Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats.

abstract：BACKGROUND:Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. OBJECTIVES:To systematically review randomized and quasi-random...

journal_title：Neonatology

authors： Neumann R,Schulzke SM,Bührer C

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Oxidative stress in the newborn period may cause cell injury and inflammation if the antioxidant capacity is insufficient. To monitor antioxidant and inflammatory activity we examined by in vivo imaging various strains of luciferase reporter mice whose light-emitting properties were regulated by response e...

journal_title：Neonatology

authors： Dohlen G,Odland HH,Carlsen H,Blomhoff R,Thaulow E,Saugstad OD

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. OBJECTIVE:To study the relationship between birth weight and b...

journal_title：Neonatology

authors： Smal JC,Uiterwaal CS,Bruinse HW,Steendijk P,van Bel F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Cardiac troponin T (cTnT) has been proposed as specific biochemical marker for myocardial infarction in adults. Cardiac function in neonates could be influenced by the severity of respiratory distress and its ventilatory management. OBJECTIVES:To establish a normal range of cTnT in healthy neonates, compare...

journal_title：Neonatology

authors： Awada H,Al-Tannir M,Ziade MF,Alameh J,El Rajab M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...

journal_title：Neonatology

authors： Weisz DE,Jain A,McNamara PJ,EL-Khuffash A

更新日期：2012-01-01 00:00:00

abstract：:Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the updated recommendations of a European panel of expert neonatologists who had developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. T...

journal_title：Neonatology

authors： Sweet DG,Carnielli V,Greisen G,Hallman M,Ozek E,Plavka R,Saugstad OD,Simeoni U,Speer CP,Halliday HL,European Association of Perinatal Medicine.

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The probabilities of survival and survival without major brain damage (MBD) are low in newborns at the limit of viability. Survival without MBD constitutes a major concern for parents and professionals. OBJECTIVES:To know the probabilities of survival without MBD in newborns ≤26 weeks' gestational age (GA) ...

journal_title：Neonatology

authors： García-Muñoz Rodrigo F,Urquía Martí L,García Hernández JÁ,Figueras Aloy J,García-Alix Pérez A,SEN1500 Network of the Spanish Neonatal Society.

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. OBJECTIVE:This study aims to estimate the incidence of NEC in a large cohort of ...

journal_title：Neonatology

authors： Ree IM,Smits-Wintjens VE,Rijntjes-Jacobs EG,Pelsma IC,Steggerda SJ,Walther FJ,Lopriore E

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Closed endotracheal suction interferes with mechanical ventilation received by infants, but the change to ventilation may be different when ventilator modes that target expired tidal volume (VT(e)) are used. OBJECTIVE:To measure airway pressure and tidal volume distal to the endotracheal tube (ETT) during a...

journal_title：Neonatology

authors： Kiraly NJ,Tingay DG,Mills JF,Dargaville PA,Copnell B

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Endogenous carbon monoxide (CO) production is primarily due to heme degradation, which also results in the equimolar production of bilirubin. Thus, estimates of total body CO production can serve as indices of total body bilirubin formation. The elimination rate of CO from a person's body (CO washout rate) a...

journal_title：Neonatology

authors： Stevenson DK,Wong RJ,Ostrander CR,Maric I,Vreman HJ,Cohen RS

更新日期：2020-01-01 00:00:00

abstract：:Treatment of sick neonates originated in maternity and foundling hospitals in the 19th century. Nosocomial infections and difficult logistics of wet-nursing prevented admission of neonates in most children's hospitals well into the 20th century. In this article, 31 hospitals are described, all located in large cities,...

journal_title：Neonatology

authors： Obladen M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Retinopathy of prematurity (ROP) is a sight-threatening disease affecting extremely preterm infants. The introduction of new ROP screening surveillance systems, with higher sensitivity and specificity than established ROP screening guidelines, has the potential to reduce the number of stressful eye examinati...

journal_title：Neonatology

authors： Lundgren P,Stoltz Sjöström E,Domellöf M,Smith L,Wu C,VanderVeen D,Hellström A,Löfqvist C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Neonatal reference values of gallbladder size have been assessed in healthy newborns with enteral feeding regimen. Their applicability to critically ill patients under total parenteral nutrition (TPN) remains to be questioned. OBJECTIVE:Our aim was to evaluate the impact of short-term TPN versus enteral nut...

journal_title：Neonatology

authors： Schmidt B,Roth B,Stützer H,Benz-Bohm G

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Schistocytes are circulating erythrocyte fragments. They can be identified microscopically from a blood smear; but automated systems evaluate more cells and avoid inconsistencies in microscopy. Studies using adult subjects indicate that automated quantification of schistocytes can be clinically useful. Howev...

journal_title：Neonatology

authors： Judkins AJ,MacQueen BC,Christensen RD,Henry E,Snow GL,Bennett ST

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. OBJECTIVES:This research aimed to (1) describe var...

journal_title：Neonatology

authors： McCloskey K,De Livera AM,Collier F,Ponsonby AL,Carlin JB,Vuillermin P,Mellett NA,Jayawardana K,Weir JM,Blangero J,Curran JE,Burgner D,Meikle PJ,BIS investigator group.

