Abstract:
:The ancestral selection graph, conditioned on the allelic types in the sample, is used to obtain a limiting gene genealogical process under strong selection. In an equilibrium, two-allele system with strong selection, neutral gene genealogies are predicted for random samples and for samples containing at most one unfavorable allele. Samples containing more than one unfavorable allele have gene genealogies that differ greatly from neutral predictions. However, they are related to neutral gene genealogies via the well-known Ewens sampling formula. Simulations show rapid convergence to limiting analytical predictions as the strength of selection increases. These results extend the idea of a soft selective sweep to deleterious alleles and have implications for the interpretation of polymorphism among disease-causing alleles in humans.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Wakeley Jdoi
10.1093/molbev/msn209subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2615-26issue
12eissn
0737-4038issn
1537-1719pii
msn209journal_volume
25pub_type
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