Abstract:
:Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or without diabetes.Methods: Literature search was performed in PubMed/MEDLINE, EMBASE and BIOSIS to identify parallel-group, randomized controlled trials (≥8 weeks) reporting the effects of ARB on office systolic/diastolic BP (SBP/DBP), estimated glomerular filtration rate (eGFR), serum creatinine (SCr), creatinine clearance (CrCl) or proteinuria in adults with hypertension and CKD. Mean difference (MD, generic inverse variance) with 95% confidence intervals (CIs) was used to report an outcome.Results: Among the 24 studies identified, 19 evaluated ARB as monotherapy, 4 evaluated ARB as combination therapy and one evaluated ARB both as monotherapy and combination therapy. Median (range) duration of the studies was 12 (1.84-54.0) months. ARB monotherapy significantly (p < 0.01) reduced BP (treatment ≥1 year: SBP [MD: -14.84 mmHg; 95% CI: -17.82 to -11.85]/DBP [-10.27 mmHg; -12.26 to -8.27]) and proteinuria (≥1 year [-0.90 g/L; -1.22 to -0.59]). Results were consistent for combination therapy. In these studies, non-significant changes were observed for eGFR, CrCl and SCr. The impact of SBP changes on eGFR was not significant; however, studies were of a relatively short duration.Conclusion: ARB had a favorable impact on BP and renal parameters such as proteinuria with monotherapy as well as with combination therapy, highlighting their potential benefits in patients with hypertension and CKD. During the short follow-up of these studies, no significant change in eGFR was observed.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Burnier M,Lin S,Ruilope L,Bader G,Durg S,Brunel Pdoi
10.1080/08037051.2019.1644155subject
Has Abstractpub_date
2019-12-01 00:00:00pages
358-374issue
6eissn
0803-7051issn
1651-1999journal_volume
28pub_type
杂志文章,meta分析相关文献
BLOOD PRESSURE文献大全abstract::Gestational hypertension is a recognized risk factor for the development of complications during pregnancy. The present study retrospectively assessed the respective values of blood pressure components derived from conventional and 24-h recordings (ABPM) as predictors of premature delivery in women with gestational hy...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050902836753
更新日期:2009-01-01 00:00:00
abstract::Home blood pressure monitoring (HBPM) is an easy and standardized tool to measure blood pressure (BP) at home, which is recommended by several national and international guidelines to obtain reliable BP values. It is a useful and dependable measure of BP, which can add information to the more common and standardized m...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037051.2015.1070599
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to determine the prevalence of Left ventricular hypertrophy (LVH) and different left ventricular (LV) geometric patterns in the middle-aged women population of Tallinn, to assess the relationship between LV geometry, age, blood pressure and LV repolarization duration and inhomogeneity....
journal_title:Blood pressure
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes mellitus or with general high cardiovascular (CV) risk. We addressed this issue by post-hoc analysing ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2020.1856642
更新日期:2021-01-06 00:00:00
abstract::We examined the influence of the Q89R variant in low-density lipoprotein receptor-related protein 5 on hypertension in a large Japanese cohort. We used multivariate logistic regression analysis to adjust for the effects of other factors known to influence hypertension such as age, body mass index, blood chemistry and ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050600650191
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Cerebral white matter lesions (WMLs) are regarded to be subclinical ischemic changes of the cerebral parenchyma. Many previous studies have shown that baseline blood pressure (BP) is one of the most important factors for WMLs, but the relation between exercise BP and WMLs has not been fully evaluated. So, we...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2018.1423544
更新日期:2018-06-01 00:00:00
abstract::Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.1080/08037050802677695
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The efficacy and safety of renin angiotensin aldosterone system blockers (RAASB's) if introduced immediately after renal transplantation have not been extensively investigated. METHODS:The medical charts of 142 kidney transplant recipients who received a RAASB in the early postoperative period and of 114 ma...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037051.2016.1182856
更新日期:2017-02-01 00:00:00
abstract::Ascending aortic blood pressure-derived indices were shown to be related to coronary atherosclerosis. However, no study so far has analyzed the relation between ascending aortic pulsatility and the extent of coronary atherosclerosis in normotensives. Therefore, the aim of the present analysis was to assess the relatio...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050701428125
更新日期:2007-01-01 00:00:00
abstract::To investigate the factors responsible for the morning rise in blood pressure (BP) in obstructive sleep apnea syndrome (OSAS) we examined a group of 253 consecutive snorers or OSAS patients. On the basis of their AHI the patients were classified in four groups. BP was measured on the evening before sleep onset and on ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077598
更新日期:1995-07-01 00:00:00
abstract::There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure. Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetyl...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.481808
更新日期:2010-06-01 00:00:00
abstract::Arterial hypertension is accompanied by increased morbidity and mortality and constitutes a substantial part of medical care. Antihypertensive intervention reduces the cardiovascular morbidity and mortality. The aims of the study were to evaluate the relationship between cardiovascular risk factors and the blood press...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050050151780
