Abstract:
AIMS:To assess safety and efficacy of valsartan/amlodipine combination in hypertensive Taiwanese patients. METHODS:This 12-week, multi-center, prospective, observational, post-marketing study enrolled 1029 patients to receive valsartan/amlodipine combination alone or as add-on to other antihypertensives. Efficacy was evaluated by blood pressure (BP) control rate (in mmHg; non-diabetics, < 140/90; diabetics, < 130/80) at Week 12 and BP-lowering ability at Weeks 4 and 12. Additionally, responder rate (sitting-SBP < 140 for baseline SBP ≥ 140 or sitting-DBP < 90 for baseline DBP ≥ 90, or SBP reduction > 20 or DBP reduction > 10 from baseline) was determined. MAJOR FINDINGS:Adverse events (AEs) were reported in 12.15% patients; dizziness, cough, and peripheral edema were the most commonly reported AEs. Overall BP control rate was 48.27%. Greater BP reduction was noted at Week 12 than at Week 4 between all groups and subgroups. Greater SBP/DBP reduction was observed in patients with stage 2 hypertension than stage 1 hypertension at baseline. The overall responder rate was 78.52%. Subgroup analysis showed greater BP reduction in non-diabetics than diabetics; only SBP reduction reached statistical significance (- 13.7 [18.3] vs. - 10.7 [17.4] mmHg; p < 0.0093). PRINCIPAL CONCLUSION:Valsartan/amlodipine combination was well tolerated, with no safety concerns identified and an effective treatment option for hypertensive Taiwanese patients.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Cheng SM,Mar GY,Huang SC,Chen CS,Hsieh CM,Huang LC,Ueng KCdoi
10.3109/08037051.2012.697629subject
Has Abstractpub_date
2012-07-01 00:00:00pages
11-9eissn
0803-7051issn
1651-1999journal_volume
21 Suppl 1pub_type
临床试验,杂志文章,多中心研究相关文献
BLOOD PRESSURE文献大全abstract::Plasma level of adrenaline has been reported to be elevated in borderline hypertension. However, its role in developing and maintaining hypertension is still not completely understood. This study aimed to estimate the role of plasma adrenaline in developing hypertension. Ten patients with borderline hypertension (BHT)...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077578
更新日期:1995-03-01 00:00:00
abstract::The familial aggregation of hypertension is well documented. However, many studies on the familial predisposition have suffered from insufficient knowledge of parental blood pressure (BP). In the present study, the family history is defined according to parental data from two BP surveys conducted almost 30 years apart...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209077668
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:To determine the factors influencing general practitioners' prescribing for patients with moderate hypertension, and to investigate their ability to assess patients' absolute risk of cardiovascular disease. DESIGN:Decision-making was assessed by a postal questionnaire involving five standardised example pati...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500300000897
更新日期:2000-01-01 00:00:00
abstract::An estimate of arterial compliance--the stroke volume/pulse pressure ratio (SV/PP)--was studied in 801 participants in the Tecumseh Blood Pressure Study, a population-based ongoing cardiovascular, epidemiological investigation. The subjects were normal young adults (mean age 30 +/- 5.6 years) and 373 were females. Car...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209065121
更新日期:1992-05-01 00:00:00
abstract:AIM:We determined the effect of wearing clothes under the manometer's cuff on blood pressure in manual auscultatory sphygmomanometric and automatic oscillometric blood pressure measurement. METHODS:Two hundred and one subjects were examined with the auscultatory sphygmomanometric and the automatic oscillometric method...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/08037050410016465
更新日期:2004-01-01 00:00:00
abstract::We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050600650191
更新日期:2006-01-01 00:00:00
abstract::Serotonin stimulates phospholipase A(2)(PLA(2)) leading to the production of prostaglandin products, several of which are vasoconstrictors. We hypothesised that the elevated vascular responsiveness to serotonin in deoxycorticosterone acetate (DOCA)-hypertensive rats is due in part to augmented production of vasoconstr...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609062117
更新日期:1996-03-01 00:00:00
abstract::A model of aortic ligation in mice with a hydronephrotic kidney (absence of macula densa) was used to determine the effects of aortic ligation on the renal renin-angiotensin system (RAS). Blood pressure increased from 83 +/- 2 to 133 +/- 8 mmHg within 7 days after aortic ligation (p < 0.01). Aortic ligation increased ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370599438301
更新日期:1999-01-01 00:00:00
abstract::The second Swedish Trial in Old patients with Hypertension (STOP-Hypertension-2) was conducted to compare the effects of 'newer( antihypertensive therapies (angiotensin converting enzyme [ACE] inhibitors and calcium antagonists) and established therapies (beta-blockers and diuretics) on cardiovascular mortality and mo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/blo.9.2.17.20
更新日期:2000-01-01 00:00:00
abstract::This paper presents a review of experimental and clinical research on the contribution of hypertension to cochlear hearing loss. Hypertension is one of the crucial risk factors underlying pathophysiological processes taking place in the cochlea. Several mechanisms explaining these processes have been described, mainly...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037051.2015.1049466
更新日期:2015-01-01 00:00:00
abstract::In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209077667
更新日期:1992-12-01 00:00:00
abstract::Gestational hypertension is a recognized risk factor for the development of complications during pregnancy. The present study retrospectively assessed the respective values of blood pressure components derived from conventional and 24-h recordings (ABPM) as predictors of premature delivery in women with gestational hy...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050902836753
更新日期:2009-01-01 00:00:00
