Abstract:
:Endogenous retroviruses provide molecular fossils for studying the ancient evolutionary history of retroviruses. Here, we report our independent discovery and analysis of endogenous lentiviral insertions (Mustelidae endogenous lentivirus [MELV]) within the genomes of weasel family (Mustelidae). Genome-scale screening identified MELV elements in the domestic ferret (Mustela putorius furo) genome (MELVmpf). MELVmpf exhibits a typical lentiviral genomic organization. Phylogenetic analyses position MELVmpf basal to either primate lentiviruses or feline immunodeficiency virus. Moreover, we verified the presence of MELV insertions in the genomes of several species of the Lutrinae and Mustelinae subfamilies but not the Martinae subfamily, suggesting that the invasion of MELV into the Mustelidae genomes likely took place between 8.8 and 11.8 Ma. The discovery of MELV in weasel genomes extends the host range of lentiviruses to the Caniformia (order Carnivora) and provides important insights into the prehistoric diversity of lentiviruses.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Han GZ,Worobey Mdoi
10.1093/molbev/mss126subject
Has Abstractpub_date
2012-10-01 00:00:00pages
2905-8issue
10eissn
0737-4038issn
1537-1719pii
mss126journal_volume
29pub_type
杂志文章abstract::Protamines are small, highly basic DNA-binding proteins found in the sperm of animals. Interestingly, the proportion of arginine residues in one type of protamine, protamine P1, is about 50% in mammals. Upon closer examination, it was found that both the total number of amino acids and the positions of arginine residu...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a026307
更新日期:2000-02-01 00:00:00
abstract::Transcriptional control of gene expression is regulated by biochemical interactions between cis-regulatory DNA sequences and trans-acting factors that form complex regulatory networks. Genetic changes affecting both cis- and trans-acting sequences in these networks have been shown to alter patterns of gene expression ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msx068
更新日期:2017-06-01 00:00:00
abstract::Examination of the genomic sequence of the telomere region makes it possible to understand the evolution of the structure of chromosomal ends. We compared the genomic sequences of 14 chromosomal ends of rice, Oryza sativa, L., on the basis of the variation in TTTAGGG repeats. In the proximal telomere repeats, nucleoti...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm227
更新日期:2008-01-01 00:00:00
abstract::Morphological innovations like the acquisition of the neural crest as well as gene family expansions by genome duplication are considered as major leaps in the evolution of the vertebrate lineage. Using comparative genomic analyses, we have reconstructed the evolutionary history of the endothelin system, a signaling p...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msp015
更新日期:2009-04-01 00:00:00
abstract::The marine cyanobacterium Prochlorococcus MED4 has the smallest sequenced genome of any photosynthetic organism. Prochlorococcus MED4 shares many genomic characteristics with chloroplasts and bacterial endosymbionts, including a reduced coding capacity, missing DNA repair genes, a minimal transcriptional regulatory ne...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msn217
更新日期:2009-01-01 00:00:00
abstract::In order to investigate divergence of immune regulation among Drosophila species, we have engaged in a study of innate immune function in F1 hybrids of Drosophila melanogaster and D. simulans. If pathways have diverged between the species such that incompatibilities have arisen between interacting components of the im...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msq146
更新日期:2010-11-01 00:00:00
abstract::Understanding genome and chromosome evolution is important for understanding genetic inheritance and evolution. Universal events comprising DNA replication, transcription, repair, mobile genetic element transposition, chromosome rearrangements, mitosis, and meiosis underlie inheritance and variation of living organism...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msr011
更新日期:2011-06-01 00:00:00
abstract::The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes posttranslationally. The small translocase of the inner mitochondrial membranes (TIMs) are a group of approximately 10 kDa proteins that function as chaperones to ferry the imported protein...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm031
更新日期:2007-05-01 00:00:00
abstract::Identifying the genomic basis underlying local adaptation is paramount to evolutionary biology, and bears many applications in the fields of conservation biology, crop, and animal breeding, as well as personalized medicine. Although many approaches have been developed to detect signatures of positive selection within ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy053
更新日期:2018-06-01 00:00:00
abstract::The rate of recombination impacts on rates of protein evolution for at least two reasons: it affects the efficacy of selection due to linkage and influences sequence evolution through the process of GC-biased gene conversion (gBGC). We studied how recombination, via gBGC, affects inferences of selection in gene sequen...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msy149
更新日期:2018-10-01 00:00:00
abstract::Sherpa population is an ethnic group living in south mountainside of Himalayas for hundreds of years. They are famous as extraordinary mountaineers and guides, considered as a good example for successful adaptation to low oxygen environment in Tibetan highlands. Mitochondrial DNA (mtDNA) variations might be important ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mst147
更新日期:2013-12-01 00:00:00
abstract::Some genes have repeatedly been found to control diverse adaptations in a wide variety of organisms. Such gene reuse reveals not only the diversity of phenotypes these unique genes control but also the composition of developmental gene networks and the genetic routes available to and taken by organisms during adaptati...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msz194
更新日期:2019-12-01 00:00:00
abstract::Current sequencing methods produce large amounts of data, but genome assemblies constructed from these data are often fragmented and incomplete. Incomplete and error-filled assemblies result in many annotation errors, especially in the number of genes present in a genome. This means that methods attempting to estimate...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mst100
更新日期:2013-08-01 00:00:00
