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Rapid R2 retrotransposition leads to the loss of previously inserted copies via large deletions of the rDNA locus.

Abstract：

:R2 non-long terminal repeat retrotransposable elements insert specifically into the 28S rRNA genes of a wide range of animals. These elements maintain long-term stable relationships with the host genome. By scoring the variation present at the 5' ends of individual R2 copies, lines of Drosophila simulans have been identified with high rates of R2 retrotransposition. Comparing the R2 elements present in the parents with that of their progeny after 1 or 30 generations in this report revealed that retrotransposition rates were higher through the female germ line compared with the male germ line. In addition, most events in females occur late in germ line development. Surprisingly, the gain of new R2 insertions by retrotranspositions was counterbalanced by deletions of preexisting R2 insertions. These deletions occurred by the loss of large segments of the rDNA units that contained on average an estimated 15 R2 elements. When monitored over single generations, the rate of loss of preexisting elements was higher than the rate of new insertions. However, the chromosomes with the largest deletions appear to be eliminated from the population because the rates of R2 insertions and deletions after 30 generations were approximately equal. These findings suggest that high rates of R2 retrotransposition do not necessarily lead to dramatic increases in the level of R2 insertions in the rDNA locus but can lead to a more rapid turnover of rDNA units.

journal_name

Mol Biol Evol

journal_title

Molecular biology and evolution

authors

Zhang X,Zhou J,Eickbush TH

doi

10.1093/molbev/msm250

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

229-37

issue

1

eissn

0737-4038

issn

1537-1719

pii

msm250

journal_volume

25

pub_type

杂志文章

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