Associations between gene polymorphisms of the apelin-APJ system and the risk of hypertension.

Abstract:

:The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the apelin (rs3115757, rs56204867 and rs3761581) and APJ (rs7119375 and rs9943582) genes were determined by the TaqMan® MGB probe method. For male patients, the frequencies of mutant alleles in the three apelin gene SNPs were significantly different between the hypertension and control groups (all p < 0.05), while no significant difference was obtained for frequencies of mutant alleles in the two APJ gene SNPs (p > 0.05). For females, the frequencies of mutant alleles in all five SNPs were not significantly different between the hypertension and control groups (all p > 0.05). After adjusting for several factors, the risk of developing hypertension increased significantly in patients, regardless of gender, carrying rs3115757-C, rs56204867-C or rs3761581-A allele (all p < 0.05). The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin rs3761581-apelin rs3115757-APJ rs7119375. In conclusion, gene polymorphisms of the apelin-APJ system are associated with susceptibility to hypertension.

journal_name

Blood Press

journal_title

Blood pressure

authors

Huang F,Zhu P,Huang Q,Yuan Y,Lin F,Li Q

doi

10.3109/08037051.2016.1156905

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

257-62

issue

4

eissn

0803-7051

issn

1651-1999

journal_volume

25

pub_type

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