Abstract:
:It has recently been observed by Ho et al. (Ho SYW, Phillips MJ, Cooper A, Drummond AJ. 2005. Time dependency of molecular rate estimates and systematic overestimation of recent divergence times. Mol Biol Evol. 22(7):1561-1568) that apparent rates of molecular evolution increase when measured over short timespans. I investigate whether the data are explainable purely by deleterious mutations. I derive an empirical approximation for the persistence of these mutations in a randomly mating population and, hence, derive lower limits on effective population sizes. These limits are high and get higher if additional reasonable assumptions are made. This casts doubt on whether deleterious mutations are able to explain the apparent rate acceleration.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Woodhams Mdoi
10.1093/molbev/msl107subject
Has Abstractpub_date
2006-12-01 00:00:00pages
2271-3issue
12eissn
0737-4038issn
1537-1719pii
msl107journal_volume
23pub_type
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pub_type: 历史文章,信件
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pub_type: 杂志文章
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pub_type: 杂志文章
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