Abstract:
:A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserved exon-intron pattern and (2) family-specific combinations of amino acid residues at specific sites suggests that present-day vertebrates encompass six serpin gene families which evolved from primordial genes by massive intron insertion before or during early vertebrate radiation. Introns placed at homologous positions in the gene sequences in combination with diagnostic sequence characters may also constitute a reliable kinship indicator for other protein superfamilies.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Ragg H,Lokot T,Kamp PB,Atchley WR,Dress Adoi
10.1093/oxfordjournals.molbev.a003838subject
Has Abstractpub_date
2001-04-01 00:00:00pages
577-84issue
4eissn
0737-4038issn
1537-1719journal_volume
18pub_type
杂志文章abstract::We describe a stochastic birth-and-death model of evolution of horizontally transferred genes in microbial populations. The model is a generalization of the stochastic model described by Berg and Kurland and includes five parameters: the rate of mutational inactivation, selection coefficient, invasion rate (i.e., rate...
journal_title:Molecular biology and evolution
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a040360
更新日期:1985-09-01 00:00:00
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journal_title:Molecular biology and evolution
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pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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journal_title:Molecular biology and evolution
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更新日期:2012-11-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Molecular biology and evolution
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00