Abstract:
:Alu is a predominant short interspersed element (SINE) family in the human genome and consists of two monomer units connected by an A-rich linker. At present, dimeric Alu elements are active in humans, but Alu monomers are present as fossilized sequences. A comparative genome analysis of human and chimpanzee genomes revealed eight recent insertions of Alu monomers. One of them was a retroposed product of another Alu monomer with 3' transduction. Further analysis of 1,404 loci of the Alu monomer in the human genome revealed that some Alu monomers were recently generated by recombination between the internal and 3' A-rich tracts inside of dimeric Alu elements. The data show that Alu monomers were generated by 1) retroposition of other Alu monomers and 2) recombination between two A-rich tracts.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Kojima KKdoi
10.1093/molbev/msq218subject
Has Abstractpub_date
2011-01-01 00:00:00pages
13-5issue
1eissn
0737-4038issn
1537-1719pii
msq218journal_volume
28pub_type
信件abstract::Cytochrome c oxidase (COX) consists of 13 subunits, 3 encoded in the mitochondrial genome and 10 in the nucleus. Little is known of the role of the nuclear-encoded subunits, some of which exhibit tissue-specific isoforms. Subunit VIa is unique in having tissue-specific isoforms in all mammalian species examined. We ex...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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