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth. OBJECTIVES:To study the inflammatory, structural and functional effects of caffeine in an animal mode...

journal_title：Neonatology

authors： Nagatomo T,Jiménez J,Richter J,De Baere S,Vanoirbeek J,Naulaers G,Allegaert K,Croubels S,Deprest JA,Toelen J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Higher patient-to-nurse ratios and nursing workload are associated with increased mortality in the adult intensive care unit (ICU). Most neonatal ICUs (NICUs) in the United Kingdom do not meet national staffing recommendations. The impact of staffing on outcomes in the NICU is unknown. OBJECTIVE:To determin...

journal_title：Neonatology

authors： Sherenian M,Profit J,Schmidt B,Suh S,Xiao R,Zupancic JA,DeMauro SB

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. OBJECTIVES:To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. M...

journal_title：Neonatology

authors： Doyle LW,Ehrenkranz RA,Halliday HL

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Eye drop treatment routinely used to obtain mydriasis prior to fundoscopy in neonates requires repeated instillations of mydriatic agents that can lead to systemic side effects. OBJECTIVES:The aim of this study was to compare the mydriatic efficacy and tolerance of administration of phenylephrine and tropic...

journal_title：Neonatology

authors： Bremond-Gignac D,Jacqz-Aigrain E,Abdoul H,Daruich A,Beresniak A,Baud O,Alberti C,on behalf of the CLAIR FO Study Group.

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:High-dose dexamethasone (DXM) treatment of preterms at risk of bronchopulmonary dysplasia leads to a deterioration in quality of their general movements (GMs). It is unknown whether low-dose DXM affects GM quality similarly. OBJECTIVES:To assess the effect of low-dose DXM treatment on the quality of GMs and...

journal_title：Neonatology

authors： Hitzert MM,Roescher AM,Bos AF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Ventilatory pressures should target the range between the upper and lower inflection point of the pressure volume curve in order to avoid atelecto- and volutrauma. During high-frequency oscillatory ventilation (HFOV), this range is difficult to determine. Quadrant impedance measurement (QIM) has recently bee...

journal_title：Neonatology

authors： Burkhardt W,Kurth F,Pitterle M,Blassnig N,Wemhöner A,Rüdiger M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Premature birth is a significant health care burden. Xenon (Xe) is a general anesthetic with neuroprotective effects. OBJECTIVES:Here, we investigate the neuroprotective role of Xe in a lipopolysaccharide (LPS)- and hypoxia-ischemia (HI)-induced white matter damage (WMD) model. METHODS:Three-day-old Spragu...

journal_title：Neonatology

authors： Yin X,Zhao J,Jiang H,Li L,Jiang J,Xi H,Peng X,Yin X,Shi X,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:Transcutaneous electromyography of the diaphragm (dEMG) is a noninvasive and easy applicable tool to measure the electrical activity of the diaphragm. dEMG monitoring has recently been introduced in the neonatal intensive care unit as a novel cardiorespiratory monitor providing direct information on diaphragmatic brea...

journal_title：Neonatology

authors： Kraaijenga JV,Hutten GJ,de Jongh FH,van Kaam AH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The postnatal heart responds to biomechanical stress with hypertrophy. The fetal heart may also undergo hyperplasia, but the percentage of mitotically active cardiomyocytes decreases throughout gestation. The signaling pathways controlling growth and proliferation in the fetal heart are poorly understood. O...

journal_title：Neonatology

authors： Olson AK,Protheroe KN,Scholz TD,Segar JL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Numerous studies in cultured cells indicate that damage to mitochondrial DNA (mtDNA) dictates cellular responses to oxidant stress, yet the consequences of mtDNA damage have not been studied directly in the preterm lung. OBJECTIVE:We sought to determine whether hyperoxia-induced fetal lung dysmorphogenesis ...

journal_title：Neonatology

authors： Gebb SA,Decoux A,Waggoner A,Wilson GL,Gillespie MN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Sustained lung inflation (SLI) applied at birth has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity in animal studies. OBJECTIVES:To verify if the application of SLI in preterm infants at birth may reduce the need for mechanical ventilation a...

journal_title：Neonatology

authors： Lista G,Fontana P,Castoldi F,Cavigioli F,Dani C

更新日期：2011-01-01 00:00:00

abstract：:The aim of this article is to educate neonatal caregivers about metagenomics. This scientific field uses novel and ever changing molecular methods to identify how infants become colonized with microbes after birth. Publications using metagenomics appear infrequently in the neonatal literature because clinicians are un...

journal_title：Neonatology

authors： Sherman MP,Minnerly J,Curtiss W,Rangwala S,Kelley ST

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The clinical significance of early transient hypoglycemia (ETH), a frequent event in preterm newborns, is a highly controversial issue. In experimental models, hypoglycemia has been reported to cause oxidative stress. Among the reactive species, early generated peroxynitrite is responsible for protein nitrat...

journal_title：Neonatology

authors： Wayenberg JL,Cavedon C,Ghaddhab C,Lefèvre N,Bottari SP

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Recent studies indicate an increasing use of less invasive surfactant administration. Different techniques have been shown with distinct risks and benefits. The aim of this study was to develop a new method that simplifies this procedure. OBJECTIVES:An applicator was developed and tested on a manikin to mak...

journal_title：Neonatology

authors： Maiwald CA,Neuberger P,Vochem M,Poets C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. OBJECTIVE:To evaluate the effect of phenob...

journal_title：Neonatology

authors： Deshpande P,Jain A,McNamara PJ

更新日期：2021-01-07 00:00:00