abstract::Colias eurytheme butterflies display extensive allozyme polymorphism in the enzyme phosphoglucose isomerase (PGI). Earlier studies on biochemical and fitness effects of these genotypes found evidence of strong natural selection maintaining this polymorphism in the wild. Here we analyze the molecular features of this p...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msj062
更新日期:2006-03-01 00:00:00
abstract::The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced relatively low rates of gene gain and loss in multigene families. To investigate this possibility and to explore the phenotypic consequences of variation in gene copy number, we examined evolutionary changes in the famil...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msu341
更新日期:2015-04-01 00:00:00
abstract::Over time, natural selection molds every gene into a unique mosaic of sites evolving rapidly or resisting change-an "evolutionary fingerprint" of the gene. Aspects of this evolutionary fingerprint, such as the site-specific ratio of nonsynonymous to synonymous substitution rates (dN/dS), are commonly used to identify ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msp260
更新日期:2010-03-01 00:00:00
abstract::We measured nucleotide variability within and between the three semispecies of the Drosophila athabasca complex, at the period (per) gene by using a polymerase chain reaction-based four-cutter restriction-enzyme analysis. The levels of polymorphism varied considerably between the three semispecies. Our results for per...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040101
更新日期:1994-03-01 00:00:00
abstract::Although many phylogenetic studies have focused on developing hypotheses about relationships, advances in data collection and computation have increased the feasibility of collecting large independent data sets to rigorously test controversial hypotheses or carefully assess artifacts that may be misleading. One such r...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msr230
更新日期:2012-02-01 00:00:00
abstract::A more than 10-fold difference in the specificity and catalytic efficiency for 1-naphthyl esters was measured between two allozymes of esterase-4 from Drosophila mojavensis. This difference is mainly caused by a difference in the affinity for the 1-naphthyl esters. The amino acid compositions of the allozymes are not ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040403
更新日期:1986-07-01 00:00:00
abstract::Model-based analyses of natural selection often categorize sites into a relatively small number of site classes. Forcing each site to belong to one of these classes places unrealistic constraints on the distribution of selection parameters, which can result in misleading inference due to model misspecification. We pre...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mst030
更新日期:2013-05-01 00:00:00
abstract::Traditionally, living cetaceans (order Cetacea) are classified into two highly distinct suborders: the echolocating toothed whales, Odontoceti, and the filter-feeding baleen whales, Mysticeti. A molecular phylogeny based on 1,352 base pairs of two mitochondrial ribosomal gene segments and the mitochondrial cytochrome ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040164
更新日期:1994-11-01 00:00:00
abstract::The fossil record has long supported the view that most animal phyla originated during a brief period approximately 520 MYA known as the Cambrian explosion. However, molecular data analyses over the past 3 decades have found deeper divergences among animals (approximately 800 to 1,200 MYA), with and without the assump...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msi039
更新日期:2005-03-01 00:00:00
abstract::The adaptive significance of enzyme variation has been of central interest in population genetics. Yet, how natural selection operates on enzymes in the larger context of biochemical pathways has not been broadly explored. A basic expectation is that natural selection on metabolic phenotypes will target enzymes that c...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msm057
更新日期:2007-06-01 00:00:00
abstract::We implement an isolation with migration model for three species, with migration occurring between two closely related species while an out-group species is used to provide further information concerning gene trees and model parameters. The model is implemented in the likelihood framework for analyzing multilocus geno...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mss118
更新日期:2012-10-01 00:00:00
abstract::Phenotypes and behaviors respond to resource constraints via adaptation, but the influence of ecological limitations on the composition of eukaryotic genomes is still unclear. We trace connections between plant ecology and genomes through their elemental composition. Inorganic sources of nitrogen (N) are severely limi...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msp038
更新日期:2009-05-01 00:00:00
abstract::Polygalacturonase inhibitor proteins (PGIPs) protect plants against invasion by diverse microbial and invertebrate enemies that use polygalacturonase (PG) to breach the plant cell wall. Directed mutagenesis has identified specific natural mutations conferring novel defensive capability in green bean PGIP against a spe...
journal_title:Molecular biology and evolution
pub_type: 信件
doi:10.1093/molbev/msi146
更新日期:2005-07-01 00:00:00
abstract::The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to lower barometric pressures and hence atmospheric partial pressures of oxygen. Such "hypobaric hypoxia" may limit physical functional capacity, reproductive health, ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mst089
更新日期:2013-08-01 00:00:00
abstract::Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are ubiquitous human pathogens. Both viruses evolved from simplex viruses infecting African primates and they are thus thought to have left Africa during early human migrations. We analyzed the population structure of HSV-1 and HSV-2 circulating strains. Results ind...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msaa001
更新日期:2020-05-01 00:00:00
abstract::The MIKC MADS-box gene family has been shaped by extensive gene duplications giving rise to subfamilies of genes with distinct functions and expression patterns. However, within these subfamilies the functional assignment is not that clear-cut, and considerable functional redundancy exists. One way to investigate the ...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msk016
更新日期:2006-06-01 00:00:00
abstract::Although endogenous retroviruses are common across vertebrate genomes, the koala retrovirus (KoRV) is the only retrovirus known to be currently invading the germ line of its host. KoRV is believed to have first infected koalas in northern Australia less than two centuries ago. We examined KoRV in 28 koala museum skins...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mss223
更新日期:2013-02-01 00:00:00