Life style habits, biochemical factors and their interaction in the prediction of incident hypertension during 21-year follow-up.


BACKGROUND:Hypertension is a global health threat and major cardiovascular risk. Various risk-prediction models for incident hypertension have been developed but not many of them have studied the risk-predictive value of life style factors in combination with cardiovascular biomarkers during long-term period of over 10 years. METHODS:We examined differences in several classical variables for 299 subjects in OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort in subjects with no or new hypertension during a follow-up period of 21 years. Effect of both various life style habits and biomarkers were investigated. RESULTS:Baseline blood pressure, being overweight and smoking actively were independent predictors of new hypertension in majority of multivariate models during long-term follow-up of 21 years in subjects without previous hypertension. Increased high-sensitive C-reactive protein (hsCRP) level (> 3 mg/L) was the strongest predictor of incident hypertension in univariate model. Subjects with two or all three of main risk factors (being overweight, smoking actively and having high hsCRP) had 4-fold risk for incident hypertension. CONCLUSIONS:Smoking, overweight and increased hsCRP level had risk-predictive value in incident hypertension prediction during long-term follow-up of 21 years. Assessment and measurement of these parameters could be used in help of detecting high risk subjects and primary prevention of hypertension very early on. In addition, the study shows that blood pressure at the middle-age should be followed and treated intensively to prevent hypertension in the older age. KEY MESSAGES:Baseline blood pressure, being overweight and smoking actively are independent predictors of new hypertension during a long-term follow-up of 21 years. Having two or all three risk factors (smoking actively, body mass index over 25 kg/m2, high-sensitive C-reactive protein (hsCRP) level over 3 mg/L) indicates a 4-fold risk for incident hypertension within 21-year follow-up.


Blood Press


Blood pressure


Terho A,Bloigu R,Bloigu A,Niemelä O,Tulppo M,Kesäniemi YA,Ukkola O




Has Abstract


2019-02-01 00:00:00












  • Hypertension in pregnancy and size at birth.

    abstract::Low birth weight and high placental weight are associated with increased cardiovascular morbidity and mortality. Children born after hypertensive pregnancies have higher blood pressure than children born after normotensive pregnancies. Hypertension in pregnancy is considered a major risk factor for intrauterine growth...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Himmelmann K,Himmelmann A,Niklasson A,Svensson A

    更新日期:1996-09-01 00:00:00

  • Comparison of temocapril and atenolol in the long-term treatment of mild to moderate essential hypertension.

    abstract::This 1-year, dose-titration, General Practitioner (GP) study compared efficacy, tolerability and safety of oral temocapril (10-40 mg once daily) with atenolol (25-100 mg once daily) in mild to moderate adult hypertensives (diastolic blood pressure (DBP) 95-114 mmHg). A 12-week dose-titration period, randomized 3:1 tem...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Sierakowski B,Püchler K,Witte PU,Renneisen K,Delius W

    更新日期:1997-07-01 00:00:00

  • Plasma adrenaline modulates alpha 1-adrenoceptor mediated pressor responses and the baroreflex control in patients with borderline hypertension.

    abstract::Plasma level of adrenaline has been reported to be elevated in borderline hypertension. However, its role in developing and maintaining hypertension is still not completely understood. This study aimed to estimate the role of plasma adrenaline in developing hypertension. Ten patients with borderline hypertension (BHT)...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Minatoguchi S,Ito H,Ishimura K,Suzuki T,Tonai N,Mori M,Hirakawa S,Fujiwara H

    更新日期:1995-03-01 00:00:00

  • Clinical, anthropometric, metabolic and insulin profile of men with fast annual growth rates of benign prostatic hyperplasia.

    abstract::The purpose of this study was to test the hypothesis of a causal relationship between high insulin levels and the development of benign prostatic hyperplasia (BPH) and to determine the clinical, anthropometric, metabolic and insulin profile in men with fast-growing BPH compared with men with slow-growing BPH. The pres...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Hammarsten J,Högstedt B

    更新日期:1999-01-01 00:00:00

  • Progressive effects of valsartan compared with amlodipine in prevention of diabetes according to categories of diabetogenic risk in hypertensive patients: the VALUE trial.

