Abstract:
PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing the risk of CV events in patients who participated in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial and compared the hypertensive patients with type 2 diabetes mellitus with all high-risk hypertensive patients. MATERIALS AND METHODS:Patients were divided into 4 groups according to the proportion of on-treatment visits before the occurrence of an event (<25% to ≥75%) in which BP was reduced to <140/90 or <130/80 mmHg. Patients with diabetes mellitus (n = 5250) were compared with the entire VALUE population with high CV risk (n = 15,245). RESULTS:After adjustments for baseline differences between groups, a reduction in the proportion of visits in which BP was reduced to <140/90 mmHg, but not to <130/80 mmHg, was accompanied by a progressive increase in the risk of CV morbidity and mortality as well as stroke, myocardial infarction and heart failure in both diabetes mellitus and in all high-risk patients. Target BP <130/80 mmHg reduced stroke risk in the main population but not in the diabetes mellitus patients. Patients with diabetes mellitus had higher event rates for the primary cardiac endpoint and all-cause mortality driven by a higher rate of heart failure. CONCLUSION:In the high-risk hypertensive patients of the VALUE trial achieving more frequently BP <140/90 mmHg, but not <130/80 mmHg, showed principally the same protective effect on overall and cause-specific cardiovascular outcomes in patients with diabetes mellitus and in the general high-risk hypertensive population.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Olsen E,Holzhauer B,Julius S,Kjeldsen SE,Larstorp ACK,Mancia G,Mehlum MH,Mo R,Rostrup M,Søraas CL,Zappe D,Weber MAdoi
10.1080/08037051.2020.1856642subject
Has Abstractpub_date
2021-01-06 00:00:00pages
1-8eissn
0803-7051issn
1651-1999pub_type
杂志文章相关文献
BLOOD PRESSURE文献大全abstract::The study explored the relationship between time- and frequency-domain indices of cardiac autonomic control and 24 h blood pressure variability (BPV) in a sample of healthy men and women. Vagally mediated cardiac control was inversely related to 24 h BPV, and measures of cardiac autonomic control were better predictor...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1090721
更新日期:2016-01-01 00:00:00
abstract:AIM:To describe the limitation of physical activity, the cause of limitation of physical activity and symptoms of dyspnea and chest pain before and 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. METHODS:All patients from western Sweden who underwent CABG between 1988 and...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709062094
更新日期:1997-11-01 00:00:00
abstract::Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or withou...
journal_title:Blood pressure
pub_type: 杂志文章,meta分析
doi:10.1080/08037051.2019.1644155
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function. METHODS:Fifteen young (26 +/- 4 years) healthy normotensive (115 +/- 8/71 +/- 6 mmHg) subjects with a FHH, 31 matched healt...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370502320779485
更新日期:2002-01-01 00:00:00
abstract::Elevated intracellular free calcium (Ca2+) has been proposed as a mechanism of alcohol-induced hypertension from animal experimental studies, but this has not been confirmed in man. In the present study, intraplatelet Ca2+ concentration (plt.[Ca2+]i) was measured in 83 middle-aged men, and the associations between alc...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077576
更新日期:1995-03-01 00:00:00
abstract::Gestational hypertension is a recognized risk factor for the development of complications during pregnancy. The present study retrospectively assessed the respective values of blood pressure components derived from conventional and 24-h recordings (ABPM) as predictors of premature delivery in women with gestational hy...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050902836753
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:There is an association between exercise systolic blood pressure (SBP) and cardiovascular disease and mortality. The aim of this study was to investigate this association, with 35 years of follow-up. METHODS:Through 1972-75, 2014 healthy, middle-aged men underwent thorough medical examination and a bicycle e...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2017.1291276
更新日期:2017-08-01 00:00:00
abstract::Neurohormonal changes in congestive heart failure (CHF) include an enhanced peripheral sympathetic nerve activity which results in increased release of noradrenaline, neuropeptide Y and ATP. To examine if such changes in CHF would modulate peripheral pre- and postsynaptic receptors of ATP and its degradation product a...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500453500
更新日期:2000-01-01 00:00:00
abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709061808
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVES:Essential hypertension and insulin resistance frequently coexist; cyclosporine A (CsA) is known to induce hypertension which has been used as a model for essential hypertension. The present study aimed to evaluate whether elevated blood pressure and insulin resistance coexist during CsA therapy to prove the ...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.3109/08037059709086440
更新日期:1997-01-01 00:00:00
abstract::This 1-year, dose-titration, General Practitioner (GP) study compared efficacy, tolerability and safety of oral temocapril (10-40 mg once daily) with atenolol (25-100 mg once daily) in mild to moderate adult hypertensives (diastolic blood pressure (DBP) 95-114 mmHg). A 12-week dose-titration period, randomized 3:1 tem...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/08037059709062074
更新日期:1997-07-01 00:00:00
abstract::In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209077667
更新日期:1992-12-01 00:00:00
