Effects of leptin and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.

Abstract:

:Leptin is associated to the lack of blood pressure control as well as target organ damage in resistant hypertensive (RH) subjects. Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome. We evaluated the association of these two SNPs with clinical and biochemical features in 109 apparent treatment-RH subjects (aTRH) and 125 controlled hypertensives. Homozygous genotypes GG (n = 43) vs. AA (n = 14) for rs7799039 and AA (n = 34) vs. GG (n = 26) genotypes for rs1137101 were compared in aTRH subjects. There was no difference in leptin levels among both SNPs. On the other hand, LEP SNP (GG vs. AA) associated with the levels of glycated haemoglobin (6.4 ± 1.4 vs. 7.8 ± 2.3%, p = 0.03), insulin (8.6 ± 4.6 vs. 30.6 ± 27.7 uUI/mL, p = 0.01), HDL-cholesterol (51 ± 16 vs. 39 ± 11 mg/dL, p = 0.001) and PWV (9.5 ± 2.1 vs. 11.2 ± 2.8 m/s, p = 0.03). LEPR SNP (AA vs. GG), associated with heart rate (69 ± 12 vs. 67 ± 12 bpm, p = 0.03), fat mass (31 ± 11 vs. 24 ± 8 kg, p = 0.03) and triglycerides levels (175 ± 69 vs. 135 ± 75 mg/dL, p = 0.03). These findings may be clinically useful for identifying a group of aTRH who may have a LEP and/or LEPR gene variants, which may predispose this specific group to worse or better outcomes.

journal_name

Blood Press

journal_title

Blood pressure

authors

de Faria AP,Ritter AM,Sabbatini AR,Modolo R,Moreno H

doi

10.1080/08037051.2016.1192945

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

74-80

issue

2

eissn

0803-7051

issn

1651-1999

journal_volume

26

pub_type

临床试验,杂志文章
  • Prevalence of left ventricular hypertrophy detected by Cornell voltage-duration product in a hypertensive population.

    abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...

    journal_title:Blood pressure

    pub_type: 杂志文章,多中心研究

    doi:10.1080/08037050802059092

    authors: Barrios V,Escobar C,Calderon A,Ribas L,Marti D,Asin E

    更新日期:2008-01-01 00:00:00

  • Results of the STOP-Hypertension-2 Trial.

    abstract::The second Swedish Trial in Old patients with Hypertension (STOP-Hypertension-2) was conducted to compare the effects of 'newer( antihypertensive therapies (angiotensin converting enzyme [ACE] inhibitors and calcium antagonists) and established therapies (beta-blockers and diuretics) on cardiovascular mortality and mo...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/blo.9.2.17.20

    authors: Hansson L

    更新日期:2000-01-01 00:00:00

  • Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk.

    abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1856642

    authors: Olsen E,Holzhauer B,Julius S,Kjeldsen SE,Larstorp ACK,Mancia G,Mehlum MH,Mo R,Rostrup M,Søraas CL,Zappe D,Weber MA

    更新日期:2021-01-06 00:00:00

  • Office blood pressure measurements with oscillometric devices in adolescents: a comparison with home blood pressure.

    abstract:PURPOSE:Compare multiple in office BP measurements in adolescents using an oscillometric device with out-of-office blood pressure measurements (home blood pressure monitoring - HBPM). MATERIALS AND METHODS:Office measurements were performed with validated semi-automatic devices twice (3 minutes interval) in two differ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2017.1312279

    authors: Jardim TV,Gaziano TA,Nascente FM,Carneiro CS,Morais P,Roriz V,Mendonça KL,Póvoa TIR,Barroso WKS,Sousa ALL,Jardim PCV

    更新日期:2017-10-01 00:00:00

  • The acute effect of continuous positive airway pressure titration on blood pressure in awake overweight/obese patients with obstructive sleep apnoea.

    abstract:OBJECTIVES:Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular syst...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:10.1080/08037051.2018.1443391

    authors: Ratneswaran C,Pengo MF,Xiao S,Luo Y,Rossi GP,Polkey MI,Moxham J,Steier J

    更新日期:2018-08-01 00:00:00

  • C-reactive protein and nitric oxide level in patients with white coat hypertension.

    abstract:BACKGROUND:There are controversial results regarding the endothelial function in patients with white coat hypertension (WCH). The aim of this study was to assess endothelial function measuring nitric oxide (NO) and C-reactive protein (CRP) level in WCH and to compare those with essential hypertension (EH) and healthy s...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2011.649541

    authors: Guven A,Tolun F,Caliskan M,Ciftci O,Muderrisoglu H

    更新日期:2012-10-01 00:00:00

  • Blood pressure level and relation to other cardiovascular risk factors in male hypertensive patients without clinical evidence of ischemic heart disease.

