Evolution at the tip and base of the X chromosome in an African population of Drosophila melanogaster.

abstract：:Serum response factor (SRF) and myocyte enhancer factor 2 (MEF2) represent two types of members of the MCM1, AGAMOUS, DEFICIENS, and SRF (MADS)-box transcription factor family present in animals and fungi. Each type has distinct biological functions, which are reflected by the distinct specificities of the proteins bo...

journal_title：Molecular biology and evolution

authors： Wu W,Huang X,Cheng J,Li Z,de Folter S,Huang Z,Jiang X,Pang H,Tao S

更新日期：2011-01-01 00:00:00

abstract：:A recent genomewide screen identified 13 transposable elements that are likely to have been adaptive during or after the spread of Drosophila melanogaster out of Africa. One of these insertions, Bari-Juvenile hormone epoxy hydrolase (Bari-Jheh), was associated with the selective sweep of its flanking neutral variation...

journal_title：Molecular biology and evolution

authors： González J,Macpherson JM,Petrov DA

更新日期：2009-09-01 00:00:00

abstract：:The diploid D-genome lineage of the Triticum/Aegilops complex has an evolutionary history involving genomic contributions from ancient A- and B/S-genome species. We explored here the possible cytonuclear evolutionary responses to this history of hybridization. Phylogenetic analysis of chloroplast DNAs indicates that t...

journal_title：Molecular biology and evolution

authors： Li C,Sun X,Conover JL,Zhang Z,Wang J,Wang X,Deng X,Wang H,Liu B,Wendel JF,Gong L

更新日期：2019-02-01 00:00:00

abstract：:One of the most fundamental questions for understanding the origin of species is why genes that function to cause fertility in a pure-species genetic background fail to produce fertility in a hybrid genetic background. A related question is why the sex that is most often sterile or inviable in hybrids is the heterogam...

journal_title：Molecular biology and evolution

authors： Michalak P,Noor MA

更新日期：2003-07-01 00:00:00

abstract：:The diversity and evolution of bitter taste perception in mammals is not well understood. Recent discoveries of bitter taste receptor (T2R) genes provide an opportunity for a genetic approach to this question. We here report the identification of 10 and 30 putative T2R genes from the draft human and mouse genome seque...

journal_title：Molecular biology and evolution

authors： Shi P,Zhang J,Yang H,Zhang YP

更新日期：2003-05-01 00:00:00

abstract：:Most of the well-characterized mitochondrial genomes from diverse green algal lineages are circular mapping DNA molecules; however, Chlamydomonas reinhardtii has a linear 15.8 kb unit mitochondrial genome with 580 or 581 bp inverted repeat ends. In mitochondrial-enriched fractions prepared from Polytomella parva (=P. ...

journal_title：Molecular biology and evolution

authors： Fan J,Lee RW

更新日期：2002-07-01 00:00:00

abstract：:Examination of the genomic sequence of the telomere region makes it possible to understand the evolution of the structure of chromosomal ends. We compared the genomic sequences of 14 chromosomal ends of rice, Oryza sativa, L., on the basis of the variation in TTTAGGG repeats. In the proximal telomere repeats, nucleoti...

journal_title：Molecular biology and evolution

authors： Mizuno H,Wu J,Katayose Y,Kanamori H,Sasaki T,Matsumoto T

更新日期：2008-01-01 00:00:00

abstract：:Multiple haplotypes from each of three nuclear loci were isolated and sequenced from geographic populations of the American oyster, Crassostrea virginica. In tests of alternative phylogeographic hypotheses for this species, nuclear gene genealogies constructed for these haplotypes were compared to one another, to a mi...

journal_title：Molecular biology and evolution

authors： Hare MP,Avise JC

更新日期：1998-02-01 00:00:00

abstract：:During the adaptation of an organism to a parasitic lifestyle, various gene functions may be rendered superfluous due to the fact that the host may supply these needs. As a consequence, obligate symbiotic bacterial pathogens tend to undergo reductive genomic evolution through gene death (nonfunctionalization or pseudo...

journal_title：Molecular biology and evolution

authors： Dagan T,Blekhman R,Graur D

更新日期：2006-02-01 00:00:00

abstract：:The transposable element hobo has been introduced into the previously empty Drosophila melanogaster strain Hikone so that its dynamics can be followed and it can be compared with the P element. Five transformed lines were followed over 58 generations. The results were highly dependent on the culture temperature, the s...

