noradrenaline (0.029 vs. 0.013), KCl (40.1 vs. 27.0 mmol/L) and AlF(4) (2.3 vs. 1.4 mmol/L). Treatment with indomethacin (14 mu mol/L) inhibited the responses to serotonin in DOCA arteries (EC(50) values 0.07 untreated vs. 0.70) and eliminated the responses to arachidonate but did not affect KCl or AlF(4-)contractions. Cyclooxygenase inhibitors shifted concentration response curves to serotonin in sham and DOCA tissues equally. Thus increased sensitivity to serotonin in DOCA arteries persisted following cyclooxygenase blockade. Therefore, although arachidonate products contribute to the serotonergic contraction in femoral arteries, the augmented response in arteries from DOCA hypertensive rats is not due to increased production of or sensitivity to cyclooxygenase products. Furthermore,arachidonate metabolites do not contribute to the contraction induced by either AlF(4-)or KCl in this preparation.

journal_name

Blood Press

journal_title

Blood pressure

authors

Kanagy NL,Mecca TE,Webb RC

doi

10.3109/08037059609062117

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

113-20

issue

2

eissn

0803-7051

issn

1651-1999

journal_volume

5

pub_type

杂志文章
  • The Bergen Blood Pressure Study: inappropriately low levels of circulating atrial natriuretic peptide in offspring of hypertensive families.

    abstract::Plasma atrial natriuretic peptide (ANP), plasma and 24-h urine catecholamines, plasma renin activity (PRA), and serum aldosterone were studied in offspring of hypertensive and normotensive families [n = 82; age 37 +/- 7 years (mean +/- SD)]. Despite higher age, higher blood pressure, and higher urine excretion of cate...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059409102261

    authors: Mo R,Myking OL,Lund-Johansen P,Omvik P

    更新日期:1994-07-01 00:00:00

  • The effect of percutaneous dilatation of renal arterial stenosis on captopril renography in hypertension.

    abstract:BACKGROUND:The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. METHODS:We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050500339275

    authors: Anfelter P,Granerus G,Stenström H,Eriksson P,Nyström FH

    更新日期:2005-01-01 00:00:00

  • Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and substance P.

    abstract::In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059209077667

    authors: Edvinsson L,Erlinge D,Ekman R,Thulin T

    更新日期:1992-12-01 00:00:00

  • Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients.

    abstract:BACKGROUND:Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.532317

    authors: Yarlioglues M,Kaya MG,Ardic I,Dogdu O,Kasapkara HA,Gunturk E,Akpek M,Kalay N,Dogan A,Ozdogru I,Oguzhan A

    更新日期:2011-04-01 00:00:00

  • The stroke preventive effect in elderly hypertensives cannot fully be explained by the reduction in office blood pressure--insights from the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension).

    abstract:OBJECTIVE:To study whether the cardiovascular preventive effect of antihypertensive therapy can be explained solely by the reduction in office blood pressure, and to what extent the risk of stroke and cardiac events is associated with in-study diastolic blood pressure (DBP) and systolic blood pressure (SBP). DESIGN:Th...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/08037059209077513

    authors: Ekbom T,Dahlöf B,Hansson L,Lindholm LH,Odén A,Scherstén B,Wester PO

    更新日期:1992-10-01 00:00:00

  • The effect of hypertension as a predictor of risk for congestive heart failure patients over a 10-year period in a newly developed country.

    abstract:AIMS:Cardiovascular disease is the leading cause of mortality and morbidity in the western world and has reached epidemic proportions. The incidence of congestive heart failure (CHD) and hypertension is also rising rapidly in many of the affluent Arab nations and cardiovascular diseases continue to be a leading cause o...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050310028462

    authors: Bener A,al Suwaidi J,el-Menyar A,Gehani A

    更新日期:2004-01-01 00:00:00

  • The Bergen Blood Pressure Study: definition of hypertensive and normotensive families based on 27 years' follow-up.

