Genetic diversity patterns in the SR-BI/II locus can be explained by a recent selective sweep.

Abstract:

:The human scavenger receptor class B type I (SR-BI and splice variant SR-BII) plays a central role in HDL cholesterol metabolism and represents a candidate gene for a number of related diseases. We examined the genetic diversity of its coding and flanking regions in a sample of 178 chromosomes from individuals of European, African, East Asian (including Southeast Asian), Middle-Eastern as well as Amerindian descent. Nine of the 14 polymorphisms observed are new. Four of the five variants causing amino acid replacements, G2S, S229G, R484W, and G499R, are likely to affect protein structure and function. SR-BI/BII diversity is partitioned among 19 haplotypes; all but one interconnected by single mutation or a recombination event. Such tight haplotype network and the unusual geographic partitioning of this diversity, high not only in Africa but in East Asia as well, suggests its recent origin and possible effect of selection. Coalescent analysis infers a relatively short time to the most recent common ancestor and points to population expansion in Africa and East Asia. These two continents differ significantly in pairwise F(ST) values, differing as well from a single cluster formed by Europe, Middle East and America. In the context of findings for similarly analyzed other loci, we propose that a selective sweep at the origin of modern human populations could explain the low level of ancestral SR-BI/II diversity. The unusually deep split between Africa and Asia, well beyond the Upper Paleolithic when inferred under neutrality, is consistent with subsequent geographical and demographic expansion favoring the accumulation of new variants, especially in groups characterized by large effective population sizes, such as Asians and Africans. The relevance of such partitioning of SR-BI/II diversity remains to be investigated in genetic epidemiological studies which can be guided by the present findings.

journal_name

Mol Biol Evol

authors

Le Jossec M,Wambach T,Labuda D,Sinnett D,Levy E

doi

10.1093/molbev/msh074

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

760-9

issue

4

eissn

0737-4038

issn

1537-1719

pii

msh074

journal_volume

21

pub_type

杂志文章
  • Evolution of clonality and polyploidy in a weevil system.

    abstract::The increased interest in asexual organisms calls for in-depth studies of asexual complexes that actively give rise to new clones. We present an extensive molecular study of the Otiorhynchus scaber (Coleoptera, Curculionidae) weevil system. Three forms have traditionally been recognized: diploid sexuals, triploid, and...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msg180

    authors: Stenberg P,Lundmark M,Knutelski S,Saura A

    更新日期:2003-10-01 00:00:00

  • A Robust ANOVA Approach to Estimating a Phylogeny from Multiple Genes.

    abstract::In this article, we address the issue of estimating the phylogenetic tree based on sequence data across a set of genes. Recognizing that the individual gene trees may not all share the same evolutionary history due to lateral gene transfer or differences in rates of evolution for instance, we develop a robust algorith...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msv084

    authors: Xu X,Dunn KA,Field C

    更新日期:2015-08-01 00:00:00

  • Chromosome-specific distribution of nucleotide substitutions in telomeric repeats of rice (Oryza sativa L.).

    abstract::Examination of the genomic sequence of the telomere region makes it possible to understand the evolution of the structure of chromosomal ends. We compared the genomic sequences of 14 chromosomal ends of rice, Oryza sativa, L., on the basis of the variation in TTTAGGG repeats. In the proximal telomere repeats, nucleoti...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msm227

    authors: Mizuno H,Wu J,Katayose Y,Kanamori H,Sasaki T,Matsumoto T

    更新日期:2008-01-01 00:00:00

  • Gene regulatory divergence among species estimated by altered developmental patterns in interspecific hybrids.

    abstract::Disturbances in the schedules of gene expression in developing interspecific fish hybrids have been used to draw inferences about the extent of gene regulatory divergence between species and about the degree to which this gene regulatory divergence is correlated with structural gene divergence, as estimated by genetic...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.molbev.a040349

    authors: Parker HR,Philipp DP,Whitt GS

    更新日期:1985-05-01 00:00:00

  • Nineteenth century seeds reveal the population genetics of landrace barley (Hordeum vulgare).

    abstract::Barley (Hordeum vulgare) is a major crop, grown worldwide and in a wide range of climatic conditions. Despite its importance as a crop species, little is known about the population genetics of barley and the effects of bottlenecks, adaptation, and gene flow on genetic diversity within and between landrace populations....

