Activation of the mitogen-activated protein kinases and Akt in response to pulmonary artery banding in the fetal sheep heart is developmentally regulated.

Abstract:

BACKGROUND:The postnatal heart responds to biomechanical stress with hypertrophy. The fetal heart may also undergo hyperplasia, but the percentage of mitotically active cardiomyocytes decreases throughout gestation. The signaling pathways controlling growth and proliferation in the fetal heart are poorly understood. OBJECTIVE:To determine whether activation of the mitogen-activated protein kinases and Akt in the acute response to pressure loading in the fetal heart is developmentally regulated. METHODS:Pulmonary artery banding (PAB) was performed in 100- or 128-day fetuses of twin gestation (n = 6 per group) for 6 h. One twin served as a control. Right ventricular (RV) and left ventricular (LV) mitogen-activated protein kinase, Akt, and cyclin D1 protein levels were determined by Western blot. RESULTS:Within each gestational age group, hemodynamic and arterial blood gas values were similar between PAB and control fetuses. The total mitogen-activated protein kinase and Akt protein levels were unchanged by PAB at both gestational ages, as were active p38 and JNK levels. The RV levels of active ERK tended to decrease in 128-day PAB fetuses as compared with controls, and LV active ERK normalized to total ERK was significantly decreased. At gestational age (GA) 100 days, RV active ERK levels were significantly higher in PAB animals as compared with controls, with a trend towards increased active Akt levels. No differences were seen in the 100-day LV. The levels of the cell cycle promoter cyclin D1 were unchanged in all animals. CONCLUSIONS:Pressure loading of the fetal sheep heart leads to developmentally regulated cell signaling profiles. ERK and possibly Akt may be important regulators of in vivo cardiomyocyte hyperplasia.

journal_name

Neonatology

journal_title

Neonatology

authors

Olson AK,Protheroe KN,Scholz TD,Segar JL

doi

10.1159/000107729

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

145-52

issue

3

eissn

1661-7800

issn

1661-7819

pii

000107729

journal_volume

93

pub_type

杂志文章
  • Doppler-assessed cerebral blood flow velocity in the neonate as estimator of global cerebral blood volume flow measured using phase-contrast magnetic resonance angiography.

    abstract:BACKGROUND:We hypothesized that color Doppler-measured cerebral blood flow velocity (CD-CBFV) as measured in the three feeding arteries of the brain can be used as an estimator of global cerebral blood flow. PATIENTS AND METHODS:CD-CBFV was determined as soon as possible after determination of phase-contrast magnetic ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000342336

    authors: Benders MJ,Hendrikse J,de Vries L,Groenendaal F,van Bel F

    更新日期:2013-01-01 00:00:00

  • Melatonin levels during the first week of life and their relation with the antioxidant response in the perinatal period.

    abstract:AIM:Melatonin is a potent free radical scavenger and an indirect antioxidant. Knowledge about the behavior of melatonin secretion in the early neonatal period, which may relate to its properties at a vital stage during very high antioxidant demands, is limited. PATIENTS AND METHODS:We studied 35 newborns admitted to t...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000102957

    authors: Muñoz-Hoyos A,Bonillo-Perales A,Avila-Villegas R,González-Ripoll M,Uberos J,Florido-Navío J,Molina-Carballo A

    更新日期:2007-01-01 00:00:00

  • Variability in the assessment of 'adequate' chest excursion during simulated neonatal resuscitation.

    abstract:BACKGROUND:International neonatal resuscitation guidelines recommend assessing chest excursion when the heart rate is not improving. However, the accuracy in assessing 'adequate' chest excursion lacks objectivity. AIM:It was the aim of this study to test the accuracy in the assessment of 'adequate' chest excursion by ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000322009

    authors: Brugada M,Schilleman K,Witlox RS,Walther FJ,Vento M,Te Pas AB

    更新日期:2011-01-01 00:00:00

  • Neurodevelopmental Outcomes in Preterm Infants with White Matter Injury Using a New MRI Classification.

    abstract:OBJECTIVE:The aim of this study was to evaluate whether a new MRI scoring system for preterm non-haemorrhagic white matter injury (WMI), derived from the analysis of the natural evolution of WMI throughout the neonatal period until term-equivalent age, can be used for outcome prediction. METHODS:Eighty-two infants <36...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000499346

    authors: Martinez-Biarge M,Groenendaal F,Kersbergen KJ,Benders MJNL,Foti F,van Haastert IC,Cowan FM,de Vries LS