    abstract::Arterial hypertension is accompanied by increased morbidity and mortality and constitutes a substantial part of medical care. Antihypertensive intervention reduces the cardiovascular morbidity and mortality. The aims of the study were to evaluate the relationship between cardiovascular risk factors and the blood press...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050050151780

    authors: Larsen CT,Sørum C,Hansen JF,Jensen HA,Rasmussen V

    更新日期:2000-01-01 00:00:00

  • Cardiovascular and total mortality in men and women with different blood pressure levels--A 26-year follow-up.

    abstract:AIM:Our aim was to study different levels of high blood pressure and normal blood pressure (reference) to calculate the hazard ratios (HRs) for cardiovascular and total mortality in men and women with adjustments for many covariates. METHODS:A health-screening program was offered to a population-based sample in Stockh...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050903013881

    authors: Carlsson AC,Theobald H,Hellénius ML,Wändell PE

    更新日期:2009-01-01 00:00:00

  • Plasma adrenaline modulates alpha 1-adrenoceptor mediated pressor responses and the baroreflex control in patients with borderline hypertension.

    abstract::Plasma level of adrenaline has been reported to be elevated in borderline hypertension. However, its role in developing and maintaining hypertension is still not completely understood. This study aimed to estimate the role of plasma adrenaline in developing hypertension. Ten patients with borderline hypertension (BHT)...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059509077578

    authors: Minatoguchi S,Ito H,Ishimura K,Suzuki T,Tonai N,Mori M,Hirakawa S,Fujiwara H

    更新日期:1995-03-01 00:00:00

  • Life style habits, biochemical factors and their interaction in the prediction of incident hypertension during 21-year follow-up.

    abstract:BACKGROUND:Hypertension is a global health threat and major cardiovascular risk. Various risk-prediction models for incident hypertension have been developed but not many of them have studied the risk-predictive value of life style factors in combination with cardiovascular biomarkers during long-term period of over 10...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2018.1540923

    authors: Terho A,Bloigu R,Bloigu A,Niemelä O,Tulppo M,Kesäniemi YA,Ukkola O

    更新日期:2019-02-01 00:00:00

  • Prevalence of home blood pressure measurement among selected hypertensive patients: results of a multicenter survey from six hospital outpatient hypertension clinics in Italy.

    abstract:AIM:The purpose of this study was to evaluate the prevalence of home blood pressure (BP) measurement, the type of devices and accuracy in a large sample of hypertensive patients referred to hospital outpatient hypertension clinics. METHODS:Eight hundred and fifty-five consecutive treated hypertensive patients who atte...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050500210765

    authors: Cuspidi C,Meani S,Lonati L,Fusi V,Magnaghi G,Garavelli G,Palumbo G,Pini C,Vaccarella A,Parati G,Leonetti G,Zanchetti A,Lombardy Regional Section of the Italian Hypertension Society.

    更新日期:2005-01-01 00:00:00

  • Comparison of cholinergic vasodilator responses to acetylcholine and methacholine in the human forearm.

    abstract::In order to study the contribution of the nitric oxide (NO)-pathway to cholinergic vasodilatation in the resistance vessels of the human forearm, we infused acetylcholine (ACh; 0.1 1000 ng/kg/min) or methacholine (MCh; 0.1 A 100 ng/kg/min) in the presence of saline, the NO-scavenger and guanylate cyclase inhibitor met...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059609078071

    authors: Bruning TA,Chang PC,Kemme MJ,Vermeij P,Pfaffendorf M,van Zwieten PA

    更新日期:1996-11-01 00:00:00

  • Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients.

    abstract::The purpose of the study is to assess the relative impact of lifestyle factors including physical inactivity, cigarette smoking, and alcohol intake on insulin resistance in hypertensive patients. In total, 872 hypertensive patients, of Chinese and Japanese origin, from the Stanford Asia and Pacific Program for Hyperte...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050410004828

    authors: Hwu CM,Hsiao CF,Kuo SW,Wu KD,Ting CT,Quertermous T,Rodriguez B,Chen I,Grove J,Chen PY,Hoo LT

    更新日期:2004-01-01 00:00:00

  • Unattended versus two attended, ambulatory and central blood pressure measurements in hypertensive patients with and without diabetes.