abstract::Medullipin I (Med I) is a vasodepressor prohormone which is continuously elaborated into the renal venous effluent (RVE) of isolated rat kidneys perfused under high pressure. We have improved the yield of Med I by substituting saline for the albumin perfusate previously reported; and considerably improved refinement b...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102295
更新日期:1994-11-01 00:00:00
abstract::In order to study the contribution of the nitric oxide (NO)-pathway to cholinergic vasodilatation in the resistance vessels of the human forearm, we infused acetylcholine (ACh; 0.1 1000 ng/kg/min) or methacholine (MCh; 0.1 A 100 ng/kg/min) in the presence of saline, the NO-scavenger and guanylate cyclase inhibitor met...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609078071
更新日期:1996-11-01 00:00:00
abstract::Serum uric acid (SUA) but also hemorheological parameters such as hematocrit (Hct) and whole blood viscosity (WBV) are markers of cardiovascular risk. Increased blood cell volume is one of the known causes of hyperuricemia. We therefore aimed to investigate the relationship between SUA and hemorheology in untreated bo...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2020.1763158
更新日期:2020-10-01 00:00:00
abstract::BACKGROUND AND AIM. The ratio of deceleration time to early mitral wave velocity (mitral deceleration index, MDI) has been recently shown to predict cardiovascular events more precisely than deceleration time alone in human hypertension. Data, however, about the relationship of this parameter with cardiac structure ar...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2011.553926
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:There are controversial results regarding the endothelial function in patients with white coat hypertension (WCH). The aim of this study was to assess endothelial function measuring nitric oxide (NO) and C-reactive protein (CRP) level in WCH and to compare those with essential hypertension (EH) and healthy s...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2011.649541
更新日期:2012-10-01 00:00:00
abstract::The second Swedish Trial in Old patients with Hypertension (STOP-Hypertension-2) was conducted to compare the effects of 'newer( antihypertensive therapies (angiotensin converting enzyme [ACE] inhibitors and calcium antagonists) and established therapies (beta-blockers and diuretics) on cardiovascular mortality and mo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/blo.9.2.17.20
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.532317
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037050802059092
更新日期:2008-01-01 00:00:00
abstract::The HEART project was conducted in general practice to determine whether lifestyle strategies, aimed at increasing physical activity and dietary modification, can be substituted for drug therapy in patients who have been well controlled on antihypertensive medication. In addition to blood pressure (BP) and risk factor...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/080370500448650
更新日期:2000-01-01 00:00:00
abstract::Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.1080/08037050802677695
更新日期:2009-01-01 00:00:00
abstract::Having found that circulating adrenaline (AD) is selectively elevated in stroke-prone spontaneously hypertensive rats (SHRSP) compared with Wistar-Kyoto rats (WKY), we extended the comparison to include other normotensive and hypertensive rat strains. Aortic catheters were implanted in young (5-7 weeks) and old (7-9 m...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101529
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The lack of nocturnal BP fall less than 10% of the daytime, called non-dipper hypertension, is associated with increased cardiovascular morbidity and mortality. The aim of our study was to investigate atrial conduction time in patients with non-dipper hypertension using electromechanical coupling interval an...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.532302
更新日期:2011-02-01 00:00:00
abstract::An estimate of arterial compliance--the stroke volume/pulse pressure ratio (SV/PP)--was studied in 801 participants in the Tecumseh Blood Pressure Study, a population-based ongoing cardiovascular, epidemiological investigation. The subjects were normal young adults (mean age 30 +/- 5.6 years) and 373 were females. Car...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209065121
更新日期:1992-05-01 00:00:00
abstract::Blood pressure (BP) and excretory function including lithium clearance were investigated during water-loading and constant infusion of 131I-hippuran and 125I-iothalamate for measurement of renal haemodynamics in 8 untreated essential hypertensives (mean BP +/- SD: 169 +/- 14/107 +/- 6 mmHg) before and after vasodilata...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059309077525
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Orthostatic hypotension (OH) is common amongst the older population and is associated with morbidity and mortality. We sought to investigate predictors of OH to assist the clinician in identifying patients at risk. METHODS AND RESULTS:Database of 2696 patients attending a transient ischaemic attack (TIA) cl...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2012.732780
更新日期:2013-04-01 00:00:00
abstract:AIMS:(1) To evaluate the prevalence of clinic blood pressure (BP) control in a large sample of treated hypertensives followed in our hypertension clinic during the year 2000, and to compare it with our 1997 data. (2) To investigate the prevalence of left ventricular hypertrophy (LVH) according to different levels of BP...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050213762
更新日期:2002-01-01 00:00:00
abstract::To investigate further the relationship between atherosclerotic vascular disease and blood pressure, and the phenomenon of white coat hypertension, we performed a cross-sectional study of patients referred for carotid Doppler scanning, to determine the relationship between ambulatory blood pressure monitoring (ABPM) a...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370599439652
更新日期:1999-01-01 00:00:00