Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development.

abstract：:Knotted-like (KNOX) proteins constitute a group of homeodomain proteins involved in pattern formation in developing tissues of angiosperms and other green plants. We conducted phylogenetic analyses of nucleotide and amino acid sequences of all known KNOX proteins in order to examine their evolution. Our analyses revea...

journal_title：Molecular biology and evolution

authors： Bharathan G,Janssen BJ,Kellogg EA,Sinha N

更新日期：1999-04-01 00:00:00

abstract：:A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserved exon-intron patt...

journal_title：Molecular biology and evolution

authors： Ragg H,Lokot T,Kamp PB,Atchley WR,Dress A

更新日期：2001-04-01 00:00:00

abstract：:Two recent studies have presented conflicting views on variation present within the 294 base third domain of the 12S rRNA gene in the genus Drosophila, and in D. pseudoobscura in particular. One study suggested that this gene is highly invariant across the genus, while another recovered 22 distinct haplotypes from 22 ...

journal_title：Molecular biology and evolution

authors： Noor MA,Larkin JC

更新日期：2000-06-01 00:00:00

abstract：:We carried out an in silico analysis of the complete genome sequences of 14 species, including eukaryotes, prokaryotes, and archaea, to investigate the proportion of amplified fragment length polymorphism bands that are homoplasious for the different species, as well as the distribution of fragment lengths. We investi...

journal_title：Molecular biology and evolution

authors： Caballero A,Quesada H

更新日期：2010-05-01 00:00:00

abstract：:Partial and complete genome duplications occurred during evolution and resulted in the creation of new genes and gene families. We identified a novel and intricate human gene family located primarily in regions of segmental duplications on human chromosome 1. We named it NBPF, for neuroblastoma breakpoint family, beca...

journal_title：Molecular biology and evolution

authors： Vandepoele K,Van Roy N,Staes K,Speleman F,van Roy F

更新日期：2005-11-01 00:00:00

abstract：:One challenge of analyzing samples of DNA sequences is to account for the nonnegligible polymorphisms produced by error when the sequencing error rate is high or the sample size is large. Specifically, those artificial sequence variations will bias the observed single nucleotide polymorphism (SNP) frequency spectrum, ...

journal_title：Molecular biology and evolution

authors： Liu X,Maxwell TJ,Boerwinkle E,Fu YX

更新日期：2009-07-01 00:00:00

abstract：:Quercus petraea and Quercus robur are two closely related oak species that frequently hybridize. We sequenced 70 clones containing the 5.8S and ITS2 regions of ribosomal DNA (rDNA) from these two species and did not detect a species-specific difference. Surprisingly, three divergent (up to 12.6%) rDNA families were id...

journal_title：Molecular biology and evolution

authors： Muir G,Fleming CC,Schlötterer C

更新日期：2001-02-01 00:00:00

abstract：:For populations to maintain optimal fitness, harmful mutations must be efficiently purged from the genome. Yet, under circumstances that diminish the effectiveness of natural selection, such as the process of plant and animal domestication, deleterious mutations are predicted to accumulate. Here, we compared the load ...

journal_title：Molecular biology and evolution

authors： Renaut S,Rieseberg LH

更新日期：2015-09-01 00:00:00

abstract：:Molar content of guanine plus cytosine (G + C) and optimal growth temperature (OGT) are main factors characterizing the frequency distribution of amino acids in prokaryotes. Previous work, using multivariate exploratory methods, has emphasized ascertainment of biological factors underlying variability between genomes,...

journal_title：Molecular biology and evolution

authors： Naya H,Gianola D,Romero H,Urioste JI,Musto H

更新日期：2006-01-01 00:00:00

abstract：:To explore the origin of the diversity observed in natural populations, many studies have investigated the relationship between genotype and phenotype. In yeast species, especially in Saccharomyces cerevisiae, these studies are mainly conducted using recombinant offspring derived from two genetically diverse isolates,...