    abstract:OBJECTIVE:To compare unattended blood pressure (BP) with two attended BP, with 24-h ambulatory (ABPM) and central BP measurements in hypertensive patients with (DMs) and without diabetes (HTs). METHODS:In the same hypertension clinic we evaluate 129 consecutive HTs (56% female, 59 + 16 yrs) and 91 DMs (62% female, 64 ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2019.1568184

    authors: Polonia J,Baptista C,Silva J,Barbosa L

    更新日期:2019-04-01 00:00:00

  • Hormone-secreting large adrenal ganglioneuroma in an adult patient: a case report and review of literature.

    abstract::BACKGROUND. Ganglioneuromas (GNs) are neural crest cell-derived tumors and rarely occur in the adrenal gland. They are usually asymptomatic and hormonally silent. The majority of cases are detected incidentally during work-up for unrelated conditions. Hormone-secreting pure adrenal GNs in adults are extremely rare. To...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.3109/08037051.2013.796103

    authors: Erem C,Fidan M,Civan N,Cobanoglu U,Kangul F,Nuhoglu I,Alhan E

    更新日期:2014-02-01 00:00:00

  • Hypertensive nephropathy in children - do we diagnose early enough?

    abstract:BACKGROUND/AIMS:The aim was to evaluate the level of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and retinol binding protein (RBP) in children with primary hypertension and no features of hypertensive nephropathy. METHODS:The study group consisted of 19 children (15 males) aged 14.8 ± 2.1...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2012.666393

    authors: Blumczynski A,Sołtysiak J,Lipkowska K,Silska M,Poprawska A,Musielak A,Zaniew M,Zachwieja J

    更新日期:2012-08-01 00:00:00

  • Serum uric acid and hemorheology in borderline hypertensives and in subjects with established hypertension and left ventricular hypertrophy.

    abstract::Serum uric acid (SUA) but also hemorheological parameters such as hematocrit (Hct) and whole blood viscosity (WBV) are markers of cardiovascular risk. Increased blood cell volume is one of the known causes of hyperuricemia. We therefore aimed to investigate the relationship between SUA and hemorheology in untreated bo...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章

    doi:

    authors: Höieggen A,Fossum E,Reims H,Kjeldsen SE

    更新日期:2003-01-01 00:00:00

  • Vascular stiffness and endothelial dysfunction: Correlations at different levels of blood pressure.

    abstract:UNLABELLED:Resistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance to antihypertensive treatment and cardiovascular complications. Biophysical forces within the arterial wall provide functional regulation of arterial stiffness. Caroti...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2011.617045

    authors: Figueiredo VN,Yugar-Toledo JC,Martins LC,Martins LB,de Faria AP,de Haro Moraes C,Sierra C,Coca A,Moreno H

    更新日期:2012-02-01 00:00:00

  • Metabolic syndrome and cardiometabolic risk: an update.

    abstract::Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-...

    journal_title:Blood pressure

    pub_type: 杂志文章,评审

    doi:10.1080/08037050802677695

    authors: Grassi G,Seravalle G,Quarti-Trevano F,Dell'Oro R,Bombelli M,Mancia G

    更新日期:2009-01-01 00:00:00

  • Gender differences in the relationship between resting heart rate variability and 24-hour blood pressure variability.

    abstract::The study explored the relationship between time- and frequency-domain indices of cardiac autonomic control and 24 h blood pressure variability (BPV) in a sample of healthy men and women. Vagally mediated cardiac control was inversely related to 24 h BPV, and measures of cardiac autonomic control were better predictor...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2016.1090721

    authors: Thayer JF,Sollers JJ 3rd,Friedman BH,Koenig J

    更新日期:2016-01-01 00:00:00

  • Longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease in hypertensive and normotensive adults.

    abstract::The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2020.1763158

    authors: Krajčoviechová A,Wohlfahrt P,Bruthans J,Šulc P,Lánská V,Borghi C,Cífková R

    更新日期:2020-10-01 00:00:00

  • Ambulatory monitoring predicts development of drug-treated hypertension in subjects with high normal blood pressure.

    abstract:BACKGROUND:High normal blood pressure (HNBP), i.e. blood pressure (BP) > or = 130/85 mmHg and <140/90 mmHg, is an important predictor of progression to established hypertension. DESIGN:The purpose of this retrospective study was the evaluation of the predictive value of ambulatory blood pressure monitoring (ABPM) for ...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050410021414

    authors: Pannarale G,Gaudio C,Mirabelli F,Monti F,Franchitto S,Di Michele S,Puddu PE,Fedele F