    更新日期:2019-01-01 00:00:00

  • Influence of prematurity on postnatal maturation of heart rate and arterial pressure responses to hypoxia in lambs.

    abstract:BACKGROUND:While hypoxic events with bradycardias are a frequent occurrence during the first weeks of life in preterm infants, the impact of preterm birth on maturation of the cardiovascular response to hypoxia in early postnatal life is unknown. OBJECTIVES:In the present study, we tested the hypothesis that preterm b...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000110868

    authors: Pladys P,Arsenault J,Reix P,Rouillard Lafond J,Moreau-Bussière F,Praud JP

    更新日期:2008-01-01 00:00:00

  • Expression of Transcription Factor GATA-6 in Alveolar Epithelial Cells Is Linked to Neonatal Lung Disease.

    abstract:BACKGROUND:Premature birth and respiratory distress syndrome (RDS) are risk factors for disturbed lung development and bronchopulmonary dysplasia (BPD). The molecular mechanisms related to prematurity and BPD remain largely unknown. Epithelial expression of the transcription factor GATA-6 has been implicated in normal ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000317827

    authors: Vähätalo R,Asikainen TM,Karikoski R,Kinnula VL,White CW,Andersson S,Heikinheimo M,Myllärniemi M

    更新日期:2011-01-01 00:00:00

  • Automated Quantification of Fragmented Red Blood Cells: Neonatal Reference Intervals and Clinical Disorders of Neonatal Intensive Care Unit Patients with High Values.

    abstract:BACKGROUND:Schistocytes are circulating erythrocyte fragments. They can be identified microscopically from a blood smear; but automated systems evaluate more cells and avoid inconsistencies in microscopy. Studies using adult subjects indicate that automated quantification of schistocytes can be clinically useful. Howev...

    journal_title:Neonatology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000491626

    authors: Judkins AJ,MacQueen BC,Christensen RD,Henry E,Snow GL,Bennett ST

    更新日期:2019-01-01 00:00:00

  • Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats.

    abstract:BACKGROUND:Extreme hyperbilirubinemia is treated with double volume exchange transfusion, which may take hours to commence. A neuroprotective agent that could be administered immediately might be clinically useful. Minocycline, an anti-inflammatory and anti-apoptotic semisynthetic tetracycline, prevents hyperbilirubine...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000103740

    authors: Geiger AS,Rice AC,Shapiro SM

    更新日期:2007-01-01 00:00:00

  • Assessment of Risk Indicators for Targeted Cytomegalovirus Screening in Neonates.

    abstract:BACKGROUND:In the absence of universal screening for congenital cytomegalovirus (cCMV) infection, the aim of this study was to assess the outcomes of a targeted screening protocol based on maternal and neonatal risk indicators. METHODS:The medical records of 2,623 neonates born in our maternal hospital between June 20...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000512525

    authors: Levit Y,Dym L,Yochpaz S,Manor Y,Adler A,Halutz O,Grisaru-Soen G,Herzlich J,Marom R

    更新日期:2020-12-22 00:00:00

  • Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years.

    abstract:BACKGROUND:Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES:Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS:We randomly...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000489389

    authors: Ku MS

    更新日期:2018-01-01 00:00:00

  • Secretoneurin Serum Levels in Healthy Term Neonates and Neonates with Hypoxic-Ischaemic Encephalopathy.

    abstract:BACKGROUND:Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge of brain injury is important to guide therapeutic decisions and reliably inform the parents. Increased secretoneurin levels have been detected in adult patients suffering from brain injury an...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000444245

    authors: Wechselberger K,Schmid A,Posod A,Höck M,Neubauer V,Fischer-Colbrie R,Kiechl-Kohlendorfer U,Griesmaier E

    更新日期:2016-01-01 00:00:00

  • Newborn Resuscitation Training Programmes Reduce Early Neonatal Mortality.

    abstract:BACKGROUND:Substantial health care resources are expended on standardised formal neonatal resuscitation training (SFNRT) programmes, but their effectiveness has not been proven. OBJECTIVES:To determine whether SFNRT programmes reduce neonatal mortality and morbidity, improve acquisition and retention of knowledge and ...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000443875

    authors: Pammi M,Dempsey EM,Ryan CA,Barrington KJ

    更新日期:2016-01-01 00:00:00

  • Survey of practices regarding utilization of inhaled steroids in 223 German neonatal units.

