Abstract:
:Having found that circulating adrenaline (AD) is selectively elevated in stroke-prone spontaneously hypertensive rats (SHRSP) compared with Wistar-Kyoto rats (WKY), we extended the comparison to include other normotensive and hypertensive rat strains. Aortic catheters were implanted in young (5-7 weeks) and old (7-9 months) WKY, Black-Hooded Wistar (BHW), Sprague Dawley (SD), spontaneously hypertensive rats (SHR) and SHRSP for repeated measurement of mean arterial pressure (MAP) and blood sampling under conscious resting conditions. In the young SHR and SHRSP, MAP was already significantly higher than in age-matched WKY but MAP in the SD rats was similar. Plasma AD was significantly higher in SHR and lower in SD rats when compared with WKY. There was no difference in plasma noradrenaline (NA) between strains at this age. At the older age, MAP was 40-60 mmHg higher in SHR and SHRSP than in WKY and BHW but was significantly lower in the SD strain. Circulating AD did not differ between the normotensive strains but was 3-4 times higher in the hypertensive strains. Plasma NA was elevated in SHR only. The acute reduction of MAP caused by ganglion blockade (an index of the sympathetically mediated component of resting blood pressure) was greater in SHR and SHRSP than in WKY at the older age only. However, the residual MAP after ganglion blockade was significantly higher in the hypertensive strains at both ages. Regression analysis showed that in the older rats, plasma AD was correlated with resting MAP, the reduction in MAP with ganglion blockade, the residual MAP and plasma NA.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Blood Pressjournal_title
Blood pressureauthors
Jablonskis LT,Howe PRdoi
10.3109/08037059409101529subject
Has Abstractpub_date
1994-03-01 00:00:00pages
106-11issue
1-2eissn
0803-7051issn
1651-1999journal_volume
3pub_type
杂志文章相关文献
BLOOD PRESSURE文献大全abstract::Ascending aortic blood pressure-derived indices were shown to be related to coronary atherosclerosis. However, no study so far has analyzed the relation between ascending aortic pulsatility and the extent of coronary atherosclerosis in normotensives. Therefore, the aim of the present analysis was to assess the relatio...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050701428125
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. METHODS:We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050500339275
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The most common ophthalmologic manifestation of hypertension is hypertensive retinopathy. Our study was designed to evaluate the factors that determine retinal vessel caliber in hypertensive subjects. METHODS:During a 6-month period, retinal photographs were taken of participants during a routine yearly che...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2012.645336
更新日期:2012-06-01 00:00:00
abstract::Losartan represent a novel approach in the treatment of hypertension. Clinical trials have reported a very low incidence of side effects. We describe two patients who developed increases in alanine/aspartate amino transferase of 8 and 15 times the upper normal limit, as well as thoracic pain, after a short time of tre...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609062128
更新日期:1996-05-01 00:00:00
abstract::The Hypertension and Diabetes Screening and Awareness (HYDRA) study is a cross-sectional point-prevalence study performed in September 2001; 45,125 primary care attendees were recruited from a representative nationwide sample of 1912 primary care practices in Germany. Around 42% of all patients presenting in these pra...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050310030982
更新日期:2004-01-01 00:00:00
abstract::Purpose: Arterial stiffness predicts cardiovascular complications. The association between arterial stiffness and blood lead (BL) remains poorly documented. We aimed to assess the association of central hemodynamic measurements, including pulse wave velocity (aPWV), with blood lead in a Flemish population.Materials an...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2019.1658518
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:Cerebral white matter lesions (WMLs) are regarded to be subclinical ischemic changes of the cerebral parenchyma. Many previous studies have shown that baseline blood pressure (BP) is one of the most important factors for WMLs, but the relation between exercise BP and WMLs has not been fully evaluated. So, we...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037051.2018.1423544
更新日期:2018-06-01 00:00:00
abstract:AIM:To describe the limitation of physical activity, the cause of limitation of physical activity and symptoms of dyspnea and chest pain before and 2 years after coronary artery bypass grafting (CABG) in relation to a history of hypertension. METHODS:All patients from western Sweden who underwent CABG between 1988 and...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709062094
更新日期:1997-11-01 00:00:00
abstract::It has previously been documented that patients with obstructive sleep apnoea (OSA) have an abnormal blood pressure (pressor) response to acute hypoxia when awake. The relationship between hypoxic chemosensitivity and 24 h blood pressure in OSA is not known. Twenty-four hour ambulatory BP (ABP) was measured at 15 min ...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101521
更新日期:1994-03-01 00:00:00
abstract::Since there appear to be important interactions between mechanisms of salt-sensitive and carbohydrate-sensitive hypertension, the goal of this study was to evaluate the effects of greatly reducing dietary salt intake and removal of one kidney (to increase salt sensitivity) on the hemodynamic and metabolic responses to...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059509077589
更新日期:1995-05-01 00:00:00
abstract::In a previous study we investigated the differential time courses of the vasodilator effect of various calcium antagonists (CA) in small isolated rat mesenteric arteries (van der Lee et al., Fundam Clin Pharmacol, 1998: 12: 607-12). We concluded that the differences observed could be due to differences in lipophilicit...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/08037050152669738
更新日期:2001-01-01 00:00:00
abstract::One-thousand-four-hundred-and-fifty-three patients admitted to a teaching hospital, haemodynamically stable and not severely ill nor in significant pain, were interviewed within 48 h of admission and demographic data and a detailed drinking history were obtained. Supine blood pressures (BP) were recorded on the day fo...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059709061808
更新日期:1997-03-01 00:00:00
abstract:AIMS:The aim of the study was to determine whether a high dose of atorvastatin lowers blood pressure (BP) in normolipemic patients with well controlled primary arterial hypertension and if this effect is associated with alteration of biomarkers of endothelial function and oxidative stress. In this open-label study, nor...