    更新日期:2004-01-01 00:00:00

  • Comparison of temocapril and atenolol in the long-term treatment of mild to moderate essential hypertension.

    abstract::This 1-year, dose-titration, General Practitioner (GP) study compared efficacy, tolerability and safety of oral temocapril (10-40 mg once daily) with atenolol (25-100 mg once daily) in mild to moderate adult hypertensives (diastolic blood pressure (DBP) 95-114 mmHg). A 12-week dose-titration period, randomized 3:1 tem...

    journal_title:Blood pressure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/08037059709062074

    authors: Sierakowski B,Püchler K,Witte PU,Renneisen K,Delius W

    更新日期:1997-07-01 00:00:00

  • Diagnostic criteria of white coat hypertension (WCH): consequences for the implications of WCH for target organs.

    abstract::In a sample comprising 51 normotensive subjects and 51 subjects with in-clinic arterial hypertension [blood pressures (BPs) > or = 140/90 mmHg), we investigated the prevalence of target organ damage [left ventricular hypertrophy (LVH) and retinal vasculopathy] in white coat hypertension (WCH) groups defined using: (a)...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370502760050377

    authors: Pose-Reino A,Rodríguez-Fernández M,López-Barreiro L,Coleman IC,Estévez-Nuñez JC,Méndez-Naya I

    更新日期:2002-01-01 00:00:00

  • Endothelium-dependent vasodilation in normotensive subjects with a familial history of essential hypertension and in young subjects with borderline hypertension.

    abstract:OBJECTIVE:To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function. METHODS:Fifteen young (26 +/- 4 years) healthy normotensive (115 +/- 8/71 +/- 6 mmHg) subjects with a FHH, 31 matched healt...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/080370502320779485

    authors: Millgård J,Hägg A,Sarabi M,Lind L

    更新日期:2002-01-01 00:00:00

  • Alcohol consumption and blood pressure in recently hospitalised patients.

    abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059709061808

    authors: Howes JB,Ryan J,Fairbrother G,O'Neill K,Howes LG

    更新日期:1997-03-01 00:00:00

  • Blood pressure-related electrocardiographic findings in healthy young individuals.

    abstract::Purpose: Elevated blood pressure induces electrocardiographic changes and is associated with an increase in cardiovascular disease later in life compared to normal blood pressure levels. The purpose of this study was to evaluate the association between normal to high normal blood pressure values (90-139/50-89 mmHg) an...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037051.2019.1673149

    authors: Hassing GJ,van der Wall HEC,van Westen GJP,Kemme MJB,Adiyaman A,Elvan A,Burggraaf J,Gal P

    更新日期:2020-04-01 00:00:00

  • Interaction of the C-344T polymorphism of CYP11b2 gene with body mass index and waist circumference affecting diastolic blood pressure in Chinese Mongolian population.

    abstract::Abstract Background. The relationship between the C-344T polymorphism of CYP11b2 gene and blood pressure (BP) is controversial. The present study aimed to investigate whether it was affected by environmental determinants in Chinese Mongolian population. Methods. A cross-sectional study was conducted between 2003 and 2...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037051.2010.495859

    authors: Pan X,Liu Y,Zhang Y,Zhang X,Xu Q,Tong W

    更新日期:2010-12-01 00:00:00

  • Effects of normal blood pressure, prehypertension and hypertension on left ventricular diastolic function and aortic elastic properties.

    abstract:BACKGROUND:The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (BP) provides guideline for the new category of BP levels as normal, prehypertension (PHT), and hypertension. Although PHT is associated with a markedly increased risk of developing h...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.1080/08037050701395910

    authors: Erdogan D,Caliskan M,Yildirim I,Gullu H,Baycan S,Ciftci O,Yildirir A,Muderrisoglu H

    更新日期:2007-01-01 00:00:00

  • The Bergen Blood Pressure Study: inappropriately low levels of circulating atrial natriuretic peptide in offspring of hypertensive families.

    abstract::Plasma atrial natriuretic peptide (ANP), plasma and 24-h urine catecholamines, plasma renin activity (PRA), and serum aldosterone were studied in offspring of hypertensive and normotensive families [n = 82; age 37 +/- 7 years (mean +/- SD)]. Despite higher age, higher blood pressure, and higher urine excretion of cate...

    journal_title:Blood pressure

    pub_type: 杂志文章

    doi:10.3109/08037059409102261

    authors: Mo R,Myking OL,Lund-Johansen P,Omvik P

    更新日期:1994-07-01 00:00:00