Abstract:
:There are three common alleles (A, B, and O) at the human ABO blood group locus. We compared nucleotide sequences of these alleles, and relatively large numbers of nucleotide differences were found among them. These differences correspond to the divergence time of at least a few million years, which is unusually large for a human allelic divergence under neutral evolution. We constructed phylogenetic networks of human and nonhuman primate ABO alleles, and at least three independent appearances of B alleles from the ancestral A form were observed. These results suggest that some kind of balancing selection may have been operating at the ABO locus. We also constructed phylogenetic trees of ABO and their evolutionarily related alpha-1,3-galactosyltransferase genes, and the divergence time between these two families was estimated to be roughly 400 MYA.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Saitou N,Yamamoto Fdoi
10.1093/oxfordjournals.molbev.a025776subject
Has Abstractpub_date
1997-04-01 00:00:00pages
399-411issue
4eissn
0737-4038issn
1537-1719journal_volume
14pub_type
杂志文章abstract::With whole-genome sequences being completed at an increasing rate, it is important to develop and assess tools to analyze them. Following annotation of the protein content of a genome, one can compare sequences with previously characterized homologous genes to detect novel functions within specific proteins in the evo...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a003745
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journal_title:Molecular biology and evolution
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journal_title:Molecular biology and evolution
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doi:10.1093/oxfordjournals.molbev.a040111
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040199
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a025716
更新日期:1997-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040661
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/mss193
更新日期:2012-12-01 00:00:00
abstract::The geographic origin and time of dispersal of Austroasiatic (AA) speakers, presently settled in south and southeast Asia, remains disputed. Two rival hypotheses, both assuming a demic component to the language dispersal, have been proposed. The first of these places the origin of Austroasiatic speakers in southeast A...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/molbev/msq288
更新日期:2011-02-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a003958
更新日期:2001-09-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Molecular biology and evolution
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journal_title:Molecular biology and evolution
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journal_title:Molecular biology and evolution
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Molecular biology and evolution
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00