Abstract:
:To investigate further the relationship between atherosclerotic vascular disease and blood pressure, and the phenomenon of white coat hypertension, we performed a cross-sectional study of patients referred for carotid Doppler scanning, to determine the relationship between ambulatory blood pressure monitoring (ABPM) and carotid atherosclerosis. We studied 79 patients (51 men, 28 women) undergoing Doppler ultrasound examination of the carotid arteries: 44 (56%) had evidence of carotid atherosclerosis on Doppler ultrasound examination ("disease group"), whilst 35 (44%) had normal carotid arteries ("controls"). "Adequate" ABPM recordings, defined by > 90% of recordings over the 24 h, were available in 51 patients (30 positive, 21 negative). There were no significant differences in mean daytime, mean night-time or mean 24 h ABPM recordings between those with and without carotid atherosclerosis. Mean manual clinic systolic blood pressure was significantly greater in those with carotid atherosclerosis than in controls (146.7 +/- 25.2 vs 131.1 +/- 35 mmHg, p < 0.005). In patients with carotid atherosclerosis, the first systolic blood pressure ABPM recording was not significantly different from the mean manual clinic recording (mean difference -1.5 mmHg, 95% confidence interval (CI) -7.9 to 4.8 mmHg). The initial diastolic blood pressure ABPM recording was significantly higher than the mean manual recording. Carotid atherosclerosis was identified in 53% of normotensive controls compared with 56% of white coat hypertensives and 75% of persistent hypertensives. One-third (9/27) of the patients with normal carotid arteries did not have nocturnal dipping ("non-dippers") compared with 50% (12/24) of the atherosclerotic patients. This study suggests that carotid atherosclerosis may be associated with white coat hypertension. Our study adds to the body of evidence that white coat hypertension is associated with end-organ damage and is not simply a benign disease. Such patients should be screened for other cardiovascular risk factors and should be monitored for the development of persistent hypertension.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Landray MJ,Sagar G,Murray S,Beevers M,Beevers DG,Lip GYdoi
10.1080/080370599439652subject
Has Abstractpub_date
1999-01-01 00:00:00pages
134-40issue
3eissn
0803-7051issn
1651-1999journal_volume
8pub_type
杂志文章相关文献
BLOOD PRESSURE文献大全abstract::Losartan represent a novel approach in the treatment of hypertension. Clinical trials have reported a very low incidence of side effects. We describe two patients who developed increases in alanine/aspartate amino transferase of 8 and 15 times the upper normal limit, as well as thoracic pain, after a short time of tre...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609062128
更新日期:1996-05-01 00:00:00
abstract::We have previously shown that the angiotensin receptor blocker valsartan is associated with a lower incidence of new-onset type 2 diabetes than that with the calcium-channel antagonist amlodipine in the treatment of hypertensive patients at high cardiovascular risk. We have now investigated the benefits of valsartan v...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.1080/08037050802169644
更新日期:2008-01-01 00:00:00
abstract::Low compliance to therapeutic regimens can have serious impact on patient health. A variety of technologies such as tablet dispensers and reminders has been developed to improve compliance. The aim of this study was to assess the acceptance of patients and physicians with regard to the functions and usefulness of a re...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037050903289598
更新日期:2009-01-01 00:00:00
abstract::Hypertensive patients who are at high risk of developing cardiovascular (CV) complications have become the focus of modern treatment guidelines. The choice of antihypertensive therapies in these patients should be evidence-based: in particular, there should be evidence of a beneficial impact on CV events in addition t...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.1080/08037050211264
更新日期:2002-01-01 00:00:00
abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.495859
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To determine the clinical profile and blood pressure (BP) control rates of anticoagulated patients with hypertension and atrial fibrillation (AF). METHODS:The PAULA study was a multicenter cross-sectional/retrospective observational study conducted throughout Spain. The study included patients with nonvalvul...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037051.2017.1313094
更新日期:2017-10-01 00:00:00
abstract::Using both in vitro and in vivo techniques, it has repeatedly been shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental hypertension (SHR, Dahl salt-sensitive rat, DOCA-salt rat and renovascular hypertension). EDV has also been found to be impaired in primary, as well as i...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500439362
更新日期:2000-01-01 00:00:00
abstract:AIMS:The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, nor...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037050903576726
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037050802059092
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. METHODS:We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050500339275
更新日期:2005-01-01 00:00:00
abstract::Blood pressure (BP) and excretory function including lithium clearance were investigated during water-loading and constant infusion of 131I-hippuran and 125I-iothalamate for measurement of renal haemodynamics in 8 untreated essential hypertensives (mean BP +/- SD: 169 +/- 14/107 +/- 6 mmHg) before and after vasodilata...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059309077525
更新日期:1993-03-01 00:00:00
abstract::The HEART project was conducted in general practice to determine whether lifestyle strategies, aimed at increasing physical activity and dietary modification, can be substituted for drug therapy in patients who have been well controlled on antihypertensive medication. In addition to blood pressure (BP) and risk factor...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/080370500448650
更新日期:2000-01-01 00:00:00
abstract::In this study we aimed to elucidate the role of central noradrenergic, dopaminergic, adrenergic and serotonergic neuronal systems in the development of essential hypertension. Fifteen untreated essential hypertensive subjects (aged 44 +/- 3 years) and 32 healthy volunteers (aged 38 +/- 3 years) participated in this st...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101522
