Phenotypic Plasticity Contributes to Maize Adaptation and Heterosis.

abstract：:Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 control. However, the actual mechanism of the observed heterozygote ad...

journal_title：Molecular biology and evolution

authors： Arora J,Pierini F,McLaren PJ,Carrington M,Fellay J,Lenz TL

更新日期：2020-03-01 00:00:00

abstract：:Proteins evolve not only through point mutations but also by insertion and deletion events, which affect the length of the protein. It is well known that such indel events most frequently occur in surface-exposed loops. However, detailed analysis of indel events in distantly related and fast-evolving proteins is hampe...

journal_title：Molecular biology and evolution

authors： Light S,Sagit R,Sachenkova O,Ekman D,Elofsson A

更新日期：2013-12-01 00:00:00

abstract：:Over time, natural selection molds every gene into a unique mosaic of sites evolving rapidly or resisting change-an "evolutionary fingerprint" of the gene. Aspects of this evolutionary fingerprint, such as the site-specific ratio of nonsynonymous to synonymous substitution rates (dN/dS), are commonly used to identify ...

journal_title：Molecular biology and evolution

authors： Pond SL,Scheffler K,Gravenor MB,Poon AF,Frost SD

更新日期：2010-03-01 00:00:00

abstract：:The high frequency of alternative splicing among the serine/arginine-rich (SR) family of proteins in plants has been linked to important roles in gene regulation during development and in response to environmental stress. In this article, we have searched and manually annotated all the SR proteins in the genomes of ma...

journal_title：Molecular biology and evolution

authors： Rauch HB,Patrick TL,Klusman KM,Battistuzzi FU,Mei W,Brendel VP,Lal SK

更新日期：2014-03-01 00:00:00

abstract：:The malaria parasite's chloroquine resistance transporter (CRT) is an integral membrane protein localized to the parasite's acidic digestive vacuole. The function of CRT is not known and the protein was originally described as a transporter simply because it possesses 10 transmembrane domains. In wild-type (chloroquin...

journal_title：Molecular biology and evolution

authors： Martin RE,Kirk K

更新日期：2004-10-01 00:00:00

abstract：:The level of DNA polymorphism in the ancestral species at the time of speciation can be estimated using DNA sequences from many loci sampled from 2 or more extant species. The comparison between ancestral and extant polymorphism can be informative about the population genetics of speciation. In this study, we collecte...

journal_title：Molecular biology and evolution

authors： Zhou R,Zeng K,Wu W,Chen X,Yang Z,Shi S,Wu CI

更新日期：2007-12-01 00:00:00

abstract：:The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with tho...

journal_title：Molecular biology and evolution

authors： Kovina AP,Petrova NV,Gushchanskaya ES,Dolgushin KV,Gerasimov ES,Galitsyna AA,Penin AA,Flyamer IM,Ioudinkova ES,Gavrilov AA,Vassetzky YS,Ulianov SV,Iarovaia OV,Razin SV

更新日期：2017-06-01 00:00:00

abstract：:In a series of highly influential publications, Cavalli-Sforza and colleagues used principal component (PC) analysis to produce maps depicting how human genetic diversity varies across geographic space. Within Europe, the first axis of variation (PC1) was interpreted as evidence for the demic diffusion model of agricu...

journal_title：Molecular biology and evolution

authors： François O,Currat M,Ray N,Han E,Excoffier L,Novembre J

更新日期：2010-06-01 00:00:00

abstract：:Liver and intestinal flukes of the family Fasciolidae cause zoonotic food-borne infections that impact both agriculture and human health throughout the world. Their evolutionary history and the genetic basis underlying their phenotypic and ecological diversity are not well understood. To close that knowledge gap, we c...

journal_title：Molecular biology and evolution

authors： Choi YJ,Fontenla S,Fischer PU,Le TH,Costábile A,Blair D,Brindley PJ,Tort JF,Cabada MM,Mitreva M

更新日期：2020-01-01 00:00:00

abstract：:Employing comparative analysis of the cDNA-coding sequences of the unique preprorelaxin of the Afro-lorisiform Galago crassicaudatus and the Malagasy lemur Varecia variegata and the relaxin-like factor (RLF) of G. crassicaudatus, we demonstrated distinct differences in the dynamics of molecular remodeling of both horm...