journal_title：Molecular biology and evolution

authors： Galindo MI,Ladevèze V,Lemeunier F,Kalmes R,Periquet G,Pascual L

更新日期：1995-09-01 00:00:00

abstract：:Hepcidin is a small bioactive peptide with dual roles as an antimicrobial peptide and as the principal hormonal regulator of iron homeostasis in human and mouse. Hepcidin homologs of very similar structures are found in lower vertebrates, all comprise approximately 20-25 amino acids with 8 highly conserved cysteines f...

journal_title：Molecular biology and evolution

authors： Xu Q,Cheng CH,Hu P,Ye H,Chen Z,Cao L,Chen L,Shen Y,Chen L

更新日期：2008-06-01 00:00:00

abstract：:The chemokine receptor CCR5 can serve as a coreceptor for M-tropic HIV-1 infection and both M-tropic and T-tropic SIV infection. We sequenced the entire CCR5 gene from 10 nonhuman primates: Pongo pygmaeus, Hylobates leucogenys, Trachypithecus francoisi, Trachypithecus phayrei, Pygathrix nemaeus, Rhinopithecus roxellan...

journal_title：Molecular biology and evolution

authors： Zhang YW,Ryder OA,Zhang YP

更新日期：1999-09-01 00:00:00

abstract：:To investigate the potential importance of gene duplication in D. melanogaster accessory gland protein (Acp) gene evolution we carried out a computational analysis comparing annotated D. melanogaster Acp genes to the entire D. melanogaster genome. We found that two known Acp genes are actually members of small multige...

journal_title：Molecular biology and evolution

authors： Holloway AK,Begun DJ

更新日期：2004-09-01 00:00:00

abstract：:Most phylogenetic models assume that the evolutionary process is stationary and reversible. In addition to being biologically improbable, these assumptions also impair inference by generating models under which the likelihood does not depend on the position of the root. Consequently, the root of the tree cannot be inf...

journal_title：Molecular biology and evolution

authors： Cherlin S,Heaps SE,Nye TMW,Boys RJ,Williams TA,Embley TM

更新日期：2018-04-01 00:00:00

abstract：:Cysteine-rich secretory proteins (CRISPs) are glycoproteins found exclusively in vertebrates and have broad diversified functions. They are hypothesized to play important roles in mammalian reproduction and in reptilian venom, where they disrupt homeostasis of the prey through several mechanisms, including among other...

journal_title：Molecular biology and evolution

authors： Sunagar K,Johnson WE,O'Brien SJ,Vasconcelos V,Antunes A

更新日期：2012-07-01 00:00:00

abstract：:We examine rate heterogeneity among evolutionary lineages of the grass family at two plasmid loci, ndhF and rbcL, and we introduce a method to determine whether patterns of rate heterogeneity are correlated between loci. We show both that rates of synonymous evolution are heterogeneous among grass lineages and that ar...

journal_title：Molecular biology and evolution

authors： Gaut BS,Clark LG,Wendel JF,Muse SV

更新日期：1997-07-01 00:00:00

abstract：:With whole-genome sequences being completed at an increasing rate, it is important to develop and assess tools to analyze them. Following annotation of the protein content of a genome, one can compare sequences with previously characterized homologous genes to detect novel functions within specific proteins in the evo...

journal_title：Molecular biology and evolution

authors： Liberles DA

更新日期：2001-11-01 00:00:00

abstract：:During the last 60 years, the inversion polymorphism on the third chromosome of Drosophila pseudoobscura has become a case study of the evolution of linked blocks of genes, isolated from each other by the suppression of recombination in heterozygotes for different inversions. Due to its location within inverted region...

journal_title：Molecular biology and evolution

authors： Popadić A,Popadić D,Anderson WW

更新日期：1995-09-01 00:00:00

abstract：:At present there is tremendous interest in characterizing the magnitude and distribution of linkage disequilibrium (LD) throughout the human genome, which will provide the necessary foundation for genome-wide LD analyses and facilitate detailed evolutionary studies. To this end, a human high-density single-nucleotide ...

journal_title：Molecular biology and evolution

authors： Akey JM,Zhang K,Xiong M,Jin L

更新日期：2003-02-01 00:00:00

abstract：:Numerous studies have used indices of genetic distance between species to reconstruct evolutionary relationships and to estimate divergence time. However, the empirical relationship between molecular-based indices of genetic divergence and divergence time based on the fossil record is poorly known. To date, the result...

journal_title：Molecular biology and evolution

authors： Wayne RK,Van Valkenburgh B,O'Brien SJ

更新日期：1991-05-01 00:00:00

abstract：:An improved understanding of the biological and numerical properties of measures of population differentiation across loci is becoming increasingly more important because of their growing use in analyzing genome-wide polymorphism data for detecting population structures, inferring the rates of migration, and identifyi...