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Abnormal left ventricular (LV) geometric patterns, particularly concentric LV hypertrophy, are associated with a greater risk of hypertensive complications. The aim of this study was to investigate the association between LV myocardial performance index (LVMPI) and aortic distensibility (AD) with different L...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2013.778006
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Compare multiple in office BP measurements in adolescents using an oscillometric device with out-of-office blood pressure measurements (home blood pressure monitoring - HBPM). MATERIALS AND METHODS:Office measurements were performed with validated semi-automatic devices twice (3 minutes interval) in two differ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2017.1312279
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.532317
更新日期:2011-04-01 00:00:00
abstract::Plasma atrial natriuretic peptide (ANP), plasma and 24-h urine catecholamines, plasma renin activity (PRA), and serum aldosterone were studied in offspring of hypertensive and normotensive families [n = 82; age 37 +/- 7 years (mean +/- SD)]. Despite higher age, higher blood pressure, and higher urine excretion of cate...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102261
更新日期:1994-07-01 00:00:00
abstract::Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic synd...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037051.2016.1192945
更新日期:2017-04-01 00:00:00
abstract:AIMS:To assess safety and efficacy of valsartan/amlodipine combination in hypertensive Taiwanese patients. METHODS:This 12-week, multi-center, prospective, observational, post-marketing study enrolled 1029 patients to receive valsartan/amlodipine combination alone or as add-on to other antihypertensives. Efficacy was ...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/08037051.2012.697629
更新日期:2012-07-01 00:00:00
abstract::Having found that circulating adrenaline (AD) is selectively elevated in stroke-prone spontaneously hypertensive rats (SHRSP) compared with Wistar-Kyoto rats (WKY), we extended the comparison to include other normotensive and hypertensive rat strains. Aortic catheters were implanted in young (5-7 weeks) and old (7-9 m...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101529
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function. METHODS:Fifteen young (26 +/- 4 years) healthy normotensive (115 +/- 8/71 +/- 6 mmHg) subjects with a FHH, 31 matched healt...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370502320779485
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To compare the effects of amlodipine and candesartan on oxidized low-density lipoprotein (OxLDL), conjugated dienes (CD) and baseline diene conjugation in circulating low-density lipoproteins (LDL-BDC) level during antihypertensive treatment. METHODS:Forty-nine patients with untreated mild to moderate essent...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.1080/08037050601037844
更新日期:2006-01-01 00:00:00
abstract::BACKGROUND. Ganglioneuromas (GNs) are neural crest cell-derived tumors and rarely occur in the adrenal gland. They are usually asymptomatic and hormonally silent. The majority of cases are detected incidentally during work-up for unrelated conditions. Hormone-secreting pure adrenal GNs in adults are extremely rare. To...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037051.2013.796103
更新日期:2014-02-01 00:00:00
abstract::Plasma level of adrenaline has been reported to be elevated in borderline hypertension. However, its role in developing and maintaining hypertension is still not completely understood. This study aimed to estimate the role of plasma adrenaline in developing hypertension. Ten patients with borderline hypertension (BHT)...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077578
更新日期:1995-03-01 00:00:00
abstract::The purpose of this study was to test the hypothesis of a causal relationship between high insulin levels and the development of benign prostatic hyperplasia (BPH) and to determine the clinical, anthropometric, metabolic and insulin profile in men with fast-growing BPH compared with men with slow-growing BPH. The pres...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370599438365
更新日期:1999-01-01 00:00:00
abstract::The effectiveness of hypertension treatment remains low in many developed countries. The aim of our study was to evaluate the treatment effectiveness in hypertensives treated by general practitioners (GPs) in Poland. Twenty thousand three hundred and five hypertensive patients (mean age 60.1 +/- 12.0 years, 9918 women...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310015458
更新日期:2003-01-01 00:00:00
abstract::We compared the effects of amlodipine and verapamil slow release on autonomic responses to a 5-min mental arithmetic test (MST) in patients with mild to moderate hypertension. Twenty subjects received 8 weeks of verapamil slow release 240 mg or amlodipine 10 mg in a double-blind crossover design, both after 4 weeks' p...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/08037050152112096
更新日期:2001-01-01 00:00:00
abstract::This 1-year, dose-titration, General Practitioner (GP) study compared efficacy, tolerability and safety of oral temocapril (10-40 mg once daily) with atenolol (25-100 mg once daily) in mild to moderate adult hypertensives (diastolic blood pressure (DBP) 95-114 mmHg). A 12-week dose-titration period, randomized 3:1 tem...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/08037059709062074
更新日期:1997-07-01 00:00:00
abstract::Purpose: Previous studies that evaluated the prevalence of hypertension in Nigeria were either clinic based, non-standardized or did not include out-of-clinic blood pressure (BP) measurement. Materials and Methods: We selected a rural and an urban community in one state in each of the 6 geopolitical zones of Nigeria. ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1612706
更新日期:2019-08-01 00:00:00
abstract:AIMS:(1) To evaluate the prevalence of clinic blood pressure (BP) control in a large sample of treated hypertensives followed in our hypertension clinic during the year 2000, and to compare it with our 1997 data. (2) To investigate the prevalence of left ventricular hypertrophy (LVH) according to different levels of BP...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050213762
更新日期:2002-01-01 00:00:00