    abstract:BACKGROUND:No survey has been published in recent years which primarily focuses on the prescription of inhaled corticosteroids in neonatal practice. Thus, the utilization rate of inhaled corticosteroids is unknown. OBJECTIVES:To elucidate the current utilization rate of inhaled corticosteroids in the prevention and th...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000316978

    authors: Maas C,Poets CF,Bassler D

    更新日期:2010-01-01 00:00:00

  • Social Birth: Rites of Passage for the Newborn.

    abstract::Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewi...

    journal_title:Neonatology

    pub_type: 历史文章,杂志文章

    doi:10.1159/000477955

    authors: Obladen M

    更新日期:2017-01-01 00:00:00

  • Continuous noninvasive monitoring of lung recruitment during high-frequency oscillatory ventilation by electrical impedance measurement: an animal study.

    abstract:BACKGROUND:Ventilatory pressures should target the range between the upper and lower inflection point of the pressure volume curve in order to avoid atelecto- and volutrauma. During high-frequency oscillatory ventilation (HFOV), this range is difficult to determine. Quadrant impedance measurement (QIM) has recently bee...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000345612

    authors: Burkhardt W,Kurth F,Pitterle M,Blassnig N,Wemhöner A,Rüdiger M

    更新日期:2013-01-01 00:00:00

  • Molecular studies of an impetigo bullosa epidemic in full-term infants.

    abstract:BACKGROUND:Carriers of Staphylococcus aureus strains can be the source of epidemic infection for patients. OBJECTIVES:A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes of subsequent spreadi...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000204961

    authors: Jursa-Kulesza J,Kordek A,Kopron K,Wojciuk B,Giedrys-Kalemba S

    更新日期:2009-01-01 00:00:00

  • The quality of general movements after treatment with low-dose dexamethasone in preterm infants at risk of bronchopulmonary dysplasia.

    abstract:BACKGROUND:High-dose dexamethasone (DXM) treatment of preterms at risk of bronchopulmonary dysplasia leads to a deterioration in quality of their general movements (GMs). It is unknown whether low-dose DXM affects GM quality similarly. OBJECTIVES:To assess the effect of low-dose DXM treatment on the quality of GMs and...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000362919

    authors: Hitzert MM,Roescher AM,Bos AF

    更新日期:2014-01-01 00:00:00

  • The use of the WINROP screening algorithm for the prediction of retinopathy of prematurity in a Chinese population.

    abstract:BACKGROUND:Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. OBJECTIVE:To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. METHODS:...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000351297

    authors: Sun H,Kang W,Cheng X,Chen C,Xiong H,Guo J,Zhou C,Zhang Y,Hellström A,Löfqvist C,Zhu C

    更新日期:2013-01-01 00:00:00

  • Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.

    abstract:BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000261018

    authors: Rajatapiti P,de Rooij JD,Beurskens LW,Keijzer R,Tibboel D,Rottier RJ,de Krijger RR

    更新日期:2010-06-01 00:00:00

  • Restricted Ventilation Associated with Reduced Neurodevelopmental Impairment in Preterm Infants.

    abstract:BACKGROUND AND OBJECTIVE:Restrictive use of invasive mechanical ventilation (IMV) in preterm infants reduces the risk of bronchopulmonary dysplasia (BPD). Our objective was to determine its effect on neurodevelopmental impairment (NDI) at 24 months' corrected age (CA). METHODS:This retrospective single-center cohort s...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000471841

    authors: Vliegenthart RJS,Onland W,van Wassenaer-Leemhuis AG,De Jaegere APM,Aarnoudse-Moens CSH,van Kaam AH

    更新日期:2017-01-01 00:00:00

  • Less Neutrophil Extracellular Trap Formation in Term Newborns than in Adults.

    abstract:BACKGROUND:Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens. NETs may play an important role in the innate immune system and, thus...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000452615

    authors: Lipp P,Ruhnau J,Lange A,Vogelgesang A,Dressel A,Heckmann M

    更新日期:2017-01-01 00:00:00

  • The Use of Peritoneal Dialysis in Phenobarbitone Toxicity in a Critically Unwell Neonate.

