Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females.

Abstract:

:We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and lifestyle. Our cohort consisted of 1444 males and 1161 females selected from 3834 male and 2591 female workers in a single company. Hypertension was defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg or the use of antihypertensive medication. Because the RR genotype was so rare (three normotensive males and three normotensive females), they were excluded from analyses. Genotype distributions for Q89R in hypertensive females (QR = 14, QQ = 60) were significantly different (p = 0.033) from normotensive females (QR = 113, QQ = 971). In contrast, those in hypertensive males (QR = 26, QQ = 230) and in normotensive males (QR = 145, QQ = 1040) were similar. Allele distributions were not significantly different in either gender. In females, multivariate logistic regression showed that the QR genotype was associated with hypertension with odds ratio of 2.1 compared to the QQ genotype. This study indicates that the Q89R polymorphism is an independent factor for hypertension in Japanese females.

journal_name

Blood Press

journal_title

Blood pressure

authors

Suwazono Y,Kobayashi E,Uetani M,Miura K,Morikawa Y,Ishizaki M,Kido T,Nakagawa H,Nogawa K

doi

10.1080/08037050600650191

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

80-7

issue

2

eissn

0803-7051

issn

1651-1999

pii

Q273H334242Q023W

journal_volume

15

pub_type

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