Abstract:
:Previous studies have shown that genes that are expressed predominantly or exclusively in males tend to evolve rapidly in comparison to other genes. In most cases, however, it is unknown whether this rapid evolution is the result of increased positive (or sexual) selection on male-expressed traits or if it is due to a relaxation of selective constraints. To distinguish between these two possibilities, we analyzed the relationship between the nonsynonymous substitution rate (dN) and local recombination rate for 343 Drosophila genes that were classified as male, female, or nonsex biased in their expression. For the male-biased genes, a positive correlation between dN and recombination rate was observed. This can be explained by an increased rate of adaptive evolution in regions of higher recombination due to a reduction of Hill-Robertson interference. In contrast, the correlation between dN and recombination rate was negative for both female- and nonsex-biased genes, suggesting that these genes are primarily subject to purifying selection, which is expected to be less effective in regions of reduced recombination.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Zhang Z,Parsch Jdoi
10.1093/molbev/msi189subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1945-7issue
10eissn
0737-4038issn
1537-1719pii
msi189journal_volume
22pub_type
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