Abstract:
:Medullipin I (Med I) is a vasodepressor prohormone which is continuously elaborated into the renal venous effluent (RVE) of isolated rat kidneys perfused under high pressure. We have improved the yield of Med I by substituting saline for the albumin perfusate previously reported; and considerably improved refinement by directly fractionating the crude lipid extract of the RVE with high pressure liquid chromatography. The results show that Med I, as defined by previous physiologic and pharmacologic criteria, is not a single molecule. The 3 Class I medullipins described here are distinguished by subtle or overt differences in polarity and biologic activity.
journal_name
Blood Pressjournal_title
Blood pressureauthors
Brooks B,Byers LW,Muirhead EE,Muirhead M,Pitcock JA,Maddipati KR,Maxey KMdoi
10.3109/08037059409102295subject
Has Abstractpub_date
1994-11-01 00:00:00pages
407-17issue
6eissn
0803-7051issn
1651-1999journal_volume
3pub_type
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