    abstract::We have previously shown that the angiotensin receptor blocker valsartan is associated with a lower incidence of new-onset type 2 diabetes than that with the calcium-channel antagonist amlodipine in the treatment of hypertensive patients at high cardiovascular risk. We have now investigated the benefits of valsartan v...

    journal_title:Blood pressure

    pub_type: 杂志文章,随机对照试验


    authors: Kjeldsen SE,McInnes GT,Mancia G,Hua TA,Julius S,Weber MA,Coca A,Girerd X,Jamerson K,Larochelle P,Macdonald T,Schmieder RE,Anthony Schork M,Viskoper R,Widimsky J,Zanchetti A

    更新日期:2008-01-01 00:00:00

  • Intraplatelet free calcium concentrations and alcohol-related blood pressure elevation in a middle-aged male population.

    abstract::Elevated intracellular free calcium (Ca2+) has been proposed as a mechanism of alcohol-induced hypertension from animal experimental studies, but this has not been confirmed in man. In the present study, intraplatelet Ca2+ concentration (plt.[Ca2+]i) was measured in 83 middle-aged men, and the associations between alc...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Ikai E,Ishizaki M,Tsuritani I,Ishida M,Noborisaka Y,Yamada Y

    更新日期:1995-03-01 00:00:00

  • Ambulatory monitoring predicts development of drug-treated hypertension in subjects with high normal blood pressure.

    abstract:BACKGROUND:High normal blood pressure (HNBP), i.e. blood pressure (BP) > or = 130/85 mmHg and <140/90 mmHg, is an important predictor of progression to established hypertension. DESIGN:The purpose of this retrospective study was the evaluation of the predictive value of ambulatory blood pressure monitoring (ABPM) for ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Pannarale G,Gaudio C,Mirabelli F,Monti F,Franchitto S,Di Michele S,Puddu PE,Fedele F

    更新日期:2004-01-01 00:00:00

  • Interaction of the C-344T polymorphism of CYP11b2 gene with body mass index and waist circumference affecting diastolic blood pressure in Chinese Mongolian population.

    abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Pan X,Liu Y,Zhang Y,Zhang X,Xu Q,Tong W

    更新日期:2010-12-01 00:00:00

  • Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension.

    abstract::Prehypertension is associated with increased cardiovascular events. While the "tracking phenomenon" is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP tre...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Hering D,Kara T,Kucharska W,Somers VK,Narkiewicz K

    更新日期:2016-06-01 00:00:00

  • Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females.

    abstract::We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Suwazono Y,Kobayashi E,Uetani M,Miura K,Morikawa Y,Ishizaki M,Kido T,Nakagawa H,Nogawa K

    更新日期:2006-01-01 00:00:00

  • Less adrenergic response to mental task during verapamil compared to amlodipine treatment in hypertensive subjects.

    abstract::We compared the effects of amlodipine and verapamil slow release on autonomic responses to a 5-min mental arithmetic test (MST) in patients with mild to moderate hypertension. Twenty subjects received 8 weeks of verapamil slow release 240 mg or amlodipine 10 mg in a double-blind crossover design, both after 4 weeks' p...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sevre K,Lefrandt JD,Eide I,Smit AJ,Rostrup M

    更新日期:2001-01-01 00:00:00

  • Unattended versus two attended, ambulatory and central blood pressure measurements in hypertensive patients with and without diabetes.

    abstract:OBJECTIVE:To compare unattended blood pressure (BP) with two attended BP, with 24-h ambulatory (ABPM) and central BP measurements in hypertensive patients with (DMs) and without diabetes (HTs). METHODS:In the same hypertension clinic we evaluate 129 consecutive HTs (56% female, 59 + 16 yrs) and 91 DMs (62% female, 64 ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Polonia J,Baptista C,Silva J,Barbosa L

    更新日期:2019-04-01 00:00:00

  • Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension.

    abstract::Low compliance to therapeutic regimens can have serious impact on patient health. A variety of technologies such as tablet dispensers and reminders has been developed to improve compliance. The aim of this study was to assess the acceptance of patients and physicians with regard to the functions and usefulness of a re...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Christensen A,Christrup LL,Fabricius PE,Chrostowska M,Wronka M,Narkiewicz K,Hansen EH

