Protein expansion is primarily due to indels in intrinsically disordered regions.

abstract：:Short interspersed repetitive elements (SINEs) have been shown to be excellent markers of molecular phylogeny, since the integration of a SINE at a particular position in a genome can be considered an unambiguous derived homologous character. In the present study, we isolated a new family of SINEs from cichlids in Lak...

journal_title：Molecular biology and evolution

authors： Takahashi K,Terai Y,Nishida M,Okada N

更新日期：1998-04-01 00:00:00

abstract：:Copy number variants (CNVs) within humans can have both adaptive and deleterious effects. Because of their phenotypic significance, researchers have attempted to find single nucleotide polymorphisms (SNPs) in high linkage disequilibrium (LD) with CNVs to use in genomewide association studies. However, studies have fou...

journal_title：Molecular biology and evolution

authors： Schrider DR,Hahn MW

更新日期：2010-01-01 00:00:00

abstract：:We propose an improved version of the neighbor-joining (NJ) algorithm of Saitou and Nei. This new algorithm, BIONJ, follows the same agglomerative scheme as NJ, which consists of iteratively picking a pair of taxa, creating a new mode which represents the cluster of these taxa, and reducing the distance matrix by repl...

journal_title：Molecular biology and evolution

authors： Gascuel O

更新日期：1997-07-01 00:00:00

abstract：:The emergence of islands has been linked to spectacular radiations of diverse organisms. Although penguins spend much of their lives at sea, they rely on land for nesting, and a high proportion of extant species are endemic to geologically young islands. Islands may thus have been crucial to the evolutionary diversifi...

journal_title：Molecular biology and evolution

authors： Cole TL,Ksepka DT,Mitchell KJ,Tennyson AJD,Thomas DB,Pan H,Zhang G,Rawlence NJ,Wood JR,Bover P,Bouzat JL,Cooper A,Fiddaman SR,Hart T,Miller G,Ryan PG,Shepherd LD,Wilmshurst JM,Waters JM

更新日期：2019-04-01 00:00:00

abstract：:Much of evolutionary change is mediated at the level of gene expression, yet our understanding of regulatory evolution remains unsatisfying. In light of recent data indicating that transcription factor binding sites undergo substantial turnover between species, we attempt to quantify the process of binding site turnov...

journal_title：Molecular biology and evolution

authors： Dermitzakis ET,Bergman CM,Clark AG

更新日期：2003-05-01 00:00:00

abstract：:In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental g...

journal_title：Molecular biology and evolution

authors： Perry GH,Verrelli BC,Stone AC

更新日期：2006-03-01 00:00:00

abstract：:Comparisons between human and rodent DNA sequences are widely used for the identification of regulatory regions (phylogenetic footprinting), and the importance of such intergenomic comparisons for promoter annotation is expanding. The efficacy of such comparisons for the identification of functional regulatory element...

journal_title：Molecular biology and evolution

authors： Dermitzakis ET,Clark AG

更新日期：2002-07-01 00:00:00

abstract：:Flowering time is one of the key determinants of crop adaptation to local environments during domestication. However, the genetic basis underlying flowering time is yet to be elucidated in most cereals. Although staple cereals, such as rice, maize, wheat, barley, and sorghum, have spread and adapted to a wide range of...

journal_title：Molecular biology and evolution

authors： Liu H,Liu H,Zhou L,Zhang Z,Zhang X,Wang M,Li H,Lin Z

更新日期：2015-10-01 00:00:00

abstract：:We performed a genealogical analysis of the ionotropic glutamate receptor (iGluR) gene family, which includes the animal iGluRs and the newly isolated glutamate receptor-like genes (GLR) of plants discovered in Arabidopsis. Distance measures firmly placed the plant GLR genes within the iGluR clade as opposed to other ...

journal_title：Molecular biology and evolution

authors： Chiu J,DeSalle R,Lam HM,Meisel L,Coruzzi G

更新日期：1999-06-01 00:00:00

abstract：:Previous studies have shown that genes that are expressed predominantly or exclusively in males tend to evolve rapidly in comparison to other genes. In most cases, however, it is unknown whether this rapid evolution is the result of increased positive (or sexual) selection on male-expressed traits or if it is due to a...

journal_title：Molecular biology and evolution

authors： Zhang Z,Parsch J

更新日期：2005-10-01 00:00:00

abstract：:We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In addition to well-known g...

