Abstract:
:The MIKC MADS-box gene family has been shaped by extensive gene duplications giving rise to subfamilies of genes with distinct functions and expression patterns. However, within these subfamilies the functional assignment is not that clear-cut, and considerable functional redundancy exists. One way to investigate the diversity in regulation present in these subfamilies is promoter sequence analysis. With the advent of genome sequencing projects, we are now able to exert a comparative analysis of Arabidopsis and poplar promoters of MADS-box genes belonging to the same subfamily. Based on the principle of phylogenetic footprinting, sequences conserved between the promoters of homologous genes are thought to be functional. Here, we have investigated the evolution of MADS-box genes at the promoter level and show that many genes have diverged in their regulatory sequences after duplication and/or speciation. Furthermore, using phylogenetic footprinting, a distinction can be made between redundancy, neo/nonfunctionalization, and subfunctionalization.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
De Bodt S,Theissen G,Van de Peer Ydoi
10.1093/molbev/msk016subject
Has Abstractpub_date
2006-06-01 00:00:00pages
1293-303issue
6eissn
0737-4038issn
1537-1719pii
msk016journal_volume
23pub_type
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