journal_title:Blood pressure
pub_type: 杂志文章,随机对照试验
doi:10.3109/08037050903576726
更新日期:2010-08-01 00:00:00
abstract::The BBB study (Swedish for Behandla Blodtryck Bättre or Treat Blood Pressure Better) was a multicenter trial designed to investigate three aspects of antihypertensive treatment: i) Is it possible to lower the diastolic blood pressure further in "well-treated" hypertensive patients through intensified therapy? ii) Can ...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/08037059409102265
更新日期:1994-07-01 00:00:00
abstract:UNLABELLED:Resistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance to antihypertensive treatment and cardiovascular complications. Biophysical forces within the arterial wall provide functional regulation of arterial stiffness. Caroti...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2011.617045
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To determine the clinical profile and blood pressure (BP) control rates of anticoagulated patients with hypertension and atrial fibrillation (AF). METHODS:The PAULA study was a multicenter cross-sectional/retrospective observational study conducted throughout Spain. The study included patients with nonvalvul...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037051.2017.1313094
更新日期:2017-10-01 00:00:00
abstract::Whole-body insulin sensitivity has been shown to be impaired in subjects with increased left ventricular relative wall thickness (RWT) and in hypertensive subjects with left ventricular hypertrophy, but the relation between myocardial insulin sensitivity and RWT or left ventricular mass index (LVMI) in normotension is...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.1080/080370501750183354
更新日期:2001-01-01 00:00:00
abstract::NORDIL--the Nordic Diltiazem Study (NORDIL)--is a prospective, randomized, open blinded-endpoint (PROBE), multicenter, parallel-group morbidity/mortality outcome study in hypertensive patients designed to compare an intervention strategy based on the calcium antagonist diltiazem with a strategy based on conventional a...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/080370599439517
更新日期:1999-01-01 00:00:00
abstract::The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the ap...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2016.1156905
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To determine the factors influencing general practitioners' prescribing for patients with moderate hypertension, and to investigate their ability to assess patients' absolute risk of cardiovascular disease. DESIGN:Decision-making was assessed by a postal questionnaire involving five standardised example pati...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/080370500300000897
更新日期:2000-01-01 00:00:00
abstract::Serotonin stimulates phospholipase A(2)(PLA(2)) leading to the production of prostaglandin products, several of which are vasoconstrictors. We hypothesised that the elevated vascular responsiveness to serotonin in deoxycorticosterone acetate (DOCA)-hypertensive rats is due in part to augmented production of vasoconstr...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609062117
更新日期:1996-03-01 00:00:00
abstract:AIMS:(1) To evaluate the prevalence of clinic blood pressure (BP) control in a large sample of treated hypertensives followed in our hypertension clinic during the year 2000, and to compare it with our 1997 data. (2) To investigate the prevalence of left ventricular hypertrophy (LVH) according to different levels of BP...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.1080/08037050213762
更新日期:2002-01-01 00:00:00
abstract::In order to study the contribution of the nitric oxide (NO)-pathway to cholinergic vasodilatation in the resistance vessels of the human forearm, we infused acetylcholine (ACh; 0.1 1000 ng/kg/min) or methacholine (MCh; 0.1 A 100 ng/kg/min) in the presence of saline, the NO-scavenger and guanylate cyclase inhibitor met...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059609078071
更新日期:1996-11-01 00:00:00
abstract::The microvasculature and macrovasculature undergo extensive, organ-specific perinatal maturation. Multiple studies show associations between low birth weight and subsequent cardiovascular dysfunction in adulthood, suggesting that extreme preterm birth interferes with this maturation process. Therefore, we designed PRE...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章
doi:10.3109/08037051.2015.1053220
更新日期:2015-01-01 00:00:00
abstract::In this study we aimed to elucidate the role of central noradrenergic, dopaminergic, adrenergic and serotonergic neuronal systems in the development of essential hypertension. Fifteen untreated essential hypertensive subjects (aged 44 +/- 3 years) and 32 healthy volunteers (aged 38 +/- 3 years) participated in this st...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037059409101522
更新日期:1994-03-01 00:00:00
abstract::There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure. Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetyl...
journal_title:Blood pressure
pub_type: 杂志文章
doi:10.3109/08037051.2010.481808
更新日期:2010-06-01 00:00:00
abstract::The HEART project was conducted in general practice to determine whether lifestyle strategies, aimed at increasing physical activity and dietary modification, can be substituted for drug therapy in patients who have been well controlled on antihypertensive medication. In addition to blood pressure (BP) and risk factor...
journal_title:Blood pressure
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/080370500448650
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The main objective was to compare the mean change in augmentation index of hypertensive patients treated with nebivolol or atenolol. METHODS:Multicenter, double-blind randomized study conducted in six Spanish centers. We enrolled outpatients between the ages of 40 and 65 years with mild or moderate essent...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/08037051.2013.840421
更新日期:2014-06-01 00:00:00
abstract::Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or withou...
journal_title:Blood pressure
pub_type: 杂志文章,meta分析
doi:10.1080/08037051.2019.1644155
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Detection and treatment of left ventricular hypertrophy (LVH) in hypertension is important in order to reduce cardiovascular risk. The product of QRS voltage and duration (e.g. Cornell voltage-duration product; CorP), is a good marker of LVH and the current study was designed to determine the prevalence of...
journal_title:Blood pressure
pub_type: 杂志文章,多中心研究
doi:10.1080/08037050802059092
更新日期:2008-01-01 00:00:00