journal_title：Molecular biology and evolution

authors： Xu L,Bickhart DM,Cole JB,Schroeder SG,Song J,Tassell CP,Sonstegard TS,Liu GE

更新日期：2015-03-01 00:00:00

abstract：:This study aims to unravel the biogeography of a model symbiont/host system by exploiting the prediction that a symbiont will leave a signature of infection on the host. Specifically, a global sample of 1,442 Drosophila simulans from 33 countries and 64 sampling localities was employed to infer the phylogeography of t...

journal_title：Molecular biology and evolution

authors： Ballard JW

更新日期：2004-03-01 00:00:00

abstract：:Various hypotheses for the peopling of the Japanese archipelago have been proposed, which can be classified into three models: transformation, replacement, and hybridization. In recent years, one of the hybridization models ("dual-structure model") has been widely accepted. According to this model, Neolithic hunter-ga...

journal_title：Molecular biology and evolution

authors： Nakagome S,Sato T,Ishida H,Hanihara T,Yamaguchi T,Kimura R,Mano S,Oota H,Asian DNA Repository Consortium.

更新日期：2015-06-01 00:00:00

abstract：:Recently, Lee et al. (Lee JH, Silhavy JL, Lee JE, et al. (30 co-authors). 2012. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Science (335:966-969.) demonstrated that mutation in either of the transmembrane protein encoding genes, TMEM138 or TMEM216, causes phenotypically indistinguishabl...

journal_title：Molecular biology and evolution

authors： Venkatesh B,Ravi V,Lee AP,Warren WC,Brenner S

更新日期：2013-01-01 00:00:00

abstract：:The human scavenger receptor class B type I (SR-BI and splice variant SR-BII) plays a central role in HDL cholesterol metabolism and represents a candidate gene for a number of related diseases. We examined the genetic diversity of its coding and flanking regions in a sample of 178 chromosomes from individuals of Euro...

journal_title：Molecular biology and evolution

authors： Le Jossec M,Wambach T,Labuda D,Sinnett D,Levy E

更新日期：2004-04-01 00:00:00

abstract：:Statistical analyses of DNA sequences of the preproglucagon genes from bovine, human, hamster, and anglerfish suggest that a gene duplication creating two anglerfish genes (AF I and II) occurred about 160 Myr ago, long after the separation of fish and mammals. The analyses further suggest that the internal duplication...

journal_title：Molecular biology and evolution

authors： Lopez LC,Li WH,Frazier ML,Luo CC,Saunders GF

更新日期：1984-07-01 00:00:00

abstract：:Horizontal gene transfer threatens the therapeutic success of antibiotics by facilitating the rapid dissemination of resistance alleles among bacterial species. The conjugative mobile element Tn916 provides an excellent context for examining the role of adaptive parasexuality as it carries the tetracycline-resistance ...

journal_title：Molecular biology and evolution

authors： Beabout K,Hammerstrom TG,Wang TT,Bhatty M,Christie PJ,Saxer G,Shamoo Y

更新日期：2015-10-01 00:00:00

abstract：:Transposable elements (TEs) make up around 10%-15% of the Drosophila melanogaster genome, but its sibling species Drosophila simulans carries only one third as many such repeat sequences. We do not, however, have an overall view of copy numbers of the various classes of TEs (long terminal repeat [LTR] retrotransposons...

journal_title：Molecular biology and evolution

authors： Vieira C,Lepetit D,Dumont S,Biémont C

更新日期：1999-09-01 00:00:00

abstract：:How is adaptability generated in a system composed of interacting cellular machineries, each with a separate and functionally critical job to perform? The machinery for organelle inheritance is precisely one such system, requiring coordination between robust and ancient cellular modules, including the cell cycle, cyto...

journal_title：Molecular biology and evolution

authors： Mast FD,Rachubinski RA,Dacks JB

更新日期：2012-03-01 00:00:00

abstract：:Cytochrome c oxidase (COX) consists of 13 subunits, 3 encoded in the mitochondrial genome and 10 in the nucleus. Little is known of the role of the nuclear-encoded subunits, some of which exhibit tissue-specific isoforms. Subunit VIa is unique in having tissue-specific isoforms in all mammalian species examined. We ex...

journal_title：Molecular biology and evolution

authors： Schmidt TR,Jaradat SA,Goodman M,Lomax MI,Grossman LI

更新日期：1997-06-01 00:00:00

abstract：:Gene expression changes contribute to complex trait variations in both individuals and populations. However, the evolution of gene expression underlying complex traits over macroevolutionary timescales remains poorly understood. Snake venoms are proteinaceous cocktails where the expression of each toxin can be quantif...

