Abstract:
:Several authors reported lower frequencies of protein sequence convergence between more distantly related evolutionary lineages and attributed this trend to epistasis, which renders the acceptable amino acids at a site more different and convergence less likely in more divergent lineages. A recent primate study, however, suggested that this trend is at least partially and potentially entirely an artifact of gene tree discordance (GTD). Here, we demonstrate in a genome-wide data set from 17 mammals that the temporal trend remains (1) upon the control of the GTD level, (2) in genes whose genealogies are concordant with the species tree, and (3) for convergent changes, which are extremely unlikely to be caused by GTD. Similar results are observed in a comparable data set of 12 fruit flies in some but not all of these tests. We conclude that, at least in some cases, the temporal decline of convergence is genuine, reflecting an impact of epistasis on protein evolution.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Zou Z,Zhang Jdoi
10.1093/molbev/msx109subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1682-1688issue
7eissn
0737-4038issn
1537-1719pii
3098657journal_volume
34pub_type
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