Lack of association of the renin-angiotensin system genes polymorphisms and left ventricular hypertrophy in hypertension.

Abstract:

OBJECTIVE:The aim of the present study was to determine if there is an association of different gene polymorphisms of renin-angiotensin system and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St Petersburg population. PATIENTS AND METHODS:We examined 156 patients (the mean age 49+/-8 years) with mild-to-moderate EH recruited from the general population of the outpatient clinic. Left ventricular mass was measured by echocardiography and left ventricular mass index (LVMI) was calculated. Subjects were genotyped for I/D polymorphism of the angiotensin-converting enzyme (ACE) gene, A1166C polymorphism of the AT1 receptor gene, M235T polymorphism of angiotensinogen gene and -6G/A polymorphism of its promoter region. RESULTS:Genotype distribution of the sample obeyed Hardy-Weinberg equilibrium and was comparable to that reported previously for hypertensive individuals. Groups of patients with II, ID and DD polymorphism of ACE gene did not differ significantly in their LVMI levels. Furthermore, neither ID ACE-gene polymorphism nor ATI-receptor gene and angiotensinogen gene polymorphism was associated with LVH. Additionally, no any significant gene-gene interactions were found to be associated with LVH in the group studied. CONCLUSIONS:In the light of these observations it seems reasonable to make a preliminary conclusion about lack of association between LVH and distinct polymorphisms of renin-angiotensin system genes in the population studied.

journal_name

Blood Press

journal_title

Blood pressure

authors

Shlyakhto EV,Shwartz EI,Nefedova YB,Zukova AV,Vinnic TA,Conrady AO

doi

10.1080/080370501753182343

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

135-41

issue

3

eissn

0803-7051

issn

1651-1999

journal_volume

10

pub_type

杂志文章
  • Prevalence of left ventricular hypertrophy detected by Cornell voltage-duration product in a hypertensive population.

    abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...

    journal_title:Blood pressure

    pub_type: 杂志文章,多中心研究

    doi:10.1080/08037050802059092

    authors: Barrios V,Escobar C,Calderon A,Ribas L,Marti D,Asin E

    更新日期:2008-01-01 00:00:00

  • Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes.

    abstract::There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure. Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetyl...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.481808

    authors: Biala A,Tauriainen E,Siltanen A,Shi J,Merasto S,Louhelainen M,Martonen E,Finckenberg P,Muller DN,Mervaala E

    更新日期:2010-06-01 00:00:00

  • Office blood pressure measurements with oscillometric devices in adolescents: a comparison with home blood pressure.

    abstract:PURPOSE:Compare multiple in office BP measurements in adolescents using an oscillometric device with out-of-office blood pressure measurements (home blood pressure monitoring - HBPM). MATERIALS AND METHODS:Office measurements were performed with validated semi-automatic devices twice (3 minutes interval) in two differ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2017.1312279

    authors: Jardim TV,Gaziano TA,Nascente FM,Carneiro CS,Morais P,Roriz V,Mendonça KL,Póvoa TIR,Barroso WKS,Sousa ALL,Jardim PCV

    更新日期:2017-10-01 00:00:00

  • Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and substance P.

    abstract::In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059209077667

    authors: Edvinsson L,Erlinge D,Ekman R,Thulin T

    更新日期:1992-12-01 00:00:00

  • Post-marketing surveillance study of valsartan/amlodipine combination in Taiwanese hypertensive patients.

    abstract:AIMS:To assess safety and efficacy of valsartan/amlodipine combination in hypertensive Taiwanese patients. METHODS:This 12-week, multi-center, prospective, observational, post-marketing study enrolled 1029 patients to receive valsartan/amlodipine combination alone or as add-on to other antihypertensives. Efficacy was ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/08037051.2012.697629

    authors: Cheng SM,Mar GY,Huang SC,Chen CS,Hsieh CM,Huang LC,Ueng KC

    更新日期:2012-07-01 00:00:00

  • Hypertension in pregnancy and size at birth.