journal_title：Molecular biology and evolution

authors： Barua A,Mikheyev AS

更新日期：2019-09-01 00:00:00

abstract：:Signaling peptides enable communication between cells, both within and between individuals, and are therefore key to the control of complex physiological and behavioral responses. Since their small sizes prevent direct transmission to secretory pathways, these peptides are often produced as part of a larger polyprotei...

journal_title：Molecular biology and evolution

authors： Rogers DW,McConnell E,Miller EL,Greig D

更新日期：2017-12-01 00:00:00

abstract：:Plant phenotypic plasticity describes altered phenotypic performance of an individual when grown in different environments. Exploring genetic architecture underlying plant plasticity variation may help mitigate the detrimental effects of a rapidly changing climate on agriculture, but little research has been done in t...

journal_title：Molecular biology and evolution

authors： Liu N,Du Y,Warburton ML,Xiao Y,Yan J

更新日期：2020-11-03 00:00:00

abstract：:Hitchhiking effects of advantageous mutations have been invoked to explain reduced polymorphism in regions of low crossing-over in Drosophila. Besides reducing DNA heterozygosity, hitchhiking effects should produce strong linkage disequilibrium and a frequency spectrum skewed toward an excess of rare polymorphisms (co...

journal_title：Molecular biology and evolution

authors： Begun DJ,Aquadro CF

更新日期：1995-05-01 00:00:00

abstract：:We determine the phylogenetic backbone of the East Asian mtDNA tree by using published complete mtDNA sequences and assessing both coding and control region variation in 69 Han individuals from southern China. This approach assists in the interpretation of published mtDNA data on East Asians based on either control re...

journal_title：Molecular biology and evolution

authors： Kivisild T,Tolk HV,Parik J,Wang Y,Papiha SS,Bandelt HJ,Villems R

更新日期：2002-10-01 00:00:00

abstract：:Many intron positions are conserved in varying subsets of eukaryotic genomes and, consequently, comprise a potentially informative class of phylogenetic characters. Roy and Gilbert developed a method of phylogenetic reconstruction using the patterns of intron presence-absence in eukaryotic genes and, applying this met...

journal_title：Molecular biology and evolution

authors： Zheng J,Rogozin IB,Koonin EV,Przytycka TM

更新日期：2007-11-01 00:00:00

abstract：:Here, we sequenced the 5,419,609 bp circular genome of an Enterobacter aerogenes clinical isolate that killed a patient and was resistant to almost all current antibiotics (except gentamicin) commonly used to treat Enterobacterial infections, including colistin. Genomic and phylogenetic analyses explain the discrepanc...

journal_title：Molecular biology and evolution

authors： Diene SM,Merhej V,Henry M,El Filali A,Roux V,Robert C,Azza S,Gavory F,Barbe V,La Scola B,Raoult D,Rolain JM

更新日期：2013-02-01 00:00:00

abstract：:Rubisco, the primary photosynthetic carboxylase, evolved 3-4 billion years ago in an anaerobic, high CO(2) atmosphere. The combined effect of low CO(2) and high O(2) levels in the modern atmosphere, and the inability of Rubisco to distinguish completely between CO(2) and O(2), leads to the occurrence of an oxygenation...

journal_title：Molecular biology and evolution

authors： Kapralov MV,Kubien DS,Andersson I,Filatov DA

更新日期：2011-04-01 00:00:00

abstract：:Animal microRNAs (miRNAs) are short RNAs that function as posttranscriptional regulators of gene expression by binding to the target mRNAs. Noting that some miRNAs are highly conserved in evolution, we explored the possibility of evolutionary conservation of their targets. We identified human orthologues of experiment...

journal_title：Molecular biology and evolution

authors： Lin YC,Hsieh LC,Kuo MW,Yu J,Kuo HH,Lo WL,Lin RJ,Yu AL,Li WH

更新日期：2007-11-01 00:00:00

abstract：:The adaptive radiation of cichlid fishes in East African Lake Malawi encompasses over 500 species that are believed to have evolved within the last 800,000 years from a common founder population. It has been proposed that hybridization between ancestral lineages can provide the genetic raw material to fuel such except...

journal_title：Molecular biology and evolution

authors： Svardal H,Quah FX,Malinsky M,Ngatunga BP,Miska EA,Salzburger W,Genner MJ,Turner GF,Durbin R

更新日期：2020-04-01 00:00:00