Hypertensive nephropathy in children - do we diagnose early enough?

Abstract:

BACKGROUND/AIMS:The aim was to evaluate the level of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18) and retinol binding protein (RBP) in children with primary hypertension and no features of hypertensive nephropathy. METHODS:The study group consisted of 19 children (15 males) aged 14.8 ± 2.18 years with primary hypertension. Estimated glomerular filtration rate (eGFR) and albumin/creatinine ratio (ACR) were within the normal range. Mean blood pressure (BP) was 141/79 mmHg (mean systolic BP percentile was 98, mean diastolic BP percentile was 80). Ambulatory BP measurement (ABPM), blood and urine biochemical measurements and features of end organ damage were assessed. The control group consisted of 20 healthy children. RESULTS:Hypertensive children showed significantly increased serum and urine NGAL concentration vs controls. Urine RBP was significantly higher in the study group vs controls. A positive correlation was found between urine NGAL and the index of mean systolic BP measured in ABPM, between urine IL-18 and the index of office diastolic BP, between serum NGAL and ACR, and between urine NGAL concentration and serum HDL. CONCLUSION:In children with primary hypertension, increased serum and urine NGAL may reflect kidney injury earlier than typical markers of hypertensive nephropathy.

journal_name

Blood Press

journal_title

Blood pressure

authors

Blumczynski A,Sołtysiak J,Lipkowska K,Silska M,Poprawska A,Musielak A,Zaniew M,Zachwieja J

doi

10.3109/08037051.2012.666393

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

233-9

issue

4

eissn

0803-7051

issn

1651-1999

journal_volume

21

pub_type

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