Abstract:
:The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with those of other vertebrate species. In birds and mammals, the α- and β-globin genes are segregated into separate clusters located on different chromosomes and organized into chromatin domains of different types, whereas in cold-blooded vertebrates, including Danio rerio, α- and β-globin genes are organized into common clusters. The major globin gene locus of Danio rerio is of particular interest as it is located in a genomic area that is syntenic in vertebrates and is controlled by a conserved enhancer. We have found that the major globin gene locus of Danio rerio is structurally and functionally segregated into two spatially distinct subloci harboring either adult or embryo-larval globin genes. These subloci demonstrate different organization at the level of chromatin domains and different modes of spatial organization, which appears to be due to selective interaction of the upstream enhancer with the sublocus harboring globin genes of the adult type. These data are discussed in terms of evolution of linear and 3D organization of gene clusters in vertebrates.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Kovina AP,Petrova NV,Gushchanskaya ES,Dolgushin KV,Gerasimov ES,Galitsyna AA,Penin AA,Flyamer IM,Ioudinkova ES,Gavrilov AA,Vassetzky YS,Ulianov SV,Iarovaia OV,Razin SVdoi
10.1093/molbev/msx100subject
Has Abstractpub_date
2017-06-01 00:00:00pages
1492-1504issue
6eissn
0737-4038issn
1537-1719pii
3062800journal_volume
34pub_type
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