journal_title：Molecular biology and evolution

authors： Klonisch T,Froehlich C,Tetens F,Fischer B,Hombach-Klonisch S

更新日期：2001-03-01 00:00:00

abstract：:The plant pathogen Phytophthora infestans emerged in Europe in 1845, triggering the Irish potato famine and massive European potato crop losses that continued until effective fungicides were widely employed in the 20th century. Today the pathogen is ubiquitous, with more aggressive and virulent strains surfacing in re...

journal_title：Molecular biology and evolution

authors： Martin MD,Ho SY,Wales N,Ristaino JB,Gilbert MT

更新日期：2014-06-01 00:00:00

abstract：:Insertions and deletions (indels) in protein-coding genes are important sources of genetic variation. Their role in creating new proteins may be especially important after gene duplication. However, little is known about how indels affect the divergence of duplicate genes. We here study thousands of duplicate genes in...

journal_title：Molecular biology and evolution

authors： Guo B,Zou M,Wagner A

更新日期：2012-10-01 00:00:00

abstract：:MADS-box genes encode a family of transcription factors which control diverse developmental processes in flowering plants ranging from root development to flower and fruit development. Through phylogeny reconstructions, most of these genes can be subdivided into defined monophyletic gene clades whose members share sim...

journal_title：Molecular biology and evolution

authors： Becker A,Winter KU,Meyer B,Saedler H,Theissen G

更新日期：2000-10-01 00:00:00

abstract：:Dissecting the evolutionary genetic processes underlying eye reduction and vision loss in obligate cave-dwelling organisms has been a long-standing challenge in evolutionary biology. Independent vision loss events in related subterranean organisms can provide critical insight into these processes as well as into the n...

journal_title：Molecular biology and evolution

authors： Stern DB,Crandall KA

更新日期：2018-08-01 00:00:00

abstract：:Gene expression changes contribute to complex trait variations in both individuals and populations. However, the evolution of gene expression underlying complex traits over macroevolutionary timescales remains poorly understood. Snake venoms are proteinaceous cocktails where the expression of each toxin can be quantif...

journal_title：Molecular biology and evolution

authors： Barua A,Mikheyev AS

更新日期：2019-09-01 00:00:00

abstract：:Heterotachy occurs when the relative evolutionary rates among sites are not the same across lineages. Sequence alignments are likely to exhibit heterotachy with varying severity because the intensity of purifying selection and adaptive forces at a given amino acid or DNA sequence position is unlikely to be the same in...

journal_title：Molecular biology and evolution

authors： Gadagkar SR,Kumar S

更新日期：2005-11-01 00:00:00

abstract：:The most deviant isochore pattern within mammals was found in rat and mouse; most other mammals possess a different kind of isochore organization called the "general pattern." However, isochore patterns remain largely unknown in rodents other than mouse and rat. To investigate the taxonomic distribution of isochore pa...

journal_title：Molecular biology and evolution

authors： Robinson M,Gautier C,Mouchiroud D

更新日期：1997-08-01 00:00:00

abstract：:To test whether gaps resulting from sequence alignment contain phylogenetic signal concordant with those of base substitutions, we analyzed the occurrence of indel mutations upon a well-resolved, substitution-based tree for three nuclear genes in bumble bees (Bombus, Apidae: Bombini). The regions analyzed were exon an...

journal_title：Molecular biology and evolution

authors： Kawakita A,Sota T,Ascher JS,Ito M,Tanaka H,Kato M

更新日期：2003-01-01 00:00:00

abstract：:A major theoretical consequence of selection at a locus is the genetic hitchhiking of linked sites (selective sweep). The extent of hitchhiking around a gene is related to the strength of selection and the rate of recombination, with its impact diminishing with distance from the selected site. At the Rop-1 locus of th...

journal_title：Molecular biology and evolution

authors： Rose CJ,Chapman JR,Marshall SD,Lee SF,Batterham P,Ross HA,Newcomb RD

更新日期：2011-06-01 00:00:00

abstract：:Epigenetic information, which can be passed on independently of the DNA sequence, is stored in part in the form of histone posttranslational modifications and specific histone variants. Although complexes necessary for deposition have been identified for canonical and variant histones, information regarding the chroma...

journal_title：Molecular biology and evolution

authors： Ashraf K,Nabeel-Shah S,Garg J,Saettone A,Derynck J,Gingras AC,Lambert JP,Pearlman RE,Fillingham J