    abstract::The familial aggregation of hypertension is well documented. However, many studies on the familial predisposition have suffered from insufficient knowledge of parental blood pressure (BP). In the present study, the family history is defined according to parental data from two BP surveys conducted almost 30 years apart...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059209077668

    authors: Mo R,Lund-Johansen P,Omvik P

    更新日期:1992-12-01 00:00:00

  • Ascending aortic blood pressure waveform is related to coronary atherosclerosis in hypertensive as well as in normotensive subjects.

    abstract::Ascending aortic blood pressure-derived indices were shown to be related to coronary atherosclerosis. However, no study so far has analyzed the relation between ascending aortic pulsatility and the extent of coronary atherosclerosis in normotensives. Therefore, the aim of the present analysis was to assess the relatio...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050701428125

    authors: Jankowski P,Kawecka-Jaszcz K,Czarnecka D

    更新日期:2007-01-01 00:00:00

  • Effects of low sodium diet and unilateral nephrectomy on the development of carbohydrate-induced hypertension.

    abstract::Since there appear to be important interactions between mechanisms of salt-sensitive and carbohydrate-sensitive hypertension, the goal of this study was to evaluate the effects of greatly reducing dietary salt intake and removal of one kidney (to increase salt sensitivity) on the hemodynamic and metabolic responses to...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077589

    authors: Donnelly R,Ho H,Reaven GM

    更新日期:1995-05-01 00:00:00

  • Interaction of the C-344T polymorphism of CYP11b2 gene with body mass index and waist circumference affecting diastolic blood pressure in Chinese Mongolian population.

    abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.495859

    authors: Pan X,Liu Y,Zhang Y,Zhang X,Xu Q,Tong W

    更新日期:2010-12-01 00:00:00

  • Life style habits, biochemical factors and their interaction in the prediction of incident hypertension during 21-year follow-up.

    abstract:BACKGROUND:Hypertension is a global health threat and major cardiovascular risk. Various risk-prediction models for incident hypertension have been developed but not many of them have studied the risk-predictive value of life style factors in combination with cardiovascular biomarkers during long-term period of over 10...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2018.1540923

    authors: Terho A,Bloigu R,Bloigu A,Niemelä O,Tulppo M,Kesäniemi YA,Ukkola O

    更新日期:2019-02-01 00:00:00

  • Association of retinal microvascular caliber with blood pressure levels.

    abstract:BACKGROUND:The most common ophthalmologic manifestation of hypertension is hypertensive retinopathy. Our study was designed to evaluate the factors that determine retinal vessel caliber in hypertensive subjects. METHODS:During a 6-month period, retinal photographs were taken of participants during a routine yearly che...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2012.645336

    authors: Gepstein R,Rosman Y,Rechtman E,Koren-Morag N,Segev S,Assia E,Grossman E

    更新日期:2012-06-01 00:00:00

  • Determinants of hypertension control in a large French population of treated hypertensive subjects.

    abstract::Only a minority of all hypertensives is well controlled in the population. In order to assess the proportion of well controlled hypertensives and the factors associated with hypertension control in France, we designed an observational cross-sectional epidemiological study in a population of 4702 treated adult hyperten...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050500450114

    authors: Roux O,Chapellier M,Czernichow S,Nisse-Durgeat S,Safar ME,Blacher J

    更新日期:2006-01-01 00:00:00

  • Crosstalk between obesity and MMP-9 in cardiac remodelling -a cross-sectional study in apparent treatment-resistant hypertension.

    abstract::The balance between matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) plays a key role in the development of hypertension and obesity. We aimed to evaluate the levels of MMP-2 and 9 and TIMP-2 and -1 in obese and non-obese apparent treatment-resistant hypertensive subjects (aTRH) and its association w...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037051.2016.1249336

    authors: Ritter AM,de Faria AP,Barbaro N,Sabbatini AR,Corrêa NB,Brunelli V,Amorim R,Modolo R,Moreno H

    更新日期:2017-04-01 00:00:00

  • Development of insulin resistance and elevated blood pressure during therapy with cyclosporine A.

