Abstract:
:We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In addition to well-known genes such as KIT, MC1R, ASIP, GHR, LCORL, NCAPG, WIF1, and ABCA12, we found evidence for a variety of novel and less-known genes under selection in cattle, such as LAP3, SAR1B, LRIG3, FGF5, and NUDCD3. Selective sweeps near LAP3 were then validated by next-generation sequencing. Genome-wide association analysis involving 26,362 Holsteins confirmed that LAP3 and SAR1B were related to milk production traits, suggesting that our candidate regions were likely functional. In addition, haplotype network analyses further revealed distinct selective pressures and evolution patterns across these five cattle breeds. Our results provided a glimpse into diverse genomic selection during cattle domestication, breed formation, and recent genetic improvement. These findings will facilitate genome-assisted breeding to improve animal production and health.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Xu L,Bickhart DM,Cole JB,Schroeder SG,Song J,Tassell CP,Sonstegard TS,Liu GEdoi
10.1093/molbev/msu333subject
Has Abstractpub_date
2015-03-01 00:00:00pages
711-25issue
3eissn
0737-4038issn
1537-1719pii
msu333journal_volume
32pub_type
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