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msp308

    authors: Leino MW,Hagenblad J

    更新日期:2010-04-01 00:00:00

  • Quantitative Mass Spectrometry Reveals Partial Translational Regulation for Dosage Compensation in Chicken.

    abstract::There is increasing evidence that dosage compensation is not a ubiquitous feature following sex chromosome evolution, especially not in organisms where females are the heterogametic sex, like in birds. Even when it occurs, compensation can be incomplete and limited to dosage-sensitive genes. However, previous work has...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msv147

    authors: Uebbing S,Konzer A,Xu L,Backström N,Brunström B,Bergquist J,Ellegren H

    更新日期:2015-10-01 00:00:00

  • Molecular evolution of the 5'-flanking regions of the duplicated Amy genes in Drosophila melanogaster species subgroup.

    abstract::The nucleotide sequences of the 5'-flanking regions of the duplicated Amy genes in eight sibling species belonging to the melanogaster species subgroup are analyzed. In Drosophila melanogaster, a region of about 450 bp immediately upstream of the translation initiation site of the two paralogous genes (the proximal an...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a025617

    authors: Okuyama E,Shibata H,Tachida H,Yamazaki T

    更新日期:1996-04-01 00:00:00

  • How Long Does Wolbachia Remain on Board?

    abstract::Wolbachia bacteria infect about half of all arthropods, with diverse and extreme consequences ranging from sex-ratio distortion and mating incompatibilities to protection against viruses. These phenotypic effects, combined with efficient vertical transmission from mothers to offspring, satisfactorily explain the invas...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msx073

    authors: Bailly-Bechet M,Martins-Simões P,Szöllosi GJ,Mialdea G,Sagot MF,Charlat S

    更新日期:2017-05-01 00:00:00

  • Emergent complexity in Myosin V-based organelle inheritance.

    abstract::How is adaptability generated in a system composed of interacting cellular machineries, each with a separate and functionally critical job to perform? The machinery for organelle inheritance is precisely one such system, requiring coordination between robust and ancient cellular modules, including the cell cycle, cyto...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msr264

    authors: Mast FD,Rachubinski RA,Dacks JB

    更新日期:2012-03-01 00:00:00

  • Molecular evolution and phylogenetic utility of Wolbachia ftsZ and wsp gene sequences with special reference to the origin of male-killing.

    abstract::A detailed assessment of the evolution and phylogenetic utility of two genes, ftsZ and wsp, was used to investigate the origin of male-killing Wolbachia, previously isolated from the ladybird Adalia bipunctata and the butterfly Acraea encedon. The analysis included almost all available sequences of B-group Wolbachia a...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a026338

    authors: Schulenburg JH,Hurst GD,Huigens TM,van Meer MM,Jiggins FM,Majerus ME

    更新日期:2000-04-01 00:00:00

  • A highly conserved nuclear gene for low-level phylogenetics: elongation factor-1 alpha recovers morphology-based tree for heliothine moths.

    abstract::Molecular systematists need increased access to nuclear genes. Highly conserved, low copy number protein-encoding nuclear genes have attractive features for phylogenetic inference but have heretofore been applied mostly to very ancient divergences. By virtue of their synonymous substitutions, such genes should contain...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a040244

    authors: Cho S,Mitchell A,Regier JC,Mitter C,Poole RW,Friedlander TP,Zhao S

    更新日期:1995-07-01 00:00:00

  • Layers of evolvability in a bacteriophage life history trait.

    abstract::Functional redundancy in genomes arises from genes with overlapping functions, allowing phenotypes to persist after gene knockouts. Evolutionary redundancy or evolvability of a genome is one step removed, in that functional redundancy is absent but the genome has the potential to evolve to restore a lost phenotype. Ex...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msp037

    authors: Heineman RH,Bull JJ,Molineux IJ

    更新日期:2009-06-01 00:00:00

  • Colocality to Cofunctionality: Eukaryotic Gene Neighborhoods as a Resource for Function Discovery.

    abstract::Diverging from the classic paradigm of random gene order in eukaryotes, gene proximity can be leveraged to systematically identify functionally related gene neighborhoods in eukaryotes, utilizing techniques pioneered in bacteria. Current methods of identifying gene neighborhoods typically rely on sequence similarity t...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msaa221

    authors: Foflonker F,Blaby-Haas CE

    更新日期:2021-01-23 00:00:00

  • Microsatellites as targets of natural selection.