abstract::Prehypertension is associated with increased cardiovascular events. While the "tracking phenomenon" is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP tre...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2015.1121708
更新日期:2016-06-01 00:00:00
abstract::The balance between matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) plays a key role in the development of hypertension and obesity. We aimed to evaluate the levels of MMP-2 and 9 and TIMP-2 and -1 in obese and non-obese apparent treatment-resistant hypertensive subjects (aTRH) and its association w...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037051.2016.1249336
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to determine if there is an association of different gene polymorphisms of renin-angiotensin system and left ventricular hypertrophy (LVH) in patients with essential hypertension (EH) in St Petersburg population. PATIENTS AND METHODS:We examined 156 patients (the mean age 49+...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370501753182343
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To study whether the cardiovascular preventive effect of antihypertensive therapy can be explained solely by the reduction in office blood pressure, and to what extent the risk of stroke and cardiac events is associated with in-study diastolic blood pressure (DBP) and systolic blood pressure (SBP). DESIGN:Th...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/08037059209077513
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND/AIMS:The aim was to evaluate the level of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and retinol binding protein (RBP) in children with primary hypertension and no features of hypertensive nephropathy. METHODS:The study group consisted of 19 children (15 males) aged 14.8 ± 2.1...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2012.666393
更新日期:2012-08-01 00:00:00
abstract::The study explored the relationship between time- and frequency-domain indices of cardiac autonomic control and 24 h blood pressure variability (BPV) in a sample of healthy men and women. Vagally mediated cardiac control was inversely related to 24 h BPV, and measures of cardiac autonomic control were better predictor...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1090721
更新日期:2016-01-01 00:00:00
abstract::Arterial hypertension is accompanied by increased morbidity and mortality and constitutes a substantial part of medical care. Antihypertensive intervention reduces the cardiovascular morbidity and mortality. The aims of the study were to evaluate the relationship between cardiovascular risk factors and the blood press...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050050151780
更新日期:2000-01-01 00:00:00
abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709061808
更新日期:1997-03-01 00:00:00
abstract::The effects of spirapril and isradipine on blood pressure, urinary albumin excretion and sodium-volume homeostasis in hypertensive insulin-dependent diabetic patients with nephropathy were assessed. Fifteen Type 1 diabetic patients aged 28-53 years with a diabetes duration of 19-37 years were studied. All had hyperten...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/08037059309077172
更新日期:1993-12-01 00:00:00
abstract:AIMS:The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, nor...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037050903576726
更新日期:2010-08-01 00:00:00
abstract::To investigate if increased lipid peroxidation is involved in hypercholesterolemia-induced hypertension and renal injury, we examined the effects of allopurinol, a xanthine oxidase inhibitor, on these conditions. Groups of male Sprague--Dawley rats were fed for 8 weeks with a high-cholesterol diet (4% cholesterol), a ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050510008878
更新日期:2005-01-01 00:00:00
abstract::In this study we aimed to elucidate the role of central noradrenergic, dopaminergic, adrenergic and serotonergic neuronal systems in the development of essential hypertension. Fifteen untreated essential hypertensive subjects (aged 44 +/- 3 years) and 32 healthy volunteers (aged 38 +/- 3 years) participated in this st...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101522
更新日期:1994-03-01 00:00:00
abstract::In order to study the role of opioid receptors in two models of experimental hypertension the binding of 3H-naloxone to membranes prepared from discrete brain regions and spinal cord was determined. Renal hypertensive rats (RHR) were found to have a greater density of 3H-naloxone binding sites in the hippocampus and h...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102254
更新日期:1994-05-01 00:00:00
abstract::In a previous study we investigated the differential time courses of the vasodilator effect of various calcium antagonists (CA) in small isolated rat mesenteric arteries (van der Lee et al., Fundam Clin Pharmacol, 1998: 12: 607-12). We concluded that the differences observed could be due to differences in lipophilicit...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037050152669738
更新日期:2001-01-01 00:00:00
abstract::The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the ap...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1156905
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.532317
更新日期:2011-04-01 00:00:00
abstract::In order to study the contribution of the nitric oxide (NO)-pathway to cholinergic vasodilatation in the resistance vessels of the human forearm, we infused acetylcholine (ACh; 0.1 1000 ng/kg/min) or methacholine (MCh; 0.1 A 100 ng/kg/min) in the presence of saline, the NO-scavenger and guanylate cyclase inhibitor met...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609078071
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:Essential hypertension and insulin resistance frequently coexist; cyclosporine A (CsA) is known to induce hypertension which has been used as a model for essential hypertension. The present study aimed to evaluate whether elevated blood pressure and insulin resistance coexist during CsA therapy to prove the ...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.3109/08037059709086440
更新日期:1997-01-01 00:00:00