Effects of amlodipine and candesartan on oxidized LDL level in patients with mild to moderate essential hypertension.

Abstract:

OBJECTIVE:To compare the effects of amlodipine and candesartan on oxidized low-density lipoprotein (OxLDL), conjugated dienes (CD) and baseline diene conjugation in circulating low-density lipoproteins (LDL-BDC) level during antihypertensive treatment. METHODS:Forty-nine patients with untreated mild to moderate essential hypertension were recruited in a randomized double-blind study to receive a daily dose either of 8 mg candesartan or 5 mg amlodipine for 16 weeks. Blood pressure, OxLDL, CD, LDL-BDC, triglycerides (TG), total cholesterol and lipoprotein cholesterol were measured at baseline, at week 2 and at week 16. RESULTS:During treatment, in addition to a significant decrease in systolic and diastolic blood pressure, high level of OxLDL decreased significantly reaching practically upper kit reference values. Both treatment groups were similar with regard to the studied parameters at all time points. At the same time serum TG, lipoprotein and total cholesterol levels as well as LDL-BDC did not change and CD levels did not exceed endemic normal. Decrease in both systolic and diastolic blood pressure was associated with decrease in LDL-BDC/LDL. CONCLUSIONS:Besides their antihypertensive effects, both candesartan and amlodipine are efficient drugs for reducing OxLDL level, being neutral with regard to serum lipids.

journal_name

Blood Press

journal_title

Blood pressure

authors

Muda P,Kampus P,Teesalu R,Zilmer K,Ristimäe T,Fischer K,Zilmer M

doi

10.1080/08037050601037844

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

313-8

issue

5

eissn

0803-7051

issn

1651-1999

journal_volume

15

pub_type

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