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To compare unattended blood pressure (BP) with two attended BP, with 24-h ambulatory (ABPM) and central BP measurements in hypertensive patients with (DMs) and without diabetes (HTs). METHODS:In the same hypertension clinic we evaluate 129 consecutive HTs (56% female, 59 + 16 yrs) and 91 DMs (62% female, 64 ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1568184
更新日期:2019-04-01 00:00:00
abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709061808
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate if young normotensive subjects with a familial history of essential hypertension (FHH) or young borderline-hypertensive (BHT) subjects have a defect endothelial function. METHODS:Fifteen young (26 +/- 4 years) healthy normotensive (115 +/- 8/71 +/- 6 mmHg) subjects with a FHH, 31 matched healt...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370502320779485
更新日期:2002-01-01 00:00:00
abstract::Medullipin I (Med I) is a vasodepressor prohormone which is continuously elaborated into the renal venous effluent (RVE) of isolated rat kidneys perfused under high pressure. We have improved the yield of Med I by substituting saline for the albumin perfusate previously reported; and considerably improved refinement b...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409102295
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Abnormal left ventricular (LV) geometric patterns, particularly concentric LV hypertrophy, are associated with a greater risk of hypertensive complications. The aim of this study was to investigate the association between LV myocardial performance index (LVMPI) and aortic distensibility (AD) with different L...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2013.778006
更新日期:2013-10-01 00:00:00
abstract:AIMS:Cardiovascular disease is the leading cause of mortality and morbidity in the western world and has reached epidemic proportions. The incidence of congestive heart failure (CHD) and hypertension is also rising rapidly in many of the affluent Arab nations and cardiovascular diseases continue to be a leading cause o...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310028462
更新日期:2004-01-01 00:00:00
abstract::Sleep disordered breathing has increasingly been recognised as a frequent cause of ill-health in the community. Moderate or severe forms of the most common condition, obstructive sleep apnea (OSA), occur in up to 12% of the adult male population. A substantial body of literature has been published on the potential rel...
journal_title:Blood pressure
pub_type: 杂志文章,评审
doi:10.3109/08037059309077548
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular syst...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037051.2018.1443391
更新日期:2018-08-01 00:00:00
abstract::Since there appear to be important interactions between mechanisms of salt-sensitive and carbohydrate-sensitive hypertension, the goal of this study was to evaluate the effects of greatly reducing dietary salt intake and removal of one kidney (to increase salt sensitivity) on the hemodynamic and metabolic responses to...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077589
更新日期:1995-05-01 00:00:00
abstract::The Hypertension and Diabetes Screening and Awareness (HYDRA) study is a cross-sectional point-prevalence study performed in September 2001; 45,125 primary care attendees were recruited from a representative nationwide sample of 1912 primary care practices in Germany. Around 42% of all patients presenting in these pra...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310030982
更新日期:2004-01-01 00:00:00
abstract::Prehypertension is associated with increased cardiovascular events. While the "tracking phenomenon" is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP tre...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2015.1121708
更新日期:2016-06-01 00:00:00
abstract::Using both in vitro and in vivo techniques, it has repeatedly been shown that endothelium-dependent vasodilation (EDV) is impaired in different forms of experimental hypertension (SHR, Dahl salt-sensitive rat, DOCA-salt rat and renovascular hypertension). EDV has also been found to be impaired in primary, as well as i...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500439362
更新日期:2000-01-01 00:00:00
abstract:AIMS:The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, nor...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037050903576726
更新日期:2010-08-01 00:00:00
abstract::The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the ap...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1156905
更新日期:2016-08-01 00:00:00
abstract::Sympathetic nerve activity is augmented by calcium-channel blocker treatment as a result of decreased blood pressure. Dihydropyridine calcium-channel blockers are divided into three different types. The purpose of the present study was to investigate whether treatment effects on hemodynamics, cardiac autonomic nerve a...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/08037051.2012.694200
更新日期:2012-12-01 00:00:00
abstract::An estimate of arterial compliance--the stroke volume/pulse pressure ratio (SV/PP)--was studied in 801 participants in the Tecumseh Blood Pressure Study, a population-based ongoing cardiovascular, epidemiological investigation. The subjects were normal young adults (mean age 30 +/- 5.6 years) and 373 were females. Car...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059209065121
更新日期:1992-05-01 00:00:00
abstract::Purpose: Previous studies that evaluated the prevalence of hypertension in Nigeria were either clinic based, non-standardized or did not include out-of-clinic blood pressure (BP) measurement. Materials and Methods: We selected a rural and an urban community in one state in each of the 6 geopolitical zones of Nigeria. ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1612706
更新日期:2019-08-01 00:00:00
abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037050802059092
更新日期:2008-01-01 00:00:00