    abstract::The ability to survey polymorphism on a genomic scale has enabled genome-wide scans for the targets of natural selection. Theory that connects patterns of genetic variation to evidence of natural selection most often assumes a diallelic locus and no recurrent mutation. Although these assumptions are suitable to select...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/mss247

    authors: Haasl RJ,Payseur BA

    更新日期:2013-02-01 00:00:00

  • Position of the final intron in full-length transcripts: determined by NMD?

    abstract::Nonsense-mediated decay (NMD) pathways for detection and degradation of transcripts containing premature termination (stop) codons (PTCs) are ubiquitous among the eukaryotes. NMD uses the presence of a second signal downstream of a termination codon to distinguish a PTC from a true stop codon. In mammals and perhaps o...

    journal_title:Molecular biology and evolution

    pub_type: 信件

    doi:10.1093/molbev/msm010

    authors: Scofield DG,Hong X,Lynch M

    更新日期:2007-04-01 00:00:00

  • Molecular phylogeny of the springhare, Pedetes capensis, based on mitochondrial DNA sequences.

    abstract::The phylogenetic position of the Pedetidae, represented by a single species Pedetes capensis, is controversial, reflecting in part the retention of both Hystricomorphous and Sciurognathous characteristics in this rodent. In an attempt to clarify the species evolutionary relationships, mtDNA gene sequences from 10 rode...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a025698

    authors: Matthee CA,Robinson TJ

    更新日期:1997-01-01 00:00:00

  • Mitochondrial DNA in the sea urchin Arbacia lixula: evolutionary inferences from nucleotide sequence analysis.

    abstract::From the stirodont Arbacia lixula we determined the sequence of 5,127 nucleotides of mitochondrial DNA (mtDNA) encompassing 18 tRNAs, two complete coding genes, parts of three other coding genes, and part of the 12S ribosomal RNA (rRNA). The sequence confirms that the organization of mtDNA is conserved within echinoid...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a040661

    authors: De Giorgi C,Lanave C,Musci MD,Saccone C

    更新日期:1991-07-01 00:00:00

  • Many Options, Few Solutions: Over 60 My Snakes Converged on a Few Optimal Venom Formulations.

    abstract::Gene expression changes contribute to complex trait variations in both individuals and populations. However, the evolution of gene expression underlying complex traits over macroevolutionary timescales remains poorly understood. Snake venoms are proteinaceous cocktails where the expression of each toxin can be quantif...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msz125

    authors: Barua A,Mikheyev AS

    更新日期:2019-09-01 00:00:00

  • Adjusting for selection on synonymous sites in estimates of evolutionary distance.

    abstract::Evolution at silent sites is often used to estimate the pace of selectively neutral processes or to infer differences in divergence times of genes. However, silent sites are subject to selection in favor of preferred codons, and the strength of such selection varies dramatically across genes. Here, we use the relation...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msh265

    authors: Hirsh AE,Fraser HB,Wall DP

    更新日期:2005-01-01 00:00:00

  • Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.

    abstract::The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to lower barometric pressures and hence atmospheric partial pressures of oxygen. Such "hypobaric hypoxia" may limit physical functional capacity, reproductive health, ...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/mst089

    authors: Huerta-Sánchez E,Degiorgio M,Pagani L,Tarekegn A,Ekong R,Antao T,Cardona A,Montgomery HE,Cavalleri GL,Robbins PA,Weale ME,Bradman N,Bekele E,Kivisild T,Tyler-Smith C,Nielsen R

    更新日期:2013-08-01 00:00:00

  • A phylogenetic mixture model for the evolution of gene expression.

    abstract::Microarray platforms are used increasingly to make comparative inferences through genome-wide surveys of gene expression. Although recent studies focus on describing the evidence for natural selection using estimates of the within- and between-taxa mutational variances, these methods do not explicitly or flexibly acco...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msp149

    authors: Eng KH,Bravo HC,Keleş S

    更新日期:2009-10-01 00:00:00

  • Patterns of mutation and selection at synonymous sites in Drosophila.

    abstract::That natural selection affects molecular evolution at synonymous sites in protein-coding sequences is well established and is thought to predominantly reflect selection for translational efficiency/accuracy mediated through codon bias. However, a recently developed maximum likelihood framework, when applied to 18 codi...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msm196

    authors: Singh ND,Bauer DuMont VL,Hubisz MJ,Nielsen R,Aquadro CF

    更新日期:2007-12-01 00:00:00

  • Can deleterious mutations explain the time dependency of molecular rate estimates?