    abstract:OBJECTIVES:Essential hypertension and insulin resistance frequently coexist; cyclosporine A (CsA) is known to induce hypertension which has been used as a model for essential hypertension. The present study aimed to evaluate whether elevated blood pressure and insulin resistance coexist during CsA therapy to prove the ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.3109/08037059709086440

    authors: Kutkuhn B,Hollenbeck M,Heering P,Koch M,Voiculescu A,Reinhard T,Grabensee B

    更新日期:1997-01-01 00:00:00

  • Beta-adrenergic blocking drugs in the treatment of hypertension.

    abstract::The reduction in blood pressure seen with the use of beta-blocking drugs was an unexpected finding. Initially there was resistance to their use as the reduction of cardiac output and increase in peripheral resistance from beta-blockade was considered an undesirable pharmacological action for a drug in the treatment of...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.1080/080370501753400665

    authors: Prichard BN,Cruickshank JM,Graham BR

    更新日期:2001-01-01 00:00:00

  • Effects of aortic ligation on the renin angiotensin system in hydronephrotic mice.

    abstract::A model of aortic ligation in mice with a hydronephrotic kidney (absence of macula densa) was used to determine the effects of aortic ligation on the renal renin-angiotensin system (RAS). Blood pressure increased from 83 +/- 2 to 133 +/- 8 mmHg within 7 days after aortic ligation (p < 0.01). Aortic ligation increased ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370599438301

    authors: Zhang DY,Morgan TO

    更新日期:1999-01-01 00:00:00

  • Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: a multicenter, randomized, double-blind study.

    abstract:INTRODUCTION:The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol. METHODS:Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essent...

    journal_title:Blood pressure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3109/08037051.2013.840421

    authors: Redón J,Pascual-Izuel JM,Rodilla E,Vicente A,Oliván J,Bonet J,Torguet JP,Calaforra O,Almirall J

    更新日期:2014-06-01 00:00:00

  • Home blood pressure measurements: advantages and disadvantages compared to office and ambulatory monitoring.

    abstract::Home blood pressure monitoring (HBPM) is an easy and standardized tool to measure blood pressure (BP) at home, which is recommended by several national and international guidelines to obtain reliable BP values. It is a useful and dependable measure of BP, which can add information to the more common and standardized m...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.3109/08037051.2015.1070599

    authors: Bonafini S,Fava C

    更新日期:2015-01-01 00:00:00

  • Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk.

    abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1856642

    authors: Olsen E,Holzhauer B,Julius S,Kjeldsen SE,Larstorp ACK,Mancia G,Mehlum MH,Mo R,Rostrup M,Søraas CL,Zappe D,Weber MA

    更新日期:2021-01-06 00:00:00

  • L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension.

    abstract::Sympathetic nerve activity is augmented by calcium-channel blocker treatment as a result of decreased blood pressure. Dihydropyridine calcium-channel blockers are divided into three different types. The purpose of the present study was to investigate whether treatment effects on hemodynamics, cardiac autonomic nerve a...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/08037051.2012.694200

    authors: Ogura C,Ono K,Miyamoto S,Ikai A,Mitani S,Sugimoto N,Tanaka S,Fujita M

    更新日期:2012-12-01 00:00:00

  • Hormone-secreting large adrenal ganglioneuroma in an adult patient: a case report and review of literature.

    abstract::BACKGROUND. Ganglioneuromas (GNs) are neural crest cell-derived tumors and rarely occur in the adrenal gland. They are usually asymptomatic and hormonally silent. The majority of cases are detected incidentally during work-up for unrelated conditions. Hormone-secreting pure adrenal GNs in adults are extremely rare. To...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.3109/08037051.2013.796103

    authors: Erem C,Fidan M,Civan N,Cobanoglu U,Kangul F,Nuhoglu I,Alhan E

    更新日期:2014-02-01 00:00:00

  • A comparison of blood pressure control in a hypertension hospital clinic between 1997 and 2000.

