Abstract:
:Conduction speed (theta) in single myelinated Rana pipiens sciatic nerve fibers has been precisely measured using intracellular recording and on-line digital computer techniques. The dependence of relative speed on external Na concentration at 15 degrees C has been found to be ln(theta(1)/theta(2)) = 0.524 (+/-0.018) ln ([Na(+)](1)/[Na(+)](2)) + 0.003. Thus theta has very close to a square root dependence on [Na(+)](0) for these fibers. This experimental finding is not in complete agreement with a theoretical prediction based on a solution of the Hodgkin-Huxley (H.H.) equations. The effect of small temperature variations around 15 degrees C on theta has also been measured for Rana fibers in Ringer's solution. theta has close to an exponential dependence on T and a Q(10) of 2.95 has been estimated.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Hardy WLdoi
10.1016/S0006-3495(73)86045-Xsubject
Has Abstractpub_date
1973-10-01 00:00:00pages
1054-70issue
10eissn
0006-3495issn
1542-0086pii
S0006-3495(73)86045-Xjournal_volume
13pub_type
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