    更新日期:2009-01-01 00:00:00

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    abstract::BACKGROUND AND AIM. The ratio of deceleration time to early mitral wave velocity (mitral deceleration index, MDI) has been recently shown to predict cardiovascular events more precisely than deceleration time alone in human hypertension. Data, however, about the relationship of this parameter with cardiac structure ar...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Cuspidi C,Negri F,Sala C,Mancia G

    更新日期:2011-08-01 00:00:00

  • Comparison of atrial electromechanical coupling interval and P-wave dispersion in non-dipper versus dipper hypertensive subjects.

    abstract:BACKGROUND:The lack of nocturnal BP fall less than 10% of the daytime, called non-dipper hypertension, is associated with increased cardiovascular morbidity and mortality. The aim of our study was to investigate atrial conduction time in patients with non-dipper hypertension using electromechanical coupling interval an...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Ermis N,Acikgoz N,Cuglan B,Cansel M,Yagmur J,Tasolar H,Barutcu I,Pekdemir H,Ozdemir R

    更新日期:2011-02-01 00:00:00

  • Exercise systolic blood pressure at moderate workload predicts cardiovascular disease and mortality through 35 years of follow-up in healthy, middle-aged men.

    abstract:OBJECTIVE:There is an association between exercise systolic blood pressure (SBP) and cardiovascular disease and mortality. The aim of this study was to investigate this association, with 35 years of follow-up. METHODS:Through 1972-75, 2014 healthy, middle-aged men underwent thorough medical examination and a bicycle e...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Mariampillai JE,Engeseth K,Kjeldsen SE,Grundvold I,Liestøl K,Erikssen G,Erikssen J,Bodegard J,Skretteberg PT

    更新日期:2017-08-01 00:00:00

  • Blood pressure control in anticoagulated patients with hypertension and atrial fibrillation.

    abstract:OBJECTIVE:To determine the clinical profile and blood pressure (BP) control rates of anticoagulated patients with hypertension and atrial fibrillation (AF). METHODS:The PAULA study was a multicenter cross-sectional/retrospective observational study conducted throughout Spain. The study included patients with nonvalvul...

    journal_title:Blood pressure

    pub_type: 杂志文章,多中心研究


    authors: Barrios V,Escobar C,Prieto Valiente L,Lobos JM,Vargas-Ortega D,Polo J,Marin Montañés N

    更新日期:2017-10-01 00:00:00

  • Hormone-secreting large adrenal ganglioneuroma in an adult patient: a case report and review of literature.

    abstract::BACKGROUND. Ganglioneuromas (GNs) are neural crest cell-derived tumors and rarely occur in the adrenal gland. They are usually asymptomatic and hormonally silent. The majority of cases are detected incidentally during work-up for unrelated conditions. Hormone-secreting pure adrenal GNs in adults are extremely rare. To...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审


    authors: Erem C,Fidan M,Civan N,Cobanoglu U,Kangul F,Nuhoglu I,Alhan E

    更新日期:2014-02-01 00:00:00

  • Prevalence of home blood pressure measurement among selected hypertensive patients: results of a multicenter survey from six hospital outpatient hypertension clinics in Italy.

    abstract:AIM:The purpose of this study was to evaluate the prevalence of home blood pressure (BP) measurement, the type of devices and accuracy in a large sample of hypertensive patients referred to hospital outpatient hypertension clinics. METHODS:Eight hundred and fifty-five consecutive treated hypertensive patients who atte...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Cuspidi C,Meani S,Lonati L,Fusi V,Magnaghi G,Garavelli G,Palumbo G,Pini C,Vaccarella A,Parati G,Leonetti G,Zanchetti A,Lombardy Regional Section of the Italian Hypertension Society.