journal_title：Molecular biology and evolution

authors： Maruki T,Kumar S,Kim Y

更新日期：2012-12-01 00:00:00

abstract：:Focal copy number gains or losses are important genomic hallmarks of cancer. The genomic distribution of oncogenes and tumor-suppressor genes (TSG) in relation to focal copy number aberrations is unclear. Our analysis revealed that the mean distance of TSGs from oncogenes was significantly shorter than that of noncanc...

journal_title：Molecular biology and evolution

authors： Wu WK,Li X,Wang X,Dai RZ,Cheng AS,Wang MH,Kwong T,Chow TC,Yu J,Chan MT,Wong SH

更新日期：2017-04-01 00:00:00

abstract：:Selection on phenotypes may cause genetic change. To understand the relationship between phenotype and gene expression from an evolutionary viewpoint, it is important to study the concordance between gene expression and profiles of phenotypes. In this study, we use a novel method of clustering to identify genes whose ...

journal_title：Molecular biology and evolution

authors： Qu Y,Xu S

更新日期：2006-08-01 00:00:00

abstract：:Photosystem II, the water oxidizing enzyme, altered the course of evolution by filling the atmosphere with oxygen. Here, we reconstruct the origin and evolution of water oxidation at an unprecedented level of detail by studying the phylogeny of all D1 subunits, the main protein coordinating the water oxidizing cluster...

journal_title：Molecular biology and evolution

authors： Cardona T,Murray JW,Rutherford AW

更新日期：2015-05-01 00:00:00

abstract：:Animal microRNAs (miRNAs) are short RNAs that function as posttranscriptional regulators of gene expression by binding to the target mRNAs. Noting that some miRNAs are highly conserved in evolution, we explored the possibility of evolutionary conservation of their targets. We identified human orthologues of experiment...

journal_title：Molecular biology and evolution

authors： Lin YC,Hsieh LC,Kuo MW,Yu J,Kuo HH,Lo WL,Lin RJ,Yu AL,Li WH

更新日期：2007-11-01 00:00:00

abstract：:The marine cyanobacterium Prochlorococcus MED4 has the smallest sequenced genome of any photosynthetic organism. Prochlorococcus MED4 shares many genomic characteristics with chloroplasts and bacterial endosymbionts, including a reduced coding capacity, missing DNA repair genes, a minimal transcriptional regulatory ne...

journal_title：Molecular biology and evolution

authors： Hu J,Blanchard JL

更新日期：2009-01-01 00:00:00

abstract：:The complete nucleotide sequence of the mt (mitochondrial) and cp (chloroplast) genomes of the unicellular green alga Ostreococcus tauri has been determined. The mt genome assembles as a circle of 44,237 bp and contains 65 genes. With an overall average length of only 42 bp for the intergenic regions, this is the most...

journal_title：Molecular biology and evolution

authors： Robbens S,Derelle E,Ferraz C,Wuyts J,Moreau H,Van de Peer Y

更新日期：2007-04-01 00:00:00

abstract：:Light-dependent and dark-operative protochlorophyllide oxidoreductases (LPORs and DPORs) are evolutionary and structurally distinct enzymes that are essential for the synthesis of (bacterio)chlorophyll, the primary pigment needed for both anoxygenic and oxygenic photosynthesis. In contrast to the long-held hypothesis ...

journal_title：Molecular biology and evolution

authors： Chernomor O,Peters L,Schneidewind J,Loeschcke A,Knieps-Grünhagen E,Schmitz F,von Lieres E,Kutta RJ,Svensson V,Jaeger KE,Drepper T,von Haeseler A,Krauss U

更新日期：2020-09-15 00:00:00

abstract：:Computational tools with a balanced sensitivity and specificity in identification of candidate cancer drivers are highly desired. In this study, we propose a new statistical test, namely the dJ/dS ratio test, to compute the relative mutation rate of exon/intron junction sites (dJ) to synonymous sites (dS); observation...

journal_title：Molecular biology and evolution

authors： Chen H,Xing K,He X

更新日期：2015-08-01 00:00:00

abstract：:We measured nucleotide variability within and between the three semispecies of the Drosophila athabasca complex, at the period (per) gene by using a polymerase chain reaction-based four-cutter restriction-enzyme analysis. The levels of polymorphism varied considerably between the three semispecies. Our results for per...

journal_title：Molecular biology and evolution

authors： Ford MJ,Yoon CK,Aquadro CF

更新日期：1994-03-01 00:00:00