    abstract::Low birth weight and high placental weight are associated with increased cardiovascular morbidity and mortality. Children born after hypertensive pregnancies have higher blood pressure than children born after normotensive pregnancies. Hypertension in pregnancy is considered a major risk factor for intrauterine growth...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059609078060

    authors: Himmelmann K,Himmelmann A,Niklasson A,Svensson A

    更新日期:1996-09-01 00:00:00

  • Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk.

    abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1856642

    authors: Olsen E,Holzhauer B,Julius S,Kjeldsen SE,Larstorp ACK,Mancia G,Mehlum MH,Mo R,Rostrup M,Søraas CL,Zappe D,Weber MA

    更新日期:2021-01-06 00:00:00

  • Central hemodynamics in relation to low-level environmental lead exposure.

    abstract::Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population.Materials an...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2019.1658518

    authors: Yu CG,Wei FF,Zhang ZY,Thijs L,Yang WY,Mujaj B,Feng YM,Boggia J,Roels HA,Struijker-Boudier HAJ,Nawrot TS,Verhamme P,Staessen JA

    更新日期:2020-06-01 00:00:00

  • Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females.

    abstract::We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050600650191

    authors: Suwazono Y,Kobayashi E,Uetani M,Miura K,Morikawa Y,Ishizaki M,Kido T,Nakagawa H,Nogawa K

    更新日期:2006-01-01 00:00:00

  • Effects of low sodium diet and unilateral nephrectomy on the development of carbohydrate-induced hypertension.

    abstract::Since there appear to be important interactions between mechanisms of salt-sensitive and carbohydrate-sensitive hypertension, the goal of this study was to evaluate the effects of greatly reducing dietary salt intake and removal of one kidney (to increase salt sensitivity) on the hemodynamic and metabolic responses to...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077589

    authors: Donnelly R,Ho H,Reaven GM

    更新日期:1995-05-01 00:00:00

  • The Bergen Blood Pressure Study: inappropriately low levels of circulating atrial natriuretic peptide in offspring of hypertensive families.

    abstract::Plasma atrial natriuretic peptide (ANP), plasma and 24-h urine catecholamines, plasma renin activity (PRA), and serum aldosterone were studied in offspring of hypertensive and normotensive families [n = 82; age 37 +/- 7 years (mean +/- SD)]. Despite higher age, higher blood pressure, and higher urine excretion of cate...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059409102261

    authors: Mo R,Myking OL,Lund-Johansen P,Omvik P

    更新日期:1994-07-01 00:00:00

  • Short- and long-term effects of the use of RAAS blockers immediately after renal transplantation.

    abstract:BACKGROUND:The efficacy and safety of renin angiotensin aldosterone system blockers (RAASB's) if introduced immediately after renal transplantation have not been extensively investigated. METHODS:The medical charts of 142 kidney transplant recipients who received a RAASB in the early postoperative period and of 114 ma...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037051.2016.1182856

    authors: Chatzikyrkou C,Eichler J,Karch A,Clajus C,Scurt FG,Ramackers W,Lehner F,Menne J,Haller H,Mertens PR,Schiffer M

    更新日期:2017-02-01 00:00:00

  • Interaction of the C-344T polymorphism of CYP11b2 gene with body mass index and waist circumference affecting diastolic blood pressure in Chinese Mongolian population.

    abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.495859

    authors: Pan X,Liu Y,Zhang Y,Zhang X,Xu Q,Tong W

    更新日期:2010-12-01 00:00:00

  • HYDRA: possible determinants of unsatisfactory hypertension control in German primary care patients.

    abstract::The Hypertension and Diabetes Screening and Awareness (HYDRA) study is a cross-sectional point-prevalence study performed in September 2001; 45,125 primary care attendees were recruited from a representative nationwide sample of 1912 primary care practices in Germany. Around 42% of all patients presenting in these pra...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050310030982

    authors: Steckelings UM,Stoppelhaar M,Sharma AM,Wittchen HU,Krause P,Küpper B,Kirch W,Pittrow D,Ritz E,Göke B,Lehnert H,Tschöpe D,Höfler M,Pfister H,Unger T,HYDRA Study Group.