journal_title：Molecular biology and evolution

authors： Brion C,Caradec C,Pflieger D,Friedrich A,Schacherer J

更新日期：2020-09-01 00:00:00

abstract：:Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are ubiquitous human pathogens. Both viruses evolved from simplex viruses infecting African primates and they are thus thought to have left Africa during early human migrations. We analyzed the population structure of HSV-1 and HSV-2 circulating strains. Results ind...

journal_title：Molecular biology and evolution

authors： Forni D,Pontremoli C,Clerici M,Pozzoli U,Cagliani R,Sironi M

更新日期：2020-05-01 00:00:00

abstract：:Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mutation load. We examine here if artificial selection can counteract the negative...

journal_title：Molecular biology and evolution

authors： Bosshard L,Peischl S,Ackermann M,Excoffier L

更新日期：2019-10-01 00:00:00

abstract：:Accurately inferring the genome-wide landscape of recombination rates in natural populations is a central aim in genomics, as patterns of linkage influence everything from genetic mapping to understanding evolutionary history. Here, we describe recombination landscape estimation using recurrent neural networks (ReLERN...

journal_title：Molecular biology and evolution

authors： Adrion JR,Galloway JG,Kern AD

更新日期：2020-06-01 00:00:00

abstract：:Dinoflagellates are algae of tremendous importance to ecosystems and to public health. The cell biology and genome organization of dinoflagellate species is highly unusual. For example, the plastid genomes of peridinin-containing dinoflagellates encode only a minimal number of genes arranged on small elements termed "...

journal_title：Molecular biology and evolution

authors： Dorrell RG,Klinger CM,Newby RJ,Butterfield ER,Richardson E,Dacks JB,Howe CJ,Nisbet ER,Bowler C

更新日期：2017-02-01 00:00:00

abstract：:Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to determine the dynamics of spontaneous mitochondrial mutations in small populations in the absence and presence of selection, we evolved mut...

journal_title：Molecular biology and evolution

authors： Konrad A,Thompson O,Waterston RH,Moerman DG,Keightley PD,Bergthorsson U,Katju V

更新日期：2017-06-01 00:00:00

abstract：:Most of the well-characterized mitochondrial genomes from diverse green algal lineages are circular mapping DNA molecules; however, Chlamydomonas reinhardtii has a linear 15.8 kb unit mitochondrial genome with 580 or 581 bp inverted repeat ends. In mitochondrial-enriched fractions prepared from Polytomella parva (=P. ...

journal_title：Molecular biology and evolution

authors： Fan J,Lee RW

更新日期：2002-07-01 00:00:00

abstract：:Previous studies on human mitochondrial genomes showed that the ratio of intra-specific diversities at nonsynonymous-to-synonymous positions was two to ten times higher than the ratio of interspecific divergences at these positions, suggesting an excess of slightly deleterious nonsynonymous polymorphisms. However, suc...

journal_title：Molecular biology and evolution

authors： Subramanian S

更新日期：2011-01-01 00:00:00

abstract：:The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient superficial cell layers and help to limit water loss to the envir...

journal_title：Molecular biology and evolution

authors： Strasser B,Mlitz V,Hermann M,Rice RH,Eigenheer RA,Alibardi L,Tschachler E,Eckhart L

更新日期：2014-12-01 00:00:00

abstract：:A central problem in evolutionary theory concerns the mechanisms by which adaptations requiring multiple mutations emerge in natural populations. We develop a series of expressions that clarify the scaling of the time to establishment of complex adaptations with population size, mutation rate, magnitude of the selecti...

journal_title：Molecular biology and evolution

authors： Lynch M,Abegg A

更新日期：2010-06-01 00:00:00

abstract：:The ancestral selection graph, conditioned on the allelic types in the sample, is used to obtain a limiting gene genealogical process under strong selection. In an equilibrium, two-allele system with strong selection, neutral gene genealogies are predicted for random samples and for samples containing at most one unfa...

journal_title：Molecular biology and evolution

authors： Wakeley J

更新日期：2008-12-01 00:00:00

abstract：:The noncoding-DNA content of organelle and nuclear genomes can vary immensely. Both adaptive and nonadaptive explanations for this variation have been proposed. This study addresses a nonadaptive explanation called the mutational-hazard hypothesis and applies it to the mitochondrial, plastid, and nuclear genomes of th...