    更新日期:2005-01-01 00:00:00

  • The effect of percutaneous dilatation of renal arterial stenosis on captopril renography in hypertension.

    abstract:BACKGROUND:The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. METHODS:We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Anfelter P,Granerus G,Stenström H,Eriksson P,Nyström FH

    更新日期:2005-01-01 00:00:00

  • Metabolic syndrome and cardiometabolic risk: an update.

    abstract::Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审


    authors: Grassi G,Seravalle G,Quarti-Trevano F,Dell'Oro R,Bombelli M,Mancia G

    更新日期:2009-01-01 00:00:00

  • Influence of atorvastatin on blood pressure control in treated hypertensive, normolipemic patients - An open, pilot study.

    abstract:AIMS:The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, nor...

    journal_title:Blood pressure

    pub_type: 杂志文章,随机对照试验


    authors: Kuklinska AM,Mroczko B,Musial WJ,Sawicki R,Kozieradzka A,Usowicz-Szarynska M,Kaminski K,Knapp M,Szmitkowski M

    更新日期:2010-08-01 00:00:00

  • Influence of different types of stressors on the waveform of the peripheral arterial pulse in humans.

    abstract:BACKGROUND:To characterize further the different reflected waves visible at the peripheral arterial pressure waveform, we recorded changes in the pulse wave contour during different stressful interventions. METHODS:Ten young healthy volunteers underwent two protocols. At the first occasion, the digital arterial pressu...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Ahlund C,Pettersson K,Lind L

    更新日期:2003-01-01 00:00:00

  • C-reactive protein and nitric oxide level in patients with white coat hypertension.

    abstract:BACKGROUND:There are controversial results regarding the endothelial function in patients with white coat hypertension (WCH). The aim of this study was to assess endothelial function measuring nitric oxide (NO) and C-reactive protein (CRP) level in WCH and to compare those with essential hypertension (EH) and healthy s...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Guven A,Tolun F,Caliskan M,Ciftci O,Muderrisoglu H

    更新日期:2012-10-01 00:00:00

  • Hypertension and antihypertensive treatment in HIV-infected individuals. A longitudinal cohort study.

    abstract:OBJECTIVES:Hypertension is a significant contributor to cardiovascular disease in HIV-infected individuals. The purposes of this study were to assess the development of new-onset hypertension and the use of antihypertensive treatment and blood pressure (BP) control. METHODS:In a longitudinal study of 434 HIV-infected ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Manner IW,Baekken M,Oektedalen O,Os I

    更新日期:2012-10-01 00:00:00

  • Insulin resistance and sympathetic nervous system activity in hypertensive and normotensive premenopausal women.

    abstract::The aim of the present study was to compare insulin sensitivity and catecholamine responses to insulin in lean, hypertensive (HT) and normotensive (NT) premenopausal women. HT (BP 149 5/99 +/- 2 mmHg, n = 14) and NT (BP 128 +/- 4/81 +/- 2 mmHg, n = 12) were matched for age (46 +/- 1 vs. 47 +/- 1 years) and body mass i...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Nordby G,Moan A,Kjeldsen SE,Eide IK,Os I

    更新日期:1995-09-01 00:00:00

  • Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: a multicenter, randomized, double-blind study.

    abstract:INTRODUCTION:The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol. METHODS:Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essent...

    journal_title:Blood pressure

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Redón J,Pascual-Izuel JM,Rodilla E,Vicente A,Oliván J,Bonet J,Torguet JP,Calaforra O,Almirall J

    更新日期:2014-06-01 00:00:00

  • Determinants of hypertension control in a large French population of treated hypertensive subjects.

    abstract::Only a minority of all hypertensives is well controlled in the population. In order to assess the proportion of well controlled hypertensives and the factors associated with hypertension control in France, we designed an observational cross-sectional epidemiological study in a population of 4702 treated adult hyperten...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Roux O,Chapellier M,Czernichow S,Nisse-Durgeat S,Safar ME,Blacher J

    更新日期:2006-01-01 00:00:00

  • Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk.

    abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...

    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Olsen E,Holzhauer B,Julius S,Kjeldsen SE,Larstorp ACK,Mancia G,Mehlum MH,Mo R,Rostrup M,Søraas CL,Zappe D,Weber MA

    更新日期:2021-01-06 00:00:00

  • Association of elevated blood pressure during exercise with cerebral white matter lesions.

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    journal_title:Blood pressure

    pub_type: 杂志文章


    authors: Yang WI,Kim IJ,Kim MS,Kim SH,Moon JY,Sung JH,Lim SW,Cha DH,Cho SY

    更新日期:2018-06-01 00:00:00