    abstract:AIMS:(1) To evaluate the prevalence of clinic blood pressure (BP) control in a large sample of treated hypertensives followed in our hypertension clinic during the year 2000, and to compare it with our 1997 data. (2) To investigate the prevalence of left ventricular hypertrophy (LVH) according to different levels of BP...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050213762

    authors: Cuspidi C,Michev I,Fusi V,Severgnini B,Sala C,Meani S,Corti C,Valerio C,Magrini F,Zanchetti A

    更新日期:2002-01-01 00:00:00

  • Self-measurement of blood pressure at home: is it reliable?

    abstract::Self-measurement of blood pressure (BP) at home is more common than 10 years ago and encouraged by current guidelines to increase patient adherence to treatment and reach the goal of target BP. The aims of this study are to evaluate the accuracy of home sphygmomanometers and to investigate behavior/knowledge of the sp...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050701758018

    authors: Dilek M,Adibelli Z,Aydogdu T,Koksal AR,Cakar B,Akpolat T

    更新日期:2008-01-01 00:00:00

  • The acute effect of continuous positive airway pressure titration on blood pressure in awake overweight/obese patients with obstructive sleep apnoea.

    abstract:OBJECTIVES:Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular syst...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037051.2018.1443391

    authors: Ratneswaran C,Pengo MF,Xiao S,Luo Y,Rossi GP,Polkey MI,Moxham J,Steier J

    更新日期:2018-08-01 00:00:00

  • Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension.

    abstract::Low compliance to therapeutic regimens can have serious impact on patient health. A variety of technologies such as tablet dispensers and reminders has been developed to improve compliance. The aim of this study was to assess the acceptance of patients and physicians with regard to the functions and usefulness of a re...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037050903289598

    authors: Christensen A,Christrup LL,Fabricius PE,Chrostowska M,Wronka M,Narkiewicz K,Hansen EH

    更新日期:2009-01-01 00:00:00

  • Increased left ventricular mass and diastolic dysfunction are associated with endothelial dysfunction in normotensive offspring of subjects with essential hypertension.

    abstract:OBJECTIVES:We aimed to investigate left ventricular (LV) morphology and function in normotensive offspring of subjects with essential hypertension (familial trait - FT), and to determine the association between LV mass and determinants of LV diastolic function and endothelium-dependent (NO-mediated) dilation of the bra...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050701189941

    authors: Zizek B,Poredos P

    更新日期:2007-01-01 00:00:00

  • Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes.

    abstract::There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure. Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetyl...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.481808

    authors: Biala A,Tauriainen E,Siltanen A,Shi J,Merasto S,Louhelainen M,Martonen E,Finckenberg P,Muller DN,Mervaala E

    更新日期:2010-06-01 00:00:00

  • Effect of antihypertensive treatment on circulating endothelial progenitor cells in patients with mild essential hypertension.

    abstract::It has been reported that the number of circulating endothelial progenitor cells (EPCs) reflects the endogenous vascular repair ability, with the EPCs pool declining in the presence of cardiovascular risk factors. However, their relationship with hypertension and the effects of anti-hypertensive treatment remain uncle...

    journal_title:Blood pressure

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/08037051.2010.535973

    authors: de Ciuceis C,Pilu A,Rizzoni D,Porteri E,Muiesan ML,Salvetti M,Paini A,Belotti E,Zani F,Boari GE,Rosei CA,Rosei EA

    更新日期:2011-04-01 00:00:00

  • The BBB Study: the effect of intensified antihypertensive treatment on the level of blood pressure, side-effects, morbidity and mortality in "well-treated" hypertensive patients. Behandla Blodtryck Bättre.

    abstract::The BBB study (Swedish for Behandla Blodtryck Bättre or Treat Blood Pressure Better) was a multicenter trial designed to investigate three aspects of antihypertensive treatment: i) Is it possible to lower the diastolic blood pressure further in "well-treated" hypertensive patients through intensified therapy? ii) Can ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/08037059409102265

    authors: Hannson L

    更新日期:1994-07-01 00:00:00