    abstract::It has recently been observed by Ho et al. (Ho SYW, Phillips MJ, Cooper A, Drummond AJ. 2005. Time dependency of molecular rate estimates and systematic overestimation of recent divergence times. Mol Biol Evol. 22(7):1561-1568) that apparent rates of molecular evolution increase when measured over short timespans. I i...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msl107

    authors: Woodhams M

    更新日期:2006-12-01 00:00:00

  • Influence of mutational and sampling factors on the estimation of demographic parameters in a "continuous" population under isolation by distance.

    abstract::In numerous species, individual dispersal is restricted in space so that "continuous" populations evolve under isolation by distance. A method based on individual genotypes assuming a lattice population model was recently developed to estimate the product Dsigma2, where D is the population density and sigma2 is the av...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msg034

    authors: Leblois R,Estoup A,Rousset F

    更新日期:2003-04-01 00:00:00

  • Analyzing the evolution of RNA secondary structures in vertebrate introns using Kimura's model of compensatory fitness interactions.

    abstract::Previous studies have shown that splicing efficiency, and thus maturation of pre-mRNA, depends on the correct folding of the RNA molecule into a secondary or higher order structure. When disrupted by a mutation, aberrant folding may result in a lower splicing efficiency. However, the structure can be restored by a sec...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msn195

    authors: Piskol R,Stephan W

    更新日期:2008-11-01 00:00:00

  • Elongation factor-1 alpha occurs as two copies in bees: implications for phylogenetic analysis of EF-1 alpha sequences in insects.

    abstract::We report the complete sequence of a paralogous copy of elongation factor-1 alpha (EF-1 alpha) in the honeybee, Apis mellifera (Hymenoptera: Apidae). This copy differs from a previously described copy in the positions of five introns and in 25% of the nucleotide sites in the coding regions. The existence of two paralo...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a025920

    authors: Danforth BN,Ji S

    更新日期:1998-03-01 00:00:00

  • Evolutionary origins of human herpes simplex viruses 1 and 2.

    abstract::Herpesviruses have been infecting and codiverging with their vertebrate hosts for hundreds of millions of years. The primate simplex viruses exemplify this pattern of virus-host codivergence, at a minimum, as far back as the most recent common ancestor of New World monkeys, Old World monkeys, and apes. Humans are the ...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msu185

    authors: Wertheim JO,Smith MD,Smith DM,Scheffler K,Kosakovsky Pond SL

    更新日期:2014-09-01 00:00:00

  • The chloroplast genomes of the green algae Pyramimonas, Monomastix, and Pycnococcus shed new light on the evolutionary history of prasinophytes and the origin of the secondary chloroplasts of euglenids.

    abstract::Because they represent the earliest divergences of the Chlorophyta and include the smallest known eukaryotes (e.g., the coccoid Ostreococcus), the morphologically diverse unicellular green algae making up the Prasinophyceae are central to our understanding of the evolutionary patterns that accompanied the radiation of...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msn285

    authors: Turmel M,Gagnon MC,O'Kelly CJ,Otis C,Lemieux C

    更新日期:2009-03-01 00:00:00

  • How meaningful are Bayesian support values?

    abstract::In this study, we used an empirical example based on 100 mitochondrial genomes from higher teleost fishes to compare the accuracy of parsimony-based jackknife values with Bayesian support values. Phylogenetic analyses of 366 partitions, using differential taxon and character sampling from the entire data matrix of 100...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/molbev/msh014

    authors: Simmons MP,Pickett KM,Miya M

    更新日期:2004-01-01 00:00:00

  • The relative contributions of recombination and mutation to the divergence of clones of Neisseria meningitidis.

    abstract::Multilocus sequence typing (MLST) is a recently developed nucleotide sequence-based method for the definitive assignment of isolates within bacterial populations to specific clones. MLST uses the same principles as multilocus enzyme electrophoresis and provides data that can be used to investigate aspects of the popul...

    journal_title:Molecular biology and evolution

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.molbev.a026061

    authors: Feil EJ,Maiden MC,Achtman M,Spratt BG

    更新日期:1999-11-01 00:00:00