    abstract:BACKGROUND:Phenobarbitone (PB) is the first-line anti-convulsant for neonatal seizures. The use of peritoneal dialysis (PD) to enhance drug elimination in cases of neonatal PB overdose has not been reported. OBJECTIVE:To report a case of neonatal severe PB toxicity and review the elimination of PB by PD. METHODS:Asse...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000481879

    authors: Le Page AK,Stewart AE,Roehr CC,Johnstone LM,Graudins A

    更新日期:2018-01-01 00:00:00

  • QuickSF: A New Technique in Surfactant Administration.

    abstract:BACKGROUND:Recent studies indicate an increasing use of less invasive surfactant administration. Different techniques have been shown with distinct risks and benefits. The aim of this study was to develop a new method that simplifies this procedure. OBJECTIVES:An applicator was developed and tested on a manikin to mak...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000450823

    authors: Maiwald CA,Neuberger P,Vochem M,Poets C

    更新日期:2017-01-01 00:00:00

  • Quantification of Hox and surfactant protein-B transcription during murine lung development.

    abstract:BACKGROUND:Genetic processes underlying fetal lung development and maturation are incompletely understood. Better knowledge of these processes would provide insights into the causes of lung malformations and prevention of respiratory distress syndrome and the potential adverse effects of glucocorticoids. Hox genes are ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000201739

    authors: Grier DG,Thompson A,Lappin TR,Halliday HL

    更新日期:2009-01-01 00:00:00

  • The Relationship between Oxidative Stress, Intermittent Hypoxemia, and Hospital Duration in Moderate Preterm Infants.

    abstract:INTRODUCTION:Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels of lipid peroxidation products and increased intermittent hypoxemia (IH) events have been associated with adverse outcomes in extremely preterm infants. ...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000509038

    authors: Shah VP,Raffay TM,Martin RJ,Vento M,Sánchez-Illana Á,Piñeiro-Ramos JD,Kuligowski J,Di Fiore JM

    更新日期:2020-01-01 00:00:00

  • Body Composition in Very Preterm Infants: Role of Neonatal Characteristics and Nutrition in Achieving Growth Similar to Term Infants.

    abstract:BACKGROUND:The identification of factors involved in the postnatal growth of preterm infants will help achieve growth similar to that of term infants. OBJECTIVES:As per protocol: to compare body composition in very preterm infants at term-corrected age (TCA) with that in term infants, and to explore relationships betw...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000450882

    authors: Tremblay G,Boudreau C,Bélanger S,St-Onge O,Pronovost E,Simonyan D,Marc I

    更新日期:2017-01-01 00:00:00

  • Volume-targeted versus pressure-limited ventilation for preterm infants: a systematic review and meta-analysis.

    abstract:BACKGROUND:The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. OBJECTIVES:To ...

    journal_title:Neonatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000326080

    authors: Wheeler KI,Klingenberg C,Morley CJ,Davis PG

    更新日期:2011-01-01 00:00:00

  • Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants.

    abstract:BACKGROUND:Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. OBJECTIVES:This research aimed to (1) describe var...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000487506

    authors: McCloskey K,De Livera AM,Collier F,Ponsonby AL,Carlin JB,Vuillermin P,Mellett NA,Jayawardana K,Weir JM,Blangero J,Curran JE,Burgner D,Meikle PJ,BIS investigator group.

    更新日期:2018-01-01 00:00:00

  • Effect of Phenobarbitone on Amplitude-Integrated Electroencephalography in Neonates with Hypoxic-Ischemic Encephalopathy during Hypothermia.

    abstract:BACKGROUND:Phenobarbitone induces suppression of cerebral electrical activity on amplitude-integrated electroencephalography (aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE); however, its effect during therapeutic hypothermia (TH) has not been well characterized. OBJECTIVE:To evaluate the effect of phenob...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000511540

    authors: Deshpande P,Jain A,McNamara PJ

    更新日期:2021-01-07 00:00:00

  • Optimal techniques for mRNA extraction from neonatal salivary supernatant.

    abstract:BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...

    journal_title:Neonatology

    pub_type: 杂志文章

    doi:10.1159/000328026

    authors: Dietz JA,Johnson KL,Wick HC,Bianchi DW,Maron JL

    更新日期:2012-01-01 00:00:00