Abstract:
:In the age of whole-genome population genetics, so-called genomic scan studies often conclude with a long list of putatively selected loci. These lists are then further scrutinized to annotate these regions by gene function, corresponding biological processes, expression levels, or gene networks. Such annotations are often used to assess and/or verify the validity of the genome scan and the statistical methods that have been used to perform the analyses. Furthermore, these results are frequently considered to validate "true-positives" if the identified regions make biological sense a posteriori. Here, we show that this approach can be potentially misleading. By simulating neutral evolutionary histories, we demonstrate that it is possible not only to obtain an extremely high false-positive rate but also to make biological sense out of the false-positives and construct a sensible biological narrative. Results are compared with a recent polymorphism data set from Drosophila melanogaster.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Pavlidis P,Jensen JD,Stephan W,Stamatakis Adoi
10.1093/molbev/mss136subject
Has Abstractpub_date
2012-10-01 00:00:00pages
3237-48issue
10eissn
0737-4038issn
1537-1719pii
mss136journal_volume
29pub_type
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