journal_title：Molecular biology and evolution

authors： Smith DR,Lee RW

更新日期：2010-10-01 00:00:00

abstract：:Alu is a predominant short interspersed element (SINE) family in the human genome and consists of two monomer units connected by an A-rich linker. At present, dimeric Alu elements are active in humans, but Alu monomers are present as fossilized sequences. A comparative genome analysis of human and chimpanzee genomes r...

journal_title：Molecular biology and evolution

authors： Kojima KK

更新日期：2011-01-01 00:00:00

abstract：:4.5SH RNA is a 94-nt small RNA with unknown function. This RNA is known to be present in the mouse, rat, and hamster cells; however, it is not found in human, rabbit, and chicken. In the mouse genome, the 4.5SH RNA gene is a part of a long (4.2 kb) tandem repeat ( approximately 800 copies) unit. Here, we found that 4....

journal_title：Molecular biology and evolution

authors： Gogolevskaya IK,Koval AP,Kramerov DA

更新日期：2005-07-01 00:00:00

abstract：:Short interspersed repetitive elements (SINEs) have been shown to be excellent markers of molecular phylogeny, since the integration of a SINE at a particular position in a genome can be considered an unambiguous derived homologous character. In the present study, we isolated a new family of SINEs from cichlids in Lak...

journal_title：Molecular biology and evolution

authors： Takahashi K,Terai Y,Nishida M,Okada N

更新日期：1998-04-01 00:00:00

abstract：:Indirect tests have detected recombination in mitochondrial DNA (mtDNA) from many animal lineages, including mammals. However, it is possible that features of the molecular evolutionary process without recombination could be incorrectly inferred by indirect tests as being due to recombination. We have identified one s...

journal_title：Molecular biology and evolution

authors： Sun S,Evans BJ,Golding GB

更新日期：2011-09-01 00:00:00

abstract：:A large majority of bacterial genomes show strand asymmetry, such that G and T preferentially accumulate on the leading strand. The mechanisms are unknown, but cytosine deaminations are thought to play an important role. Here, we have examined DNA strand asymmetry in three strains of the aphid endosymbiont Buchnera ap...

journal_title：Molecular biology and evolution

authors： Klasson L,Andersson SG

更新日期：2006-05-01 00:00:00

abstract：:Modifications to transcriptional regulators play a major role in adaptation. Here, we compared the effects of multiple beneficial mutations within and between Escherichia coli rpoB, the gene encoding the RNA polymerase β subunit, and rho, which encodes a transcriptional terminator. These two genes have harbored adapti...

journal_title：Molecular biology and evolution

authors： González-González A,Hug SM,Rodríguez-Verdugo A,Patel JS,Gaut BS

更新日期：2017-11-01 00:00:00

abstract：:The adaptive significance of enzyme variation has been of central interest in population genetics. Yet, how natural selection operates on enzymes in the larger context of biochemical pathways has not been broadly explored. A basic expectation is that natural selection on metabolic phenotypes will target enzymes that c...

journal_title：Molecular biology and evolution

authors： Flowers JM,Sezgin E,Kumagai S,Duvernell DD,Matzkin LM,Schmidt PS,Eanes WF

更新日期：2007-06-01 00:00:00

abstract：:There is increasing evidence that X chromosomes have an unusual complement of genes, especially genes that have sex-specific expression. However, whereas in worm and fly the X chromosome has a dearth of male-specific genes, in mice genes that are uniquely expressed in spermatogonia are especially abundant on the X chr...

journal_title：Molecular biology and evolution

authors： Lercher MJ,Urrutia AO,Hurst LD

更新日期：2003-07-01 00:00:00

abstract：:Genome and transcript sequences are composed of long strings of nucleotide monomers (A, C, G, and T/U) that require different quantities of nitrogen atoms for biosynthesis. Here, it is shown that the strength of selection acting on transcript nitrogen content is influenced by the amount of nitrogen plants require to c...

journal_title：Molecular biology and evolution

authors： Kelly S

更新日期：2018-07-01 00:00:00