更新日期：2019-05-01 00:00:00

abstract：:Amino acids interact with each other, especially with neighboring amino acids, to generate protein structures. We studied the pattern of association and repulsion of amino acids based on 24,748 protein-coding genes from human, 11,321 from mouse, and 15,028 from Escherichia coli, and documented the pattern of neighbor ...

journal_title：Molecular biology and evolution

authors： Xia X,Xie Z

更新日期：2002-01-01 00:00:00

abstract：:Based on previous observations that newly inserted LINEs and SINEs have particularly long 3' A-tails, which shorten rapidly during evolutionary time, we have analyzed the rat and mouse genomes for evidence of recently inserted SINEs and LINEs. We find that the youngest predicted subfamilies of rodent identifier (ID) e...

journal_title：Molecular biology and evolution

authors： Odom GL,Robichaux JL,Deininger PL

更新日期：2004-11-01 00:00:00

abstract：:Taxonomic congruence and total evidence are competing paradigms in phylogenetic inference. Taxonomic congruence focuses on deriving a consensus from the results obtained from separately analyzed data sets, whereas total evidence uses character congruence in the search for the best-fitting hypothesis for all of the ava...

journal_title：Molecular biology and evolution

authors： Eernisse DJ,Kluge AG

更新日期：1993-11-01 00:00:00

abstract：:Bivalves have evolved a range of complex shell forming mechanisms that are reflected by their incredible diversity in shell mineralogy and microstructures. A suite of proteins exported to the shell matrix space plays a significant role in controlling these features, in addition to underpinning some of the physical pro...

journal_title：Molecular biology and evolution

authors： Arivalagan J,Yarra T,Marie B,Sleight VA,Duvernois-Berthet E,Clark MS,Marie A,Berland S

更新日期：2017-01-01 00:00:00

abstract：:Plants can show long-term effects of environmental stresses and in some cases a stress "memory" has been reported to persist across generations, potentially mediated by epigenetic mechanisms. However, few documented cases exist of transgenerational effects that persist for multiple generations and it remains unclear i...

journal_title：Molecular biology and evolution

authors： Morgado L,Preite V,Oplaat C,Anava S,Ferreira de Carvalho J,Rechavi O,Johannes F,Verhoeven KJF

更新日期：2017-08-01 00:00:00

abstract：:Analysis of mitochondrial DNA restriction fragment length polymorphism in European anchovy (Engraulis encrasicolus) revealed a large number of mitotypes that form two distinct clusters (phylads). Phylad A consists of one common mitotype and many rare secondary mitotypes that are one mutational step removed from the ma...

journal_title：Molecular biology and evolution

authors： Magoulas A,Tsimenides N,Zouros E

更新日期：1996-01-01 00:00:00

abstract：:DNA supercoiling is the master function that interconnects chromosome structure and global gene transcription. This function has recently been shown to be under strong selection in Escherichia coli. During the evolution of 12 initially identical populations propagated in a defined environment for 20,000 generations, p...

journal_title：Molecular biology and evolution

authors： Crozat E,Winkworth C,Gaffé J,Hallin PF,Riley MA,Lenski RE,Schneider D

更新日期：2010-09-01 00:00:00

abstract：:Coevolutionary conflict among imprinted genes that influence traits such as offspring growth may arise when maternal and paternal genomes have different evolutionary optima. This conflict is expected in outcrossing taxa with multiple paternity, but not self-fertilizing taxa. MEDEA (MEA) is an imprinted plant gene that...

journal_title：Molecular biology and evolution

authors： Miyake T,Takebayashi N,Wolf DE

更新日期：2009-04-01 00:00:00

abstract：:The genomics era has expanded our knowledge about the diversity of the living world, yet harnessing high-throughput sequencing data to investigate alternative evolutionary trajectories, such as hybridization, is still challenging. Here we present sppIDer, a pipeline for the characterization of interspecies hybrids and...

journal_title：Molecular biology and evolution

authors： Langdon QK,Peris D,Kyle B,Hittinger CT

更新日期：2018-11-01 00:00:00

abstract：:The authors of a recent manuscript in "Nature" claim to have discovered "universal trends" of amino acid gain and loss in protein evolution. Here, we show that this universal trend can be simply explained by a bias that is unavoidable with the 3-taxon trees used in the original analysis. We demonstrate that a rigorous...

journal_title：Molecular biology and evolution

authors： Goldstein RA,Pollock DD

更新日期：2006-07-01 00:00:00