    更新日期:2004-01-01 00:00:00

  • Twenty-four-hour and conventional blood pressure components and risk of preterm delivery or neonatal complications in gestational hypertension.

    abstract::Gestational hypertension is a recognized risk factor for the development of complications during pregnancy. The present study retrospectively assessed the respective values of blood pressure components derived from conventional and 24-h recordings (ABPM) as predictors of premature delivery in women with gestational hy...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050902836753

    authors: Liro M,Gasowski J,Wydra D,Grodzicki T,Emerich J,Narkiewicz K

    更新日期:2009-01-01 00:00:00

  • Hypertension and cochlear hearing loss.

    abstract::This paper presents a review of experimental and clinical research on the contribution of hypertension to cochlear hearing loss. Hypertension is one of the crucial risk factors underlying pathophysiological processes taking place in the cochlea. Several mechanisms explaining these processes have been described, mainly...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.3109/08037051.2015.1049466

    authors: Przewoźny T,Gójska-Grymajło A,Kwarciany M,Gąsecki D,Narkiewicz K

    更新日期:2015-01-01 00:00:00

  • L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension.

    abstract::Sympathetic nerve activity is augmented by calcium-channel blocker treatment as a result of decreased blood pressure. Dihydropyridine calcium-channel blockers are divided into three different types. The purpose of the present study was to investigate whether treatment effects on hemodynamics, cardiac autonomic nerve a...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/08037051.2012.694200

    authors: Ogura C,Ono K,Miyamoto S,Ikai A,Mitani S,Sugimoto N,Tanaka S,Fujita M

    更新日期:2012-12-01 00:00:00

  • Effects of amlodipine and candesartan on oxidized LDL level in patients with mild to moderate essential hypertension.

    abstract:OBJECTIVE:To compare the effects of amlodipine and candesartan on oxidized low-density lipoprotein (OxLDL), conjugated dienes (CD) and baseline diene conjugation in circulating low-density lipoproteins (LDL-BDC) level during antihypertensive treatment. METHODS:Forty-nine patients with untreated mild to moderate essent...

    journal_title:Blood pressure

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/08037050601037844

    authors: Muda P,Kampus P,Teesalu R,Zilmer K,Ristimäe T,Fischer K,Zilmer M

    更新日期:2006-01-01 00:00:00

  • Association of elevated blood pressure during exercise with cerebral white matter lesions.

    abstract:OBJECTIVES:Cerebral white matter lesions (WMLs) are regarded to be subclinical ischemic changes of the cerebral parenchyma. Many previous studies have shown that baseline blood pressure (BP) is one of the most important factors for WMLs, but the relation between exercise BP and WMLs has not been fully evaluated. So, we...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2018.1423544

    authors: Yang WI,Kim IJ,Kim MS,Kim SH,Moon JY,Sung JH,Lim SW,Cha DH,Cho SY

    更新日期:2018-06-01 00:00:00

  • Development of insulin resistance and elevated blood pressure during therapy with cyclosporine A.

    abstract:OBJECTIVES:Essential hypertension and insulin resistance frequently coexist; cyclosporine A (CsA) is known to induce hypertension which has been used as a model for essential hypertension. The present study aimed to evaluate whether elevated blood pressure and insulin resistance coexist during CsA therapy to prove the ...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.3109/08037059709086440

    authors: Kutkuhn B,Hollenbeck M,Heering P,Koch M,Voiculescu A,Reinhard T,Grabensee B

    更新日期:1997-01-01 00:00:00

  • White coat hypertension and carotid atherosclerosis.

    abstract::To investigate further the relationship between atherosclerotic vascular disease and blood pressure, and the phenomenon of white coat hypertension, we performed a cross-sectional study of patients referred for carotid Doppler scanning, to determine the relationship between ambulatory blood pressure monitoring (ABPM) a...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370599439652

    authors: Landray MJ,Sagar G,Murray S,Beevers M,Beevers DG,Lip GY

    更新日期:1999-01-01 00:00:00

  • Diagnostic criteria of white coat hypertension (WCH): consequences for the implications of WCH for target organs.

