Abstract:
:There is increasing evidence that X chromosomes have an unusual complement of genes, especially genes that have sex-specific expression. However, whereas in worm and fly the X chromosome has a dearth of male-specific genes, in mice genes that are uniquely expressed in spermatogonia are especially abundant on the X chromosome. Is this latter enrichment true for nongermline, male-specific genes in mammals, and is it found also for female-specific genes? Here, using SAGE data, we show (1) that tissue-specific genes tend to be more abundant on the human X chromosome, (2) that, controlling for this effect, genes expressed exclusively in prostate are enriched on the human X chromosome, and (3) that genes expressed exclusively in mammary gland and ovary are not so enriched. This we propose is consistent with Rice's model of the evolution of sexually antagonistic alleles.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Lercher MJ,Urrutia AO,Hurst LDdoi
10.1093/molbev/msg131subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1113-6issue
7eissn
0737-4038issn
1537-1719pii
msg131journal_volume
20pub_type
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