    abstract::In a sample comprising 51 normotensive subjects and 51 subjects with in-clinic arterial hypertension [blood pressures (BPs) > or = 140/90 mmHg), we investigated the prevalence of target organ damage [left ventricular hypertrophy (LVH) and retinal vasculopathy] in white coat hypertension (WCH) groups defined using: (a)...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370502760050377

    authors: Pose-Reino A,Rodríguez-Fernández M,López-Barreiro L,Coleman IC,Estévez-Nuñez JC,Méndez-Naya I

    更新日期:2002-01-01 00:00:00

  • Metabolic syndrome and cardiometabolic risk: an update.

    abstract::Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.1080/08037050802677695

    authors: Grassi G,Seravalle G,Quarti-Trevano F,Dell'Oro R,Bombelli M,Mancia G

    更新日期:2009-01-01 00:00:00

  • Intraplatelet free calcium concentrations and alcohol-related blood pressure elevation in a middle-aged male population.

    abstract::Elevated intracellular free calcium (Ca2+) has been proposed as a mechanism of alcohol-induced hypertension from animal experimental studies, but this has not been confirmed in man. In the present study, intraplatelet Ca2+ concentration (plt.[Ca2+]i) was measured in 83 middle-aged men, and the associations between alc...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077576

    authors: Ikai E,Ishizaki M,Tsuritani I,Ishida M,Noborisaka Y,Yamada Y

    更新日期:1995-03-01 00:00:00

  • Effects of leptin and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.

    abstract::Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic synd...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037051.2016.1192945

    authors: de Faria AP,Ritter AM,Sabbatini AR,Modolo R,Moreno H

    更新日期:2017-04-01 00:00:00

  • Determinants of the awakening rise in systemic blood pressure in obstructive sleep apnea syndrome.

    abstract::To investigate the factors responsible for the morning rise in blood pressure (BP) in obstructive sleep apnea syndrome (OSAS) we examined a group of 253 consecutive snorers or OSAS patients. On the basis of their AHI the patients were classified in four groups. BP was measured on the evening before sleep onset and on ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077598

    authors: Sforza E,Lugaresi E

    更新日期:1995-07-01 00:00:00

  • Limitation of physical activity, dyspnea and chest pain prior to and during two years after coronary artery bypass grafting in relation to a history of hypertension.

    abstract:AIM:To describe the limitation of physical activity, the cause of limitation of physical activity and symptoms of dyspnea and chest pain before and 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. METHODS:All patients from western Sweden who underwent CABG between 1988 and...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059709062094

    authors: Herlitz J,Caidahl K,Albertsson P,Karlsson T,Hartford M,Haglid M,Lurje L,Karlson BW,Sjöland H

    更新日期:1997-11-01 00:00:00

  • Home blood pressure measurements: advantages and disadvantages compared to office and ambulatory monitoring.

    abstract::Home blood pressure monitoring (HBPM) is an easy and standardized tool to measure blood pressure (BP) at home, which is recommended by several national and international guidelines to obtain reliable BP values. It is a useful and dependable measure of BP, which can add information to the more common and standardized m...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.3109/08037051.2015.1070599

    authors: Bonafini S,Fava C

    更新日期:2015-01-01 00:00:00

  • Blood pressure circadian rhythm and variability in subjects with severe heart failure.

    abstract::To explore whether a condition of severe heart failure results in alteration of the 24-h-blood pressure (BP) profile and BP circadian rhythm, 19 patients with severe heart failure (NYHA class III-IV, 17M, 2F, mean age 57+/-8 years) were considered and compared to a control group of age- and sex-matched normal subjects...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/080370598437132

    authors: Moroni C,De Biase L,Pannarale G,Bondanini F,Affricano D,Campa PP,Cassone R

    更新日期:1998-11-01 00:00:00

  • Association of retinal microvascular caliber with blood pressure levels.

    abstract:BACKGROUND:The most common ophthalmologic manifestation of hypertension is hypertensive retinopathy. Our study was designed to evaluate the factors that determine retinal vessel caliber in hypertensive subjects. METHODS:During a 6-month period, retinal photographs were taken of participants during a routine yearly che...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2012.645336

    authors: Gepstein R,Rosman Y,Rechtman E,Koren-Morag N,Segev S,Assia E,Grossman E